Prof. Wan Lee

Dongguk University School of Medicine, Korea

Email: wanlee21@yahoo.com

Qualifications

1998 Ph.D., Seoul National University, Biochemistry and Biophysics

1988 M.Sc., Seoul National University, Physiology

1986 D.V.M., Seoul National University, Veterinary Medicine

Publications (Selected)

1. Won-Mo Yang, Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells. FEBS Lett. 588(21):3939-3946.
2. Won-Mo Yang, Wan Lee (2014) CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochem Biophys Res Commun. 452(3):715-721.
3. Won-Mo Yang, Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes. FEBS letters 588(13):2170-2176.
4. Marco Tomasetti, Linda Nocchi, Sara Staffolani, Nicola Manzella, Monica Amati, Jacob Goodwin, Maria Nguyen, Katarina Kluckova, Martina Bajzikova, Margaryta Sobol, Pavel Hozak, Sandra Lettlova, Jaroslav Truksa, Wan Lee, Lanfeng Dong, Lory Santarelli, Jiri Neuzil (2014) MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with Mitochondrial Function. Antioxidants & Redox Signaling 01/2014.
5. Hyo-Jin Jeong, Seung-Yoon Park, Won-Mo Yang, Wan Lee (2013) The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in cultured hepatoma cells. Biochemical and Biophysical Research Communications 434(3):503-508.
6. Seung-Yoon Park, Hyo-Jin Jeong, Won-Mo Yang, Wan Lee (2013) Implications of microRNAs in the pathogenesis of diabetes. Archives of Pharmacal Research 36(2):154-166.
7. Eun-Ju Park, Mi-Jin Kim, Wan Lee, Seung-Yoon Park (2012) Ets-2 is involved in transcriptional regulation of C1qTNF-related protein 5 in muscle cells. Molecular Biology Reports  39(10):9445-9451.
8. Mi-Jin Kim, Eun-Ju Park, Wan Lee, Jung-Eun Kim, Seung-Yoon Park (2012) Regulation of the transcriptional activation of CTRP3 in chondrocytes by c-Jun. Molecular and Cellular Biochemistry  368(1-2):111-117.
9. Mi-Jin Kim, Wan Lee, Eun-Ju Park, Seung-Yoon Park (2012) Depletion of mitochondrial DNA stabilizes C1qTNF-related protein 6 mRNA in muscle cells. Journal of Korean Medical Science  27(5):465-470.
10. Soo Lim, Sung Hee Choi, Bo Kyung Koo, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Soon Mi Choi, Man Gyoon Lee, Wan Lee, Hayley Shin, Young-Bum Kim, Hong Kyu Lee, Kyong Soo Park (2012) Effects of aerobic exercise training on C1q tumor necrosis factor α-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women. Journal of Clinical Endocrinology and Metabolism 97(1):E88-93.
11. Hyun Su Ryu, Seung-Yoon Park, Duan Ma, Jin Zhang, Wan Lee (2011) The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS ONE  6(3):e17343.
12. Hyun-Ho Hwang, Pyong-Gon Moon, Jeong-Eun Lee, Jung-Guk Kim, Wan Lee, Sung-Ho Ryu, Moon-Chang Baek (2011) Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins. Molecules and Cells 31(3):239-246.
13. Mi-Jin Kim, Wan Lee, Eun-Ju Park, Seung-Yoon Park (2010) Role of hepatocyte nuclear factor-4alpha in transcriptional regulation of C1qTNF-related protein 5 in the liver. FEBS letters  584(14):3080-3084.
14. Mi-Jin Kim, Wan Lee, Eun-Ju Park, Seung-Yoon Park (2010) C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. Molecules and Cells 30(1):59-64.
15. Wan Lee, Mi-Jin Kim, Eun-Ju Park, Young-Jin Choi, Seung-Yoon Park (2010) C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS letters 584(5):968-972.
