[1]
|
D. M. Parkin, F. Bray, J. Ferlay et al., “Estimating the World Cancer Burden: Globocan 2000,” International Journal of Cancer, Vol. 94, No. 2, 2001, pp. 153-156.
doi:10.1002/ijc.1440
|
[2]
|
National Cancer Institute, “Egypt Cancer Registry 2002- 2003,” Cairo University, Accessed on 2 August 2011.
http://www.nci.cu.edu.eg/lectures/NCI%20registry%202002-03.pdf
|
[3]
|
A. El-Zayadi, H. Abaza, S. Shawky, et al., “Prevalence and Epidemiological Features of Hepatocellular Carcinoma in Egypt—A Single Center Experience,” Hepatology Research, Vol. 19, No. 2, 2001, pp. 170-179.
doi:10.1016/S1386-6346(00)00105-4
|
[4]
|
A. X. Zhu, “Systemic Therapy of Advanced Hepatocellular Carcinoma: How Hopeful Should We Be?” Oncologist, Vol. 11, No. 7, 2006, pp. 790-800.
doi:10.1634/theoncologist.11-7-790
|
[5]
|
J. M. Llovet, S. Ricci, V. Mazzaferro, et al., “Sorafenib in Advanced Hepatocellular Carcinoma,” The New England Journal of Medicine, Vol. 359, No. 4, 2008, pp. 378-390.
doi:10.1056/NEJMoa0708857
|
[6]
|
A. Cheng, Y. K. Kang, Z. Chen, et al., “Efficacy and Safety of Sorafenib in Patients in Asia-Pacific Region with Advanced Hepatocellular Carcinoma: A Phase III Randomised, Double-Blind, Placebo-Controlled Trial,” The Lancet Oncology, Vol. 10, No. 1, 2009, pp. 25-34.
doi:10.1016/S1470-2045(08)70285-7
|
[7]
|
G. K. Abou-Alfa, L. Schwartz, et al., “Phase II Study of Sorafenib in Patients with Advanced Hepatocellular Carcinoma,” Journal of Clinical Oncology, Vol. 24, No. 26, 2006, pp. 4293-4300. doi:10.1200/JCO.2005.01.3441
|
[8]
|
M. Nakamura, H. Nagano, S. Marubashi, et al., “Pilot Study of Combination Chemotherapy of S-1, a Novel Oral DPD Inhibitor, and Interferon-α for Advanced Hepatocellular Carcinoma with Extrahepatic Metastasis,” Cancer, Vol. 112, No. 8, 2008, pp. 1765-1771.
doi:10.1002/cncr.23356
|
[9]
|
T. Urabe, S. Kaneko, E. Matsushita, et al., “Clinical Pilot Study of Intrahepatic Arterial Chemotherapy with Methotrexate, 5-Fluorouracil, Cisplatin and Subcutaneous Interferon-Alpha-2b for Patients with Locally Advanced Hepatocellular Carcinoma,” Oncology, Vol. 55, No. 1, 1998, pp. 39-47. doi:10.1159/000011833
|
[10]
|
S. Obi, H. Yoshida, R. Toune, et al., “Combination Therapy of Intraarterial 5-Fluorouracil and Systemic Interferon-Alpha for Advanced Hepatocellular Carcinoma with Portal Venous Invasion,” Cancer, Vol. 106, No. 9, 2006, pp. 1990-1997. doi:10.1002/cncr.21832
|
[11]
|
M. A. Friedman, “Primary Hepatocellular Cancer—Pre- sent Results and Future Prospects,” International Journal of Radiation Oncology Biology Physics, Vol. 9, No. 12, 1983, pp. 1841-1850.
|
[12]
|
D. Y. Lin, S. M. Lin and Y. F. Liaw, “Non-Surgical Treatment of Hepatocellular Carcinoma,” Journal of Gastroenterology and Hepatology, Vol. 12, No. 9-10, 1997, pp. S319-S328. doi:10.1111/j.1440-1746.1997.tb00516.x
|
[13]
|
M. Miwa, M. Ura, M. Nishida, et al., “Design of a Novel Oral Fluoropyrimidine Carbamate, Capecitabine, which Generates 5-Fluorouracil Selectively in Tumors by Enzymes Concentrated in Human Liver and Cancer Tissue,” European Journal of Cancer, Vol. 34, No. 8, 1998, pp. 1274-1281. doi:10.1016/S0959-8049(98)00058-6
|
[14]
|
J. Schuller, J. Cassidy, E. Dumont, et al., “Preferential Activation of Capecitabine in Tumor Following Oral Administration to Colorectal Cancer Patients,” Cancer Chemotherapy and Pharmacology, Vol. 45, No. 4, 2000, pp. 291-297. doi:10.1007/s002800050043
|
[15]
|
Y. Z. Patt, M. M. Hassan, A. Aguayo, et al., “Oral Capecitabine for the Treatment of Hepatocellular Carcinoma, Cholangiocarcinoma, and Gallbladder Carcinoma,” Cancer, Vol. 101, No. 3, 2004, pp. 578-586.
