Prof. Alexander A. Konstantinov
Moscow State University, Russia
Email: konst@genebee.msu.su
Qualifications
1985 Ph.D., Biochemistry, Moscow State University
1972 M.Sc., Biochemistry, Moscow State University
Publications (selected)
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Vos, M.H., Borisov,V.B., Liebl,U., Martin,J.L., Konstantinov,A.A. (2000) Femtosecond resolution of ligand-heme interactions in the high-affinity quinol oxidase bd: a di-heme active site? Proc. Natl. Acad. Sci. USA 97, 1554-1559.
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Jasaitis, A., Borisov, V. B., Belevich, N. P., Morgan, J. E., Konstantinov, A. A., and Verkhovsky, M. I. (2000) Electrogenic reactions of cytochrome bd. Biochemistry. 39:13800-13809.
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Dzhagarov. B.M., Belyanovich, L.M., Konstantinov,A.A., Rudenok,A.A. and Tikhomirov, S.A. (2000) Picosecond absorption spectroscopy of cytochrome c oxidase: excited states and relaxation processes in the heme groups of cytochromes a and a3. Dokl. Akad. Nauk 375, 112-114
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Borisov, V. N., Selednikova, S. E., Poole, R. E., and Konstantinov, A. A. (2001) Interaction of cytochrome bd with carbon monoxide at low and room temperatures. J.Biol.Chem. 276, 22095-22099
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Pecoraro, C., Gennis R. B., Vygodina, T. V., and Konstantinov, A. A. (2001) Role of the K-channel in the pH-dependence of the Reaction of Cytochrome c Oxidase with Hydrogen Peroxide. Biochemistry 40, 9695-9708
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Zhang, J., Hellwig, P., Osborne, J. P., Huang, H.-w., Moenne-Loccoz, P., Konstantinov, A. A., and Gennis, R. B. (2001) Site-directed mutations of the highly conserved region near the Q-loop of the cytochrome bd quinol oxidase from Escherichia coli specifically perturbs heme b595. Biochemistry 40, 8548-8556
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Borisov,V.B., Liebl,U., Rappaport,F., Martin, J.-L., Zhang,J., Gennis, R., Konstantinov, A.A. and Vos, M. (2002) Interactions between Heme d and Heme b595 in Quinol Oxidase bd from Escherichia coli: A Photoselection Study Using Femtosecond Spectroscopy. Biochemistry 41, 1654-1662
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Azarkina, N, Konstantinov, A.A. (2002) Stimulation of menaquinone-dependent electron transfer in the respiratory chain of Bacillus subtilis by membrane energization. Journal Bacteriology 184, 5339-47.
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Lee, A, Kirichenko, A, Vygodina, T, Siletsky, S.A, Das, T.K, Rousseau, D.L, Gennis, R, Konstantinov AA. (2002) Ca(2+)-binding site in Rhodobacter sphaeroides cytochrome C oxidase. Biochemistry 41, 8886-98.
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Pereverzev, M.O, Vygodina, T.V, Konstantinov, A.A, Skulachev, V.P. (2003) Cytochrome c, an ideal antioxidant. Biochem. Soc. Transac. 31, 1312-5. Review.
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Borisov, V.B, Forte, E, Konstantinov, A.A, Poole, R.K, Sarti, P, Giuffrè, A. (2004) Interaction of the bacterial terminal oxidase cytochrome bd with nitric oxide. FEBS Lett. 576, 201-4.
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Siletsky, S.A, Pawate, A.S, Weiss, K, Gennis, R.B, Konstantinov, A.A. (2004) Transmembrane charge separation during the ferryl-oxo -> oxidized transition in a nonpumping mutant of cytochrome c oxidase. J. Biol. Chem. 279, 52558-65.