16. Seung-Yoon Park, Jung Hyun Choi, Hyun Su Ryu, Youngmi Kim Pak, Kyong Soo Park, Hong Kyu Lee, Wan Lee (2009) C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. Journal of Biological Chemistry 284(41):27780-27789.
17. Seung-Yoon Park, Wan Lee, Jaetae Lee, In-San Kim (2008) Combination gene therapy using multidrug resistance (MDR1) gene shRNA and herpes simplex virus-thymidine kinase. Cancer Letters 261(2):205-214.
18. Wan Lee, Hyo Im Choi, Mi Jin Kim, Seung Yoon Park (2008) Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability. Experimental and Molecular Medicine  40(1):109-117.
19. Seung Y Park, Yoo H Choi, Wan Lee (2008) Dangnyohwan improves glucose utilization and reduces insulin resistance by increasing the adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima Fatty rats. Journal of Ethnopharmacology 115(3):473-482.
20. Young Ok Choi, Jong-Ha Park, Young Sook Song, Wan Lee, Yoshinori Moriyama, Han Choe, Chae Hun Leem, Yeon Jin Jang (2008) Involvement of vesicular H+-ATPase in insulin-stimulated glucose transport in 3T3-F442A adipocytes. Endocrine Journal 54(5):733-743.
21. Seung Y Park, and Wan Lee (2007) The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes. Diabetes Research and Clinical Practice 77 Suppl 1:S165-S171.
22. Seung Y. Park, Sanghyun Lee, Kyong S. Park, Hong K. Lee and Wan Lee (2006) Proteomic Analysis of Cellular Change Involved in Mitochondria-to-Nucleus Communication in L6 GLUT4myc Myocytes.  Proteomics 6, 1210-1222.
23. Young O. Choi, Hee J. Ryu, Hye R. Kim, Young S. Song, Cheon H. Kim, Wan Lee, Han Choe, Chae H. Leem, and Yeon J. Jang (2006) Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes. Exp. Mol. Med.  38:180-189.
24. Seung Y. Park, Guem H. Choi, Hyo I. Choi, Jiwon Ryu, Chan Y. Jung, and Wan Lee (2005) Depletion of mitochondrial  DNA  causes  impaired glucose utilization and  insulin resistance in L6 GLUT4myc myocytes.  J. Biol. Chem. 280 (11), 9855-9864.
25. Seung Y. Park, Jiwon Ryu, and Wan Lee (2005) O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Exp. Mol. Med.  37:220-229.
26. Seung Y. Park, Guem H. Choi, Hyo I. Choi, Jiwon Ryu, Chan Y. Jung, and Wan Lee  (2005) Calorie restriction improves whole-body glucose disposal and insulin resistance in association with the increased adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima fatty rats. Arch. Biochem. Biophys.  436:276-284.
27. Seung Y. Park, Byoung G. Ha, Guem H. Choi, Jiwon Ryu, Boemsoo Kim, Chan Y. Jung, and Wan Lee (2004) EHD2 associates with the insulin responsive glucose transporter (GLUT4) compartments in rat adipocytes and may participate in the GLUT4 recruitment. Biochemistry 43(23):7552-7562.
28. Seung Y. Park, Guem H. Choi, and Wan Lee (2004) N-Acetylated Alpha-linked Acidic Dipeptidase Expressed in Rat Adipocytes Is Localized in the Insulin Responsive Glucose Transporter (GLUT4) Intracellular Compartments and Involved in the Insulin-stimulated GLUT4 Recruitment. Arch. Biochem. Biophys. 424:11-22.
29. Jin C. Han, Seung Y. Park, Young K. Kim, Tae H. Kwon, Eui K. Kim, Moshen Lachaal, Chan Y. Jung, and Wan Lee (2003) Cadmium induces impaired glucose tolerance in rat by down-regulating GLUT4 expression in adipocytes. Arch. Biochem. Biophys.  413:213-220.
