Dr. Feng
Cheng
Department of
Pharmaceutical Sciences, College of Pharmacy
University of South Florida, USA
Assistant
professor
Email: fcheng1@health.usf.edu
Qualifications
2010
Ph.D., University of Virginia, Biophysics
2003
Ph.D., Chinese Academy of Science, Medicinal Chemistry
1998
B.Sc., Nanjing University, Chemistry
Publications(Selected)
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Spatiotemporal
transcriptome of the human brain. Hyo Jung Kang*, Yuka Imamura Kawasawa*, Feng
Cheng*, Ying Zhu*, Xuming Xu, Mingfeng Li*, André M. M. Sousa, Mihovil
Pletikos, Kyle A. Meyer, Goran Sedmak, Tobias Guennel, Yurae Shin, Matthew B.
Johnson, Željka Krsnik, Simone Mayer, Sofia Fertuzinhos, Sheila Umlauf, Steven
N. Lisgo, Alexander Vortmeyer, Daniel R. Weinberger, Shrikant Mane, Thomas M.
Hyde, Anita Huttner, Mark Reimers, Joel E. Kleinman and Nenad Šestan. Nature
2011 478, 483–489 * Equal Contribution.
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In vitro
transcriptomic prediction of hepatotoxicity for large drug screening. Feng
Cheng, Dan Theodorescu Ira G. Schulman, and Jae K. Lee. Journal of Theoretical
Biology 2011, 290C, 27-36.
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Multi-gene
molecular signatures for predicting the risk of atherosclerosis. Feng Cheng,
Ellen C. Keeley, Klaus Ley, and Jae K. Lee. BMC Medical Genomics 2012 5:2.
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Multivariate
molecular expression-based predictions of clinical outcome. Feng Cheng, Sang-Hoon
Cho, and Jae K. Lee. “Statistical Methods in Molecular Biology”. Human
Press, 2010.
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Interaction
Models of a Series of Oxadiazole-Substituted alpha-Isopropoxy Phenylpropanoic
Acids Against PPAR alpha and PPAR gamma. Feng Cheng, Jianhua Shen, Xiaoying Xu,
Xiaomin Luo, Kaixian Chen, Xu Shen and Hualiang Jiang. Protein and Peptide
Letters 2009, 16, 150-162.
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Molecular
Docking Studies on the Interactions between the Thioesterase Domain of Human
Fatty Acid Synthase and Its Ligands. Feng Cheng, Qinghua Wang, Florante A.
Quiocho and Jianpeng Ma. PROTEINS: Structure, Function, and Bioinformatics
2008, 1228-1234.
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A Solid State
13C NMR, Crystallographic and Quantum Chemical Investigation of Chemical Shifts
and Hydrogen Bonding in Histidine Dipeptides. Feng Cheng, Haihong Sun Yong
Zhang, Dushyant Mukkamala and Eric Oldfield. J. Am. Chem. Soc. 2005, 127(36):
12544-12554.
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Inhibition of
Isoprene Biosynthesis Pathway Enzymes by Phosphonates, Bisphosphonates, and
Diphosphates. Feng Cheng and Eric Oldfield. J. Med. Chem. 2004, 47: 5149-5158.
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Quantum
Chemistry Study on the Interaction of the Exogenous Ligands and the Catalytic
Zinc Ion in Matrix Metalloproteinases. Feng Cheng, Xiaomin Luo, Jianhua Shen,
Xin Li, Jiande Gu, Weiliang Zhu, Ruihao Zhang, Jingkang Shen, Irit Sagi, Ruyun
Ji, Kaixian Chen and Hualiang Jiang. J. Phys. Chem. B, 2002, 106: 4552-4559.
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Steered
Molecular Dynamics Simulations on the Tail Helix Latch Hypothesis in the
Gelsolin Activation Process. Feng Cheng, Jianhua Shen, Xiaomin Luo, Hualiang
Jiang and Kaixian Chen. Biophys. J. 2002, 83: 753-762.
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Molecular
Docking and 3D-QSAR Studies on the Possible Antimalarial Mechanism of
Artemisinin Analogues. Feng Cheng, Jianhua Shen, Xiaomin Luo, Weiliang Zhu,
Jiande Gu, Ruyun Ji, Hualiang Jiang and Kaixian Chen. Bioorg. & Med. Chem.
2002, 10: 2883-2891.
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The progress
in the design of Matrix metalloproteinase. Feng Cheng, Hong Liu, Hualiang
Jiang, Kaixian Chen and Ruyun Ji. Progress in Chemistry (Chinese), 2001, 13(4):
283-293.