doi:10.1002/cncr.20368
|
[16]
|
C. Twelves, R. Gynne-Jones, J. Cassidy, et al., “Effect of Hepatic Dysfunction Due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites,” Clinical Cancer Research, Vol. 5, 1999, pp. 1696-1702.
|
[17]
|
J. Folkman, “New Perspectives in Clinical Oncology from Angiogenesis Research,” European Journal of Cancer, Vol. 32, No. 14, 1996, pp. 2534-2539.
doi:10.1016/S0959-8049(96)00423-6
|
[18]
|
U. Emmenegger, S. Man, Y. Shaked, et al., “A Comparative Analysis of Low-Dose Metronomic Cyclophosphamide Reveals Absent or Low-Grade Toxicity on Tissues Highly Sensitive to the Toxic Effects of Maximum Tolerated Dose Regimens,” Cancer Research, Vol. 64, No. 11, 2004, pp. 3994-4000.
doi:10.1158/0008-5472.CAN-04-0580
|
[19]
|
R. S. Kerbel and B. A. Kamen, “The Antiangiogenicbasis of Metronomic Chemotherapy,” Nature Reviews Cancer, Vol. 4, No. 6, 2004, pp. 423-436. doi:10.1038/nrc1369
|
[20]
|
Y. Shaked, F. Bertolini, S. Man, et al., “Genetic Heterogeneity of the Vasculogenic Phenotype Parallels Angiogenesis; Implications for Cellular Surrogate Marker Analysis of Antiangiogenesis,” Cancer Cell, Vol. 7, No. 1, 2005, pp. 101-111. doi:10.1016/S1535-6108(04)00369-1
|
[21]
|
F. Bertolini, S. Paul, P. Mancuso, et al., “Maximum Tolerable Dose and Low-Dose Metronomic Chemotherapy Have Opposite Effects on the Mobilization and Viability of Circulating Endothelial Progenitor Cells,” Cancer Research, Vol. 63, No. 15, 2003, pp. 4342-4346.
|
[22]
|
G. Brandi, S. Fanello, F. Piscaglia, et al., “Metronomic Capecitabine in Advanced Patients with Hepatocellular Carcinoma (HCC): Preliminary Results,” Journal of Clinical Oncology, Vol. 25, No. 18S, 2007, p. 15163.
|
[23]
|
J. Bruix and M. Sherman, “Management of Hepatocellular Carcinoma,” Hepatology, Vol. 42, No. 5, 2005, pp. 1208-1236. doi:10.1002/hep.20933
|
[24]
|
P. R. Galle, “Sorafenib in Advanced Hepatocellular Carcinoma—We Have Won a Battle Not the War,” Journal of Hepatology, Vol. 49, No. 5, 2008, pp. 871-873.
doi:10.1016/j.jhep.2008.09.001
|
[25]
|
M. R. Stockler, T. Sourjina, P. V. Grimison, et al., “A Randomized Trial of Capecitabine (C) Given Intermittently (IC) Rather Than Continuously (CC) Compared to Classical CMF as First-Line Chemotherapy for Advanced Breast Cancer (ABC),” Journal of Clinical Oncology, Vol. 25, No. 18S, 2007, p. 1031.
|
[26]
|
S. Steinbild, J. Arends, M. Medinger, et al., “Metronomic Antiangiogenic Therapy with Capecitabine and Celecoxib in Advanced Tumor Patient—Results of a Phase II Study,” Onkologie, Vol. 30, No. 12, 2007, pp. 629-635.
|
[27]
|
M. Nannini, E. Nobili, R. Di Cicilia, et al., “Widen the Setting of Cancer Patients Who Could Benefit from Metronomic Capecitabine,” Cancer Chemotherapy and Pharmacology, Vol. 64, No. 1, 2009, pp. 189-193.
