Correlation between Total PSA Level and the Histoprognostic Gleason Score

Abstract

Prostate cancer is a public health problem in Senegal. It is one of the most common cancers in men and can be detected early by PSA measurement and confirmed by the pathological study which specifies the histological type and evaluates the histoprognostic scores (Gleason and pTNM). We did not find any anatomopathological study highlighting a link between the PSA t rate and histoprognostic Gleason scores in Senegal. Objective: We carried out this work aimed at determining whether there is a correlation between the PSA t rate and the histoprognostic Gleason score, in our context. Methodology: This is a retrospective, descriptive and analytical study conducted from January 2013 to October 2021, based on histologically proven prostate cancer cases with a specified PSA level, diagnosed in the pathological anatomy and cytology laboratory of Aristide Le Dantec hospital. Results: We identified 654 cases of prostate cancer. The average age was 68.59 ± 5.8 years with extremes of 40 years to 92 years. More than half of our cohort presented a clinical stage T2c, i.e. 56.94%. The average prostate volume on ultrasound was 81.81 ± 66 cc. The median PSA t was 110.5 ng/ml, with extremes ranging from 2 ng/ml to 74,770 ng/ml. Prostatic adenocarcinoma was the only histological type found in our patients. There was a predominance of Gleason score 6 (PICU grade group 1) observed in 35.17% of patients. Well-differentiated cancers were predominant and represented 35.17%. There was a statistically significant positive correlation between PSA t level and Gleason score (Spearman’s Rho = 0.305, p = 0.000). Conclusion: This study shows that in the Senegalese population, in patients with prostate cancer, the higher the PSA t level rises above normal, the higher the Gleason score tends to be.

Share and Cite:

Senghor, F. , Thiam, I. , Ndiaye, K. and Badji, K. (2024) Correlation between Total PSA Level and the Histoprognostic Gleason Score. Open Journal of Pathology, 14, 69-80. doi: 10.4236/ojpathology.2024.142009.

1. Introduction

Prostate cancer corresponds to all malignant cell proliferations developed at the expense of prostate tissue. It can be suspected by an abnormal digital rectal examination and/or an elevated prostate specific antigen (PSA) level. Recommended individual screening consists of a prostate specific antigen (PSA) test coupled with a rectal exam every year in men aged 50 to 75 or from 45 years of age in the case of risk factors.

This condition is a public health problem. This condition corresponds to the second most common cancer and the fifth cause of cancer death among men worldwide in 2020 [1] . In Senegal, this malignant neoplasia is the most common in men, with an incidence rate of 21.8 per 100,000 men according to Globocan 2021 [2] and a frequency of 20% according to a study carried out on the state of the tumor registry in the same country between January 2010 and December 2015 [3] . The definitive diagnosis is based on anatomopathological examination, which makes it possible to assess tumor aggressiveness, its evolution and its prognosis [4] . We conducted a study aimed at studying the correlation between the total PSA level (PSA t) and the histoprognostic Gleason score cases of this pathology in Senegal.

2. Material and Method

- Type, period of study:

This is a retrospective, descriptive and analytical study over a period of eight years from January 2013 to October 2021. The study took place in the pathological anatomy and cytology laboratory (ACP) of the Aristide Le Dantec hospital (HALD) in Dakar.

- Study population:

The study population consisted of all the results, combining the report, the technical slides and the respective blocks (for each patient), archived at the HALD PCR laboratory, i.e. 64,856 patients’ results archived with their respective reports, technical slides and paraffin blocks.

- Selection criteria:

The selection of patients was carried out based on the results and respective reports of anatomopathological examinations. We included all documented cases of patients with prostate cancer confirmed histologically on biopsy or surgical specimen, with a PSA level t at the time of the diagnosis.

- Methodology:

Firstly, we consulted the registers, then analyzed the archives of the results, reports and technical slides of anatomo-pathological examinations, taking into account the inclusion criteria. Exhaustive recruitment was carried out allowing us to collect 654 cases.

When the slides were not available or unusable, we used the relevant paraffin blocks, and proceeded again with the histopathological technique until new technical slides were obtained.