-
The research
progress of PPAR agonists. Feng Cheng, Jianhua Shen, Xiaomin Luo, Jingkang
Shen, Hualiang Jiang and Kaixian Chen. Chin. Med. Chem.(Chinese) 2003, 13:
110-120.
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Crystal Structure of
Unliganded Influenza B Virus Hemagglutinin. Qinghua Wang, Feng Cheng, Mingyang
Lu, Xia Tian, and Jianpeng Ma. Journal of Virology 2008, 82: 3011–3020.
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Agonist-PPAR
Interactions: A Molecular Modeling Study with Docking Approach. Xiaoying Xu,
Feng Cheng, Jianhua Shen, Xiaomin Luo, Lili Chen, Liduo Yue, Yi Du, Fei Ye,
Shanhao Jiang, Dayuan Zhu, Hualiang Jiang and Kaixian Chen. Int. J. Quantum
Chem. 2003, 93: 405-410.
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Binding
Mechanism of H5N1 Influenza Virus Neuraminidase with Ligands and its
Implication for Drug Design. K. Gong, L. Li, J.-F. Wang, F. Cheng, D.-Q. Wei
and K.-C. Chou. Medicinal Chemistry 2009, 5, 242-249
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Concordant
gene expression signatures predict clinical outcomes of cancer patients
undergoing chemotherapy. Paul D. Williams, Sooyoung Cheon, Dmytro M.
Havaleshko, Hyeon Jeong, Feng Cheng, Dan Theodorescu and Jae K. Lee. Cancer
Research 2009, 69 (21), 8302-8309.
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Virtual
Screening on Natural Products for Discovering Active Compounds and Target
Information. Jianhua Shen, Xiaoying Xu, Feng Cheng, Hong Liu, Xiaomin Luo,
Jingkang Shen, Kaixian Chen, Weimin Zhao, Xu Shen and Hualiang Jiang. Curr.
Med. Chem. 2003, 10, 1241-1253.
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Structure-Based
3-D-QSAR Analysis of Marine Indole Alkaloids. Biao Jiang, Wen-Nan Xiong,
Cai-Guang Yang, Hua-Liang Jiang, Feng Cheng, Kai-Xian Chen. Bioorg. Med. Chem.
2002, Aug;10(8):2775-8.
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Binding
analyses between Human PPARgamma-LBD and ligands. Changying Yu, Lili Chen,
Haibing Luo, Jing Chen, Feng Cheng, Chunshan Gui, Ruihao Zhang, Jianhua Shen,
Kaixian Chen, Hualiang Jiang and Xu Shen. Eur J Biochem, 2004, 271: 386-397.
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Structure-Based
Discovery of Potassium Channel Blockers from Natural Products: Virtual
Screening and Electrophysiological Assay Testing. Hong Liu, Yang Li, Mingke
Song, Xiaojian Tan, Feng Cheng, Suxin Zheng, Jianhua Shen, Xiaomin Luo, Ruyun
Ji, Jianmin Yue, Guoyuan Hu, Hualiang Jiang, and Kaixian Chen. Chemistry &
Biology, 2003, 10,1103-1113.
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Differentiation
of Cation-pi Bonding from Cation-pi Interactions: A Quantum Chemistry Study
Using Density-Functional Theory and Morokuma Decomposition Methods. Weiliang
Zhu, Xiaojian Tan, Jianhua Shen, Xiaomin Luo, Feng Cheng, Puah Chum Mok, Ruyun
Ji, Kaixian Chen, Hualiang Jiang. J. Phys. Chem. A, 2003, 13: 2296-2303.
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Steered
Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT.
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Lingling Shen,
Jianhua Shen, Xiaomin Luo, Feng Cheng, Yechun Xu, Kaixian Chen, Edward Arnold,
Jianping Ding, and Hualiang Jiang. Biophysical Journal, 2003, 84:3547-3563.
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Structure
Feature of AChE Inhibitor Huperzine B in Nature and in the Binding Site of
AChE: Density Functional Theory Study Combined with IR Determination. Xiaomin
Luo, Feng Cheng, Xiaojian Tan, Dayuan Zhu, Kaixian Chen, Hualiang Jiang et al.
J. Theo. Comput. Chem. 2002, 1: 81-92.
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Structural
Characterization of the Catalytic Active Site in the Latent and Active Natural
Gelatinase B from Human Neutrophils. Oded Kleifeld, Philippe E. Van den Steen,
Anatoly Frenkeli, Feng Cheng, Hualiang Jiang, Ghislain Opdenakker, and Irit
Sagi. J. Biol. Chem. 2000, 275: 34335-34343.
Profile
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Last Updated:
August 2, 2012.
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