Prof. Jacques
Thibodeau
Université
de Montréal, Canada
E-mail:
Jacques.thibodeau@umontreal.ca
Qualifications
1986-1991
Ph.D. (biologie moléculaire), Université Laval, Québec (Québec), Canada
1982-1985
M.Sc. (microbiology), Université de Sherbrooke, Sherbrooke (Québec), Canada
1979-1982
B.Sc. (biology), Université Laval, Québec (Québec), Canada
Publications
(Selected)
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Denis,
F., Shoukry, N., Delcourt, M., Thibodeau, J., Labrecque, N., Mcgrath, H.,
Munzer, S., Seidah, N.G., and Sékaly, R.P. (2000) Alternative Proteolytic
Processing of Mouse Mammary Tumor Virus Superantigens. J. Virol., 74: 3067-3073.
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Brunet,
A., Samaan, A., Deshaies, F., Kindt, T.J. and Thibodeau, J. (2000) Functional
Characterization of a Di-leucine Lysosomal Sorting Motifs in the Cytoplasmic
Tail of HLA-DOb. J. Biol. Chem., 275: 37062-37071.
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Lavoie,
P.M., Mcgrath, H., Shoukry, N.H., Cazenave, P.A., Sékaly, R.P. and Thibodeau,
J. (2001) Quantitative relationship between MHC class II/superantigen complexes
and the balance of T cell activation versus death. J.Immunol., 166: 7229-7237.
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Faubert,
A., Samaan, A. and Thibodeau, J. (2002) Functional Analysis of Tryptophans a62
and b120 on HLA-DM. J. Biol. Chem., 277: 2750-2755.
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Azar,
G. and Thibodeau, J. (2002) Human Endogenous Retrovirus IDDMK1,222 and Mouse
Mammary Tumor Virus Superantigens Differ in Their Ability to Stimulate Murine T
Cell Hybridomas. Immunol. Letters, 81: 87-91.
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Khalil,
H., Deshaies, F., Bellemare-Pelletier, A., Brunet, A., Faubert, A., Azar, G.
and Thibodeau, J. (2002) CIITA-induced expression of HLA-DOb in HeLa cells.
Tissue Antigens 60: 372-382.
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Lapointe,
R., Bellemare-Pelletier, A., Housseau, F., Thibodeau, J. and Hwu, P. (2003)
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen
presenting cells and can generate specific T cells. Cancer Research,
63: 2836-2843.
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Bouillon,
M., El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W. (2003) Lipid
Raft-dependent and -independent signaling through HLA-DR molecules. J. Biol.
Chem. 278: 7099-7107.
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Khalil,
H., Brunet, A., Saba, I., Terra, R., Sékaly, R.P. and Thibodeau, J. (2003) The
MHC class II b chain cytoplasmic tail overcomes the invariant chain p35-encoded
endoplasmic reticulum retention signal. Int. Immunol., 15: 1249-1263.
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El
Fakhry, Y., Bouillon, M., Léveillé, C., Brunet, A., Khalil, H., Thibodeau, J.,
and Mourad, W. (2004) Delineation of the HLA-DR region and the residues involved
in the association with the cytoskeleton. J. Biol. Chem., 279: 18472-80.
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Lapointe,
R., Thibodeau, J. and Hwu, P. (2004) Correspondence re R. Lapointe et al.,
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective
antigen-presenting cells that can generate specific T cells. Cancer Res. 64:
4056-4057.
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Martin,
G., Beauséjour, Y., Thibodeau, J. and Tremblay, M.J. (2005) Envelope
glycoproteins are dispensable for insertion of host HLA-DR molecules within
nascent human immunodeficiency virus type 1 virions. Virology, 335: 286-290.
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Bellemare-Pelletier,
A., Tremblay, J., Beaulieu, S., Boulassel, R., Routhy, J.P., Massie, B.,
Lapointe, R. and Thibodeau, J. (2005) HLA-DO transduced in human
monocyte-derived dendritic cells modulates antigen presentation.J. Leuk. Biol.,
78: 95-105.
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Azar,
G., Sékaly, R.P. and Thibodeau, J. (2005) A defective viral
superantigen-presenting phenotype in HLA-DR transfectants is corrected by
CIITA. J. Immunol. 174: 7548-7557.
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Deshaies,
F., Brunet, A., Diallo, D., Denzin, L., Samaan, A. and Thibodeau, J. (2005) A
point mutation in the groove of HLA-DO allows egress from the endoplasmic
reticulum independent of HLA-DM. Proc. Natl. Acad. Sci. USA 102: 6443-6448.
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Khalil,
H, Brunet, A. and Thibodeau, J. (2005) A three amino acid-long DRb cytoplasmic
tail is sufficient to overcome ER retention of Iip35. J. Cell Sci.
118:4679-4687. Funded by Boehringer Ingelheim and Diabète Québec.
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Deshaies
F. et Thibodeau J. (2005) HLA-DO: Régulateur de la Réponse Immunitaire.
Médecine/Sciences. 21: 11-13.
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Clément,
M., Tremblay, J., Lange, M., Thibodeau, J. and Belhumeur, P. (2006) Whey
derived free fatty acids suppress germination of Candida albicans in vitro.
FEMS Yeast Research. 7: 276-285. Funded by Saputo.
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Finzi,
A., Brunet, A., Xiao, Y., Thibodeau, J. and Cohen, E.A. (2006) Major
Histocompatibility Complex class II molecules promote human immunodeficiency
virus type I assembly and budding to late endosomal/multivesicular body
compartments. J. Virol. 80:9789-9797. Funded by the CIHR and FRSQ.
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De
Gassart, A., Camossetto, A., Thibodeau, J., Ceppi, M., Catalan, N., Pierre, P.
and Gatti, E. (2008) MHC class II stabilization at the surface of human
dendritic cells is the result of maturation-dependent MARCH I downregulation.
Proc. Natl. Acad. Sci. USA 105: 3491-3496 Funded by the CIHR.