Secondly, we reread the technical slides:

- The determination of the Gleason score followed the new recommendations of the prognostic grade groups adopted by the 2016 WHO classification of prostate carcinomas [5] [6] .

- The ISUP (International Society of Urological Pathology) group was determined according to the recommendations of the International Society of Urological Pathology [5] [6] . The ISUP grades were divided into 4 categories according to their degree of differentiation [5] [6] . The tumor was considered well differentiated when the ISUP score was 1, moderately differentiated for an ISUP score 2, moderately to poorly differentiated for an ISUP score 3 and poorly differentiated for an ISUP score of 4 and 5.

Data were collected identically on all histological examination reports from an Excel file. The study parameters were: age, digital rectal examination, PSA t level, prostate volume, type of sample, histological type, Gleason score, and ISUP group. The information was collected in the same way using a collection sheet developed for this purpose.

Data entry and analysis were carried out with Epi Info French version software and IBM SPSS Statistic 26 software for the descriptive analysis. The qualitative variables were described by frequency tables. The quantitative variables were described by their position (average, median) and dispersion (standard deviation, extremes) parameters. The analytical part consisted of bivariate analysis to look for associations between variables using appropriate statistical tests. The alpha error risk was set at 5%.

The correlation between the Gleason score and the PSA t level was made using the Spearman test.

The Spearman test makes it possible to specify the existence of a link between 2 quantitative variables and its intensity. The Spearman correlation coefficient (Rs) varies from −1 to +1:

- A value of p < 0.05 was considered significant, therefore concluding the existence of a correlation.

Ÿ A positive correlation (p < 0.05 and positive Rs) means that when one variable increases, the other variable also tends to increase.

Ÿ A negative correlation (p < 0.05 and negative Rs) means that when one variable increases, the other tends to decrease.

- A p value ≥ 0.05 was considered non-significant and therefore showed that there was no correlation.

3. Results

Over a period of 8 years from January 2013 to October 2021, we collected 654 cases of prostate cancer (Figure 1).

The average age was 68.59 years ± 8.29, the median 70 years with extremes of 40 and 92 years. The age group (61 - 70) was the most represented (42.64%) (Figure 2).

Figure 1. Distribution of cases according to year (N = 654).

Figure 2. Distribution of patients according to age groups (N = 598).

Clinical stage T2 was the most common (87%), divided into stage T2c (56.94%), followed by stage T2b (20.37%), then stage T4 (18.51%) (Figure 3).

The prostate volume was recorded in 50 patients (i.e. 7.65%). The average prostate volume was 81.81 cm3 ± 66.7. The median was 54 with extremes of 19.50 and 323 cm3. The average PSA t level was 867.12 ng/ml ± 3489.32. The median was 110.5 ng/ml with extremes of 2 and 74,770 ng/ml. Patients with a PSA t level greater than 50 ng/ml were the most represented, i.e. in 70.03% (458 cases) (Figure 4).

Biopsy was the main type of sample found (91.6%) followed by surgical specimens (8.4%). The only histological type highlighted was prostatic adenocarcinoma. The Gleason score (3 + 3) = 6 was the most represented, i.e. 35.17% (230 cases), followed by the score (4 + 3) = 7 representing 30.89% and the Gleason score 8 (4 + 4) or 22.18% (145 cases). Gleason score 5 + 5 = 10 was the least representing 0.15% (1 case) (Figure 5).

Figure 3. Distribution of patients according to clinical stage (N = 216).

Figure 4. Distribution of patients according to PSA t levels (N = 654).

Figure 5. Distribution of patients according to Gleason score (N = 654).

Group ISUP 1 was the most common (35.17%), followed by ISUP 3 (31.04%) then ISUP 5 (3.21%) (Figure 6).

The different correlations were studied using the Spearman correlation coefficient (Spearman’s Rho). The study finds a monotonic positive correlation between the PSA t level and respectively the Gleason score (Rs = 0.305; n = 654; p < 0.001), the ISUP grade group (Rs = 0.303 n = 654, p < 0.001) and the degree of differentiation (Rs = 0.306; n = 654; p < 0.001) (Table 1).