doi:10.1007/s00280-009-0930-z
|
[28]
|
G. Brandi, V. Agostini, F. de Rosa, et al., “Metronomic Capecitabine in Child-Pugh a Patients with Unresectable Hepatocellular Carcinoma,” Gastrointestinal Cancer Symposium, Orlando, 22-24 January 2010.
|
[29]
|
V. Boige, J. L. Raoul, J. P. Pignon, et al., “Multicentre Phase II Trial of Capecitabine plus Oxaliplatin (XELOX) in Patients with Advanced Hepatocellular Carcinoma: FFCD 03-03 Trial,” British Journal of Cancer, Vol. 97, 2007, pp. 862-867
|
[30]
|
A. K. Nowak, P. K. Chow and M. Findlay, “Systemic Therapy for Advanced Hepatocellular Carcinoma: A Re- view,” European Journal of Cancer, Vol. 40, No. 10, 2004, pp. 1474-1484. doi:10.1016/j.ejca.2004.02.027
|
[31]
|
I. O. Ng, C. L. Liu, S. T. Fan, et al., “Expression of P-Glycoprotein in Hepatocellular Carcinoma. A Determinant of Chemotherapy Response,” American Journal of Clinical Pathology, Vol. 113, No. 3, 2000, pp. 355-363.
|
[32]
|
E. C. Lai, T. K. Choi, C. H. Cheng, et al., “Doxorubicin for Unresectable Hepatocellular Carcinoma. A Prospective Study on the Addition of Verapamil,” Cancer, Vol. 66, No. 8, 1990, pp. 1685-1687.
doi:10.1002/1097-0142(19901015)66:8<1685::AID-CNCR2820660805>3.0.CO;2-W
|
[33]
|
T. W. Leung, Y. Z. Patt, W. Y. Lau, et al., “Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma,” Clinical Cancer Research, Vol. 5, No. 7, 1999, pp. 1676-81.
|
[34]
|
Y. Chao, W. K. Chan, M. J. Birkhofer, et al., “Phase II and Pharmacokinetic Study of Paclitaxel Therapy for Unresectable Hepatocellular Carcinoma Patients,” British Journal of Cancer, Vol. 78, No. , 1998, pp. 34-39.
doi:10.1038/bjc.1998.438
|
[35]
|
M. Hebbar, O. Ernst, S. Cattan, et al., “Phase II Trial of Docetaxel Therapy in Patients with Advanced Hepatocellular Carcinoma,” Oncology, Vol. 70, No. 2, 2006, pp. 154-158. doi:10.1159/000093007
|
[36]
|
T. S. Yang, C. H. Wang, R. K. Hsieh, et al., “Gemcitabine and Doxorubicin for the Treatment of Patients with Advanced Hepatocellular Carcinoma: A phase I-II Trial,” Annals of Oncology, Vol. 13, No. 11, 2002, pp. 1771-1778.
doi:10.1093/annonc/mdf303
|
[37]
|
Z. Guan, Y. Wang, S. Maoleekoonpairoj, et al., “Prospective Randomised Phase II Study of Gemcitabine at Standard or Fixed Dose Rate Schedule in Unresectable Hepatocellular Carcinoma,” British Journal of Cancer, Vol. 89, No. 10, 2003, pp. 1865-1869. doi:10.1038/sj.bjc.6601369
|
[38]
|
S. Louafi, V. Boige, M. Ducreux, et al., “Gemcitabine plus Oxaliplatin (GEMOX) in Patients with Advanced Hepatocellular Carcinoma (HCC): Results of a Phase II Study,” Cancer, Vol. 109, No. 7, 2007, pp. 1384-1390.
doi:10.1002/cncr.22532
|
[39]
|
T. C. Tang, S. Man, C. R. Lee, et al., “Impact of Metronomic UFT/Cyclophosphamide Chemotherapy and Anti-angiogenic Drug Assessed in a New Preclinical Model of Locally Advanced Orthotopic Hepatocellular Carcinoma,” Neoplasia, Vol. 12, No. 3, 2010, pp. 264-274.
|
[40]
|
F. de Rosa, V. Agostini, S. Di Girolamo, et al., “Metronomic Capecitabine as Second-Line Treatment for Patients with Hepatocellular Carcinoma with Preserved Liver Function: A Phase II Study,” ASCO Annual Meeting, Chicago, 1-5 June 9, 2011, p. e14608.
|