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Kirichenko, A.V, Pfitzner, U, Ludwig, B, Soares, C.M, Vygodina, T.V, Konstantinov, A.A. (2005) Cytochrome c oxidase as a calcium binding protein. Studies on the role of a conserved aspartate in helices XI-XII cytoplasmic loop in cation binding. Biochemistry. 44, 12391-401.
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Belevich I, Borisov VB, Konstantinov AA, Verkhovsky MI. (2005) Oxygenated complex of cytochrome bd from Escherichia coli: stability and photolability. FEBS Lett. 579,4567-70.
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Kuznetsova, S.S, Azarkina, N.V, Vygodina, T.V, Siletsky, S.A, Konstantinov, A.A. (2005) Zinc ions as cytochrome C oxidase inhibitors: two sites of action. Biochemistry (Mosc). 70, 128-36.
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Fernandes, A.S, Konstantinov, A.A, Teixeira, M, Pereira, M.M. (2005) Quinone reduction by Rhodothermus marinus succinate:menaquinone oxidoreductase is not stimulated by the membrane potential. Biochem. Biophys. Res. Commun. 330, 565-70.
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Belevich, I, Borisov, V.B, Zhang, J, Yang, K, Konstantinov, A.A, Gennis, R.B, Verkhovsky, M.I. (2005) Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site. Proc. Natl Acad Sci. U S A 102, 3657-62.
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Siletsky, S.A, Han, D, Brand, S, Morgan, J.E, Fabian, M, Geren, L, Millett, F, Durham, B, Konstantinov, A.A, Gennis, R.B. (2006) Single-electron photoreduction of the P(M) intermediate of cytochrome c oxidase. Biochimica Biophysica Acta. 1757,1122-32.
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Borisov, V.B, Forte, E, Sarti, P, Brunori, M, Konstantinov, A.A, Giuffrè, A. (2006) Nitric oxide reacts with the ferryl-oxo catalytic intermediate of the CuB-lacking cytochrome bd terminal oxidase. FEBS Lett. 580, 4823-6.
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Vygodina TV, Konstantinov AA. (2007) Peroxidase activity of mitochondrial cytochrome с oxidase. Biochemistry (Mosc) 72, 1056-64.
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Siletsky, S.A, Belevich, I, Jasaitis, A, Konstantinov, A.A, Wikström, M, Soulimane, T, Verkhovsky, M.I. (2007) Time-resolved single-turnover of ba(3) oxidase from Thermus thermophilus. Biochim. Biophys. Acta 1767, 1383-92.
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Belevich, I, Borisov, V.B, Bloch, D.A, Konstantinov, A.A, Verkhovsky, M.I. (2007) Cytochrome bd from Azotobacter vinelandii: evidence for high-affinity oxygen binding. Biochemistry 46, 11177-84.
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Borisov, V.B, Forte, E, Sarti, P, Brunori, M, Konstantinov, A.A, Giuffrè, A.(2007) Redox control of fast ligand dissociation from Escherichia coli cytochrome bd. Biochem. Biophys. Res. Commun. 355, 97-102.
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Forte, E., Borisov, V.B., Konstantinov, A.A., Brunori, M., Giuffrè, A., Sarti, P. (2007) Cytochrome bd, a key oxidase in bacterial survival and tolerance to nitrosative stress.Ital J Biochem.56, 265-269.
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Arutyunyan. A.M, Borisov, V.B., Novoderezhkin, V.I., Ghaim, J., Zhang, J., Gennis, R.B., Konstantinov, A.A. (2008) Strong excitonic interactions in the oxygen-reducing site of bd-type oxidase: the Fe-to-Fe distance between hemes d and b595 is 10 A. Biochemistry 47, 1752-1759
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Yang, K., Borisov, V.B., Konstantinov, A.A., Gennis, R.B. (2008) The fully oxidized form of the cytochrome bd quinol oxidase from E. coli does not participate in the catalytic cycle: direct evidence from rapid kinetics studies.FEBS Lett. 582, 3705-3709
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