The comparison of the averages and medians of the PSA level according to the degree of differentiation, supports the results of the correlation and shows that the PSA t tends to increase when the tumor becomes less differentiated (Figure 7).

No correlation was found (p value > 0.05) between age and, respectively, Gleason score, PSA t level and rectal examination (Table 2).

Figure 6. Distribution of patients according to their ISUP grade.

Figure 7. Comparison of averages, standard deviations, medians of PSA t according to the degree of differentiation.

Table 1. Comparative table of the results of the Spearman correlation between the PSA t level and the Gleason score, the ISUP grade group and the degree of differentiation.

Table 2. Comparative table of the results of the Spearman correlation between age and PSA t level, TR results and Gleason score.

4. Discussion

In Senegal, according to Globocan 2020, prostate cancer is the most common cancer in men. This condition generally affects men in the sixth decade, in Black Africa and particularly in Senegal, as evidenced by the average age in our study and several series in Nigeria, Togo and Senegal (Table 3).

However, the proportion of prostate cancers in subjects under 50 years of age may be worrying. Several studies show an increase in this proportion with the wider use of PSA testing, going from 1% according to studies carried out by Alexander et al. in 1987 [11] and Aprikian et al. in 1994 [12] to 4.5% according to the study by Parker et al. in 2011 [13] . The PSA assay being relatively used in Senegal and Africa, this would explain the rates of 1.84% and 1.7% of patients aged less than 50 years, found respectively in our cohort and that of Mohammed et al. [8] in Nigeria. In our context, a little more than 12% of patients are part of the active population (<65 years). A significant proportion (3.78%) had a benign prostate on rectal examination, associating an isolated increase in the PSA t level and thus allowing the indication for a prostate biopsy. According to Catalona et al. [14] 23% to 45% of cancers would be unrecognized if the indications for biopsies were based solely on digital rectal examination because several prostate cancers do not cause palpable changes.

Prostate cancer in black Africa is frequently associated with a significant elevation in PSA t, often greater than 10 times normal, as corroborated by our work as well as several West African studies [7] [15] [16] [17] . This observation confirms the diagnostic delay (a long evolution of the disease before diagnosis), especially since the PSA level is correlated with the clinical stage [18] , it increases with the extension of the disease (Table 4).

The indication for prostate biopsy based on the PSA level has been known since the work of Stamey in 1989; for this, the threshold value most used in the

Table 3. Comparison of the average age and extremes of CaP cases from various series.

Table 4. Comparison of the average PSA t of various series.

literature is 4 ng/ml. Only in our series, two patients (0.31%) had a PSA t level below 4 ng/ml, but showed abnormalities on digital rectal examination (cT2), indicating prostate biopsy. This same type of observation was also noted by Gurumurthy et al. [19] , Mohammed et al. [9] . Thus it appears necessary to couple the PSA t level to the clinical examination and more particularly to the rectal examination for efficient screening. Although the PSA level has good sensitivity for this condi-tion, when it is greater than 4 ng/ml, the probability of finding prostate cancer below the threshold of 2 ng/mL and a PSA level between 2.5 and 4 ng/mL is 2% and 18% respectively [20] . Some experts have therefore proposed lowering the threshold value from which the biopsy must be performed to 2.5 ng/mL in order to improve early detection of cancer [21] .

Our cohort, as well as several series, found a large predominance of the cT2c class at more than 50%, such as the study of Ndiaye [22] (51%) and Niang et al. [7] (61.1%). A significant proportion of our patients presented with advanced cancer (18.5%). This trend is found in the studies of Ndiaye et al. [9] , Gueye et al. [18] and Amegbor et al. [10] . The cause would be the late diagnosis of pros-tate cancer secondary to [9] :

- The absence of organized systematic screening for prostate cancer;

- The absence of individual screening in patients with a family past history of prostate cancer;

- Accessibility to health structures, cost of examinations;

- Delay in patient consultation in African populations.