30. Jong-sik Hah, Jiwon Ryu, Wan Lee, Bum S. Kim, Robert A. Spangler, Mohsen Lachaal, and Chan Y. Jung (2002) Transient changes in four GLUT4 compartments in rat adipocytes during insulin-stimulated to basal transition; Implications for the GLUT4 trafficking pathway. Biochemistry 41(48):14364-14371.
31. Jiwon Ryu, Jong-sik Hah, James Park, Wan Lee, Amrit L. Rampal, and Chan Y. Jung CY (2002) Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91. Arch. Biochem. Biophys. 403(1):71-82.
32. Jong-sik, Jiwon Ryu, Wan Lee, Chan Y. Jung, and Mohsen Lachaal (2002) The hepatocyte glucose-6-phosphatase subcomponent T3: its relationship to GLUT2. Bioch. Biophy. Acta - Biomembranes 1564(1):198-206.
33. Wan Lee, Jiwon Ryu, Robert A. Spangler, and Chan Y. Jung (2000) Modulation of GLUT4 and GLUT1 recycling by insulin in rat adipocytes: Kinetic analysis based on four-compartment system. Biochemistry 39(31), 9358-9366.
34. Wan Lee, Mohsen Lachaal, and Chan Y. Jung (2000) Identification of proteins that may regulate GLUT4 recycling in rat adipocytes, in James M. Ntambi (ed.) : Biomedical and Health Research Vol.37. Adipocytes Biology and Hormone Signaling (ISSN:0929-6743). Amsterdam, IOS Press, 11-20.
35. Mohsen Lachaal, Amrit L. Rampal, Jiwon Ryu, Wan Lee, Jong-Sik Hah, and Chan Y. Jung (2000) Purification and partial characterization of GLUT2 in rat hepatocytes. Bioch. Biophy. Acta-Biomembranes 1466 (1-2), 379-389.
36. Wan Lee, Jiwon Ryu, Jong-Sik Hah, Takahiro Tsujita, and Chan Y. Jung (2000) Association of carboxyl esterase with GLUT4 intracellular compartments in rat adipocytes and its possible role in insulin-induced GLUT4 recruitment. J. Biol. Chem. 275 (14), 10041-10046.
37. Wan Lee, Jiwon Ryu, Ricardo Souto, Paul F. Pilch, and Chan Y. Jung (1999) Separation and partial characterization of three distinct intracellular GLUT4 compartments in rat adipocytes: Subcellular fractionation without homogenation. J. Biol. Chem. 274 (53), 37755-37762.
38. Chan Y. Jung and Wan Lee (1999) Glucose transporters and insulin action: Some insights into diabetes management. Arch. Pharmacal Res. 22:4, 329-334 (Invited Review).
39. Yanwei Shi, Jayanth Samuel, Wan Lee, Chun Yu, Wan Zhang, Mohsen Lachaal, and Chan Y. Jung (1999) Cloning of a L-3-hydroxyacyl-CoA dehydrogenase that binds to GLUT4 glucose transporter cytoplasmic C-terminus. Arch. Biochem. Biophys. 363, 3213-332.
40. Wan Lee, Jayanth Samuel, Wan Zhang, Amrit L. Rampal, Mohsen Lachaal, and Chan Y. Jung (1997) A myosin-derived peptide C109 bind to GLUT4-vesicles and inhibits the insulin-induced glucose transport stimulation and GLUT4 recruitment in rat adipocytes. Biochem. Biophys. Res. Commun. 240, 409-414.
41. Wan Lee and Chan Y. Jung (1997) A synthetic peptide corresponding to the GLUT4 carboxyl-terminal cytoplasmic domain causes insulin-like glucose transport stimulation and GLUT4 recruitment in rat adipocytes. J. Biol. Chem. 272 (34), 21427-21431.
42. Mohsen Lachaal, Amrit L. Rampal, Wan Lee, Yan-Wei Shi, and Chan Y. Jung (1996) GLUT1 transmembrane glucose pathway: Affinity labeling with a transportable D-glucose diazirine. J. Biol. Chem. 271 (9) 5225-5230.