Cancer Status: Mocb and tPSA Prostate Cancer Markers

Marian Surma

Department of Physics, Optics Laboratory, Adam Mickiewicz University, Poznań, Poland.

DOI: 10.4236/jct.2012.36144                

Abstract

On the basis of the results of magneto-optical studies and their comparison with the outcome of medical tests magneto-optical MOCB and tPSA serum markers of cancer/recovered patient are presented. Status of the cancer serum donor is recognized as presence of the laevorotatory optical active molecules of ^(-)p density in serum while status of the recovered donor is recognized as quantitative domination of the dextrorotatory ⁽⁺⁾p molecules in serum. These molecular information carriers ^(-)p and ⁽⁺⁾p are recorded by the magneto-optical circular birefringence MOCB effect in B² magnetic field. The laevo/dextrorotatory carriers are enantiomers in the case of ^(-)p = ⁽⁺⁾p relations fulfilled for any individual cancer and the same recovered patient. The positive predictive value PPV of MOCB results is 100%.

Keywords

Serum, Molecular MOCB Marker, tPSA Marke

1. Introduction

The experimental MOCB technique [1] applied for serum and enantiomers B² chirality investigation of ovarian cancer serum and the neat chiral tartaric acid were firstly published since 1997. The possibility of differentiation between the cancer and non-cancer states on the basis of the magneto-optical results has been tested [2]. The MOCB data collected suggest that the blood serum of cancer patient contains a stable bio-molecular structure. The B² effect in serum induced birefringence α(B²)^exp = (α⁺ − α⁻), where α⁺ and α⁻ denotes the B² induced optical activity of the dextroand laevorotatory molecular carriers. The physical basis of the MOCB method is that the α⁺ rotation is bearing by the dextrorotatory while the α⁻ by the leavorotatory carriers. This statement has been supported by the results [1,2] obtained for patients clinically diagnosed by standard medical treatment and by analysis of their serum magneto-optical characteristics. The later introduce pure molecular physics to the cancer marker searching while the bio-chemical methods concerns mainly a proteins.

Magneto-optical circular birefringence (MOCB) measurements indicate extraordinary result for a cancer donor and healthy donor cases despite the cancer blood donor is after successful therapy and/or donors are a different non-cancer patients. Molecular carriers in serum standing for the the magnetic field induced B² circular birefringence are carrying information on the cancer/healthy donor status by the result of experimentally measured α⁺ and α⁻.

2. Experiment

The magneto-optical rotation α(B²) induced by the B² field in the serum samples studied is described as: α(B²) = b^expB²L, where b^exp = α(B²)^exp/2B²L and L is the light path in the serum.

The serum samples have been irradiated with an argon laser beam having wave length λ = 488 nm, at T ≈ 295 K and the effective excitation volume of the serum was V_eff = 15.7 mm³.

Intensity of the magnetic field [3] acting on the serum sample was B = (15 − 30 T).

The experimental result of b^exp = α(B²)^exp/(2B²L) is a measure of serum magneto-optical birefringence expressed by the α(B²)^exp = (α⁺ − α⁻).

Magneto-optical b^exp marker, quadratic magnetic field induced circular birefringence ^(−/+)α(B²)^exp, effective natural optical activity α^exp, density number ⁽⁻⁾ρ of the laevorotatory carriers, density number ⁽⁺⁾ρ of the dextrorotatory carriers are representative for the clinically diagnosed prostate cancer patient.

Magneto-optical characteristic of serum is defined by the b^exp = b⁽⁻⁾ + b⁽⁺⁾ markers [2]. The b⁻ marker is described by the relation b^exp/⁽⁻⁾ρ = −4.114 × 10²⁸ S_q while serum magneto-optical result of b⁺ marker is described by the relation b^exp/⁽⁺⁾ρ = 2.786 × 10¹¹ R_q. where S_q and R_q denote the tensors: the electric quadrupolar and the magnetic dipolar optical polarizability of the laevorotatory and dextrorotatory molecules, respectively. The ⁽⁻⁾ρ denotes the density number of the laevoand ⁽⁺⁾ρ of the dextrorotatory carriers in blood serum standing for the magnetic field induced circular birefringence of chiral media in B² magnetic field. Magneto-optical circular birefringence (MOCB) measurements indicate extraordinary result for a cancer donor case: b⁽⁻⁾ ≠ 0, b^exp < 0 and for healthy donor case: b⁽⁺⁾ ≠ 0, b^exp > 0, despite the cancer blood donor is after successful therapy and/or donors are a different non-cancer patients.

3. Results

Table 1 gives a clear presentation of the prostate cancer diagnose and an outlook on the patient recovered status after the 45 Gy radiotherapy and 15 Gy brachytherapy processes. The laevorotatory molecular carriers quantitative MOCB representations are given by: b^exp < 0, ⁽⁻⁾ρ and S_q data of a cancer status serum and by the superimposed dextrorotatory molecular carriers in serum of the same donor after successfully therapy: b^exp > 0, ⁽⁺⁾ρ and R_q results. The α(B²)^exp, b^exp and α^exp experimental data of the cancer/healthy blood donor samples are within an experimental error of +/−5%.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	M. Surma, “Magneto-Optical Circular Birefringence of a Chiral Medium in High Magnetic Field,” Molecular Physics, Vol. 90, No. 6, 1997, pp. 993-997. doi:10.1080/00268979709482683
[2]	M. Surma, “Magnetooptical Characterization of Human Blood Serum:Correlation between Neoplasmic Changes and Their Biomolecular Information Carriers,” Physics and Chemistry of Liquids, Vol. 45, No. 3, 2007, pp. 271-279. doi:10.1080/00319100600620912
[3]	M. Surma, “Experimental Evidence of the B2 and B3 Dependent Circular Birefringence of Chiral Molecules in High Magnetic Fields,” Molecular Physics, Vol. 93, No. 2, 1998, pp. 271-278. doi:10.1080/00268979809482210
[4]	R. Zawodny, S. Wozniak, G. Wagnier’e, “On Quadratic dc Magnetic Field-Induced Circular Birefringence and Dichroism in Isotropic Chiral Media,” Molecular Physics, Vol. 91, No. 91, 1997, pp. 165-172.