Prostatic adenocarcinoma is the most common histological type of prostate cancer. Several studies confirm this [15] [23] . This predominance can be explained by the fact that the prostate is composed mainly of glandular tissue. According to McNeal [24] prostate cancers develop preferentially (68%) in the peripheral zone which is made up of 70% glandular tissue. There are other rarer histological types such as sarcoma, including a case reported by Niang et al. [7] .

Gleason 6 (3 + 3) is often the most common, as shown by our work and the studies of Okolo et al. [25] , Čamdžić et al. [26] , while Niang et al. [7] observed a preponderance of Gleason score 7 (3 + 4) (ISUP group 2).

Data from the literature frequently shows that there is a statistically significant correlation between the elevation of the PSA t level and the elevation of the Gleason score as demonstrated in our study (Table 5).

Our data show that more PSA t rated, the more the ISUP group was raised and the more cancer was dedifferentiated. Some authors such as Blackwell et al. [29] , explain these findings with a theory, “although individually the cells of a poorly differentiated prostatic adenocarcinoma produce less PSA than those of a well and moderately differentiated adenocarcinoma, they are generally presenting such large numbers, that the PSA t level is higher”.

The study by Partin et al. [30] , on the other hand, found a negative correlation between the PSA t rate and the Gleason score.

This work could present limitations which we were able to identify as follows:

- This is a monocentric retrospective study, although the HALD laboratory is one of the two public laboratories receiving the most prostate histological samples in Senegal, and these samples come from all regions.

- We did not carry out a control group to compare PSA levels and Gleason scores in men without prostate cancer.

- Genetic, environmental and comorbidity factors were not considered in the study.

- The study did not include a longitudinal follow-up of prostate cancer patients in relation to initial PSA levels and Gleason scores, because several patients died or were lost to follow-up.

This study may have some limitations, which we have identified as follows:

- This is a retrospective monocentric study, although the HALD laboratory is one of the two public laboratories receiving the most prostate histological samples in Senegal, and these samples come from all regions.

Table 5. Comparison of the p value of the correlation between the elevation of the PSA t level and the elevation of the Gleason score of various series.

- We did not use a control group to compare PSA levels and Gleason scores in men without prostate cancer.

- Genetic, environmental and comorbidity factors were not taken into account in the study.

- The study did not include long-term follow-up of prostate cancer patients in relation to baseline PSA levels and Gleason scores, as many patients died or were lost to follow-up.

5. Conclusions

Prostate cancer in Senegal occurs preferentially in men in their sixth decade with a high PSA t level. Our study shows that there is a statistically significant correlation between elevated PSA t and elevated Gleason score.

The PSA t level should be considered in our context as a useful tool for both detecting and suggesting the aggressiveness of prostate cancer.

Conflicts of Interest

The authors declare no conflicts of interest regarding the publication of this paper.

References

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660
[2] IARC/OMS (2021) Global Cancer Observatory. Cancer Today.
https://gco.iarc.fr/today/online-analysismap?v=2020&mode=population&mode_population=continents&population=900&populations=900&key=asr&sex=1&cancer=27&type=0&statistic=5&prevalence=0&population_group=0&ages_group[]=0&ages_group[]=17&nb_items=10&gr
[3] Bouri, N.V., Ba, O., Dieme, J.L., Mbengue, M., Boye, A., Fall, T., et al. (2017) Inventory of Fixtures of the Tumor Registry in Senegal: Assessment after 6 Years of Online Registration. Journal of Respiratory Diseases, 34, A75.
https://doi.org/10.1016/j.rmr.2016.10.156
[4] Fournier, G., Valeri, A., Mangin, P. and Cussenot, O. (2004) Prostate Cancer. Epidemiology. Risk Factors. Anatomopathology. Annals of Urology, 38, 187-206.
https://doi.org/10.1016/j.anuro.2004.07.001
[5] Kumar, V., Abbas, A.K. and Aster, J.C. (2014) Robbins and Cotran Pathologic Basis of Disease, Professional Edition E-Book. 9th Edition, Elsevier, New York.
[6] Camilo, A. and Thomas, P. (2016) Mémento de pathologie. 4e Édition, Éditions Vernazobres-Grego, Paris.
[7] Niang, L., Ndoye, M., Ouattara, A., Jalloh, M., Labou, M., Thiam, I., et al. (2013) Cancer de la prostate : Quelle prise en charge au Sénégal ? Progrès en Urologie, 23, 36-41.
https://doi.org/10.1016/j.purol.2012.09.002
[8] Mohammed, U., Rasheed, M.W., Adegboye, A.T., Abdullahi, K., Sahabi, S.M., To, M., et al. (2024) Correlation of Serum PSA with Gleason Score and Gleason Group Grade in Patients with Prostate Adenocarcinoma at Sokoto North-Western Nigeria. International Journal of Recent Innovations in Medicine and Clinical Research, 2, 6-13.
https://doi.org/10.18231/j.ijrimcr.2024.002
[9] Ndiaye, M., Sow, O., Thiam, A., Sarr, A., Gaye, O., Sine, B., et al. (2020) Cancer de la prostate au Centre Hospitalier Universitaire Aristidie Le Dantec de Dakar : Aspects épidemiologiques sur les cinq dernières années. Annales Africaines de Médecine, 14, e4004-e4009.
[10] Amégbor, K., Yao Seddoh, T., Tengué, K., Songne-Gnamkoulamba, B., Napo-Koura, G. AND James, K. (2009) Épidémiologie et histopronostic du cancer de la prostate au Togo : À propos de 202 cas diagnostiqués au laboratoire d’anatomie pathologique du CHU Tokoin de Lomé. Progrès en Urologie, 19, 112-115.
https://doi.org/10.1016/j.purol.2008.10.008
[11] Alexander, R.B., Maguire, M.G., Epstein, J.I. and Walsh, P.C. (1989) Pathological Stage Is Higher in Older Men with Clinical Stage B1 Adenocarcinoma of the Prostate. Journal of Urology, 141, 880-882.
https://doi.org/10.1016/S0022-5347(17)41038-X
[12] Aprikian, A.G., Zhang, Z.F. and Fair, W.R. (1994) Prostate Adenocarcinoma in Men Younger than 50 Years. A Retrospective Review of 151 Patients. Cancer, 74, 1768-1777.
https://doi.org/10.1002/1097-0142(19940915)74:6<1768::AID-CNCR2820740620>3.0.CO;2-9
[13] Parker, P.M., Rice, K.R., Sterbis, J.R., Chen, Y., Cullen, J., McLeod, D.G., et al. (2011) Prostate Cancer in Men Less than the Age of 50: A Comparison of Race and Outcomes. Urology, 78, 110-115.
https://doi.org/10.1016/j.urology.2010.12.046
[14] Catalona, W.J., Richie, J.P., Ahmann, F.R., Hudson, M.A., Scardino, P.T., Flanigan, R.C., et al. (1994) Comparison of Digital Rectal Examination and Serum Prostate Specific Antigen in the Early Detection of Prostate Cancer: Results of a Multicenter Clinical Trial of 6,630 Men. Journal of Urology, 151, 1283-1290.
https://doi.org/10.1016/S0022-5347(17)35233-3
[15] Jalloh, M., Thiaw, G., Bathily, E.H.A.L., Dial, C., Ndoye, M., Diallo, A., et al. (2018) Corrélation entre score de Gleason biopsique et métastases osseuses à la scintigraphie dans le cancer de la prostate. Revue Africaine dUrologie et dAndrologie, 1, 501-508.
[16] Kabore, F.A., Zango, B., Sanou, A., Yameogo, C. and Kirakoya, B. (2011) Prostate Cancer Outcome in Burkina Faso. Infectious Agents and Cancer, 6, Article No. S6.
https://doi.org/10.1186/1750-9378-6-S2-S6
[17] Loko, F., Hodonou, R., Akpaka, R., Hounnasso, P., Adisso, S. and Akpo, C. (2011) Valeur predictive du PSA dans le diagnostic du cancer de la prostate chez les sujets Beninois. International Journal of Biological and Chemical Sciences, 5, 512-523.
https://doi.org/10.4314/ijbcs.v5i2.72096
[18] Gueye, S.M., Jalloh, M., Labou, I., Niang, L., Kane, R. and Ndoye, M. (2004) Profil clinique du cancer de la prostate au Sénégal. African Journal of Urology, 10, 203-207.
[19] Gurumurthy, D., Maggad, R. and Patel, S. (2015) Prostate Carcinoma: Correlation of Histopathology with Serum Prostate Specific Antigen. Science Journal of Clinical Medicine, 4, 1-5.
https://doi.org/10.11648/j.sjcm.s.2015040401.11
[20] Epstein, J.I. and Netto, G.J. (2014) Biopsy Interpretation of the Prostate. Lippincott Williams & Wilkins, Philadelphia.
[21] Gretzer, M.B. and Partin, A.W. (2003) PSA Markers in Prostate Cancer Detection. Urologic Clinics of North America, 30, 677-686.
https://doi.org/10.1016/S0094-0143(03)00057-0
[22] Ndiaye, M. (2018) Cancers prostatiques métastatiques sous hormonothérapie : Facteurs influençant la résistance à la castration. Master’s Thesis, Cheikh Anta Diop, Dakar.
[23] Ndong, B., Mbodj, M., Mbaye, G., Ndoye, O., Bathily, E.H.A.L., Diouf, L.A.D., et al. (2012) Place de la scintigraphie osseuse dans le bilan d’extension des métastases des cancers de la prostate au Sénégal: Étude préliminaire à propos de 45 cas. Médecine Nucléaire, 36, 586-590.
https://doi.org/10.1016/j.mednuc.2012.05.012
[24] McNeal, J.E. (1969) Origin and Development of Carcinoma in the Prostate. Cancer, 23, 24-34.
https://doi.org/10.1002/1097-0142(196901)23:1<24::AID-CNCR2820230103>3.0.CO;2-1
[25] Okolo, C.A., Akinosun, O.M., Shittu, O.B., Olapade-Olaopa, E.O., Okeke, L.I., Akang, E.E.U., et al. (2008) Correlation of Serum PSA and Gleason Score in Nigerian Men with Prostate Cancer. African Journal of Urology, 14, 15-22.
https://doi.org/10.1007/BF02994508
[26] Čamdžić, N., Kuskunović-Vlahovljak, S., Dorić, M., Radović, S., Lazović Salčin, E. and Babić, M. (2021) Serum Total Prostate-Specific Antigen (tPSA): Correlation with Diagnosis and Grading of Prostate Cancer in Core Needle Biopsy. Medicinski Glasnik, 18, 122-127.
[27] Yarney, J., Vanderpuye, V. and Mensah, J. (2013) Clinicopathologic Features and Determinants of Gleason Score of Prostate Cancer in Ghanaian Men. Urologic Oncology: Seminars and Original Investigations, 31, 325-330.
https://doi.org/10.1016/j.urolonc.2011.01.018
[28] Lovely, J., Suma, M.T., Santa, S. and Soudan, V.M. (2017) Gleason’s Grading of Carcinoma Prostate with PSA Correlation. JMSCR, 5, 27634-27639.
https://doi.org/10.18535/jmscr/v5i9.44
[29] Blackwell, K.L., Bostwick, D.G., Myers, R.P., Zincke, H. and Oesterling, J.E. (1994) Combining Prostate Specific Antigen with Cancer and Gland Volume to Predict more Reliably Pathological Stage: The Influence of Prostate Specific Antigen Cancer Density. Journal of Urology, 151, 1565-1570.
https://doi.org/10.1016/S0022-5347(17)35303-X
[30] Partin, A.W., Carter, H.B., Chan, D.W., Epstein, J.I., Oesterling, J.E., Rock, R.C., et al. (1990) Prostate Specific Antigen in the Staging of Localized Prostate Cancer: Influence of Tumor Differentiation, Tumor Volume and Benign Hyperplasia. Journal of Urology, 143, 747-752.
https://doi.org/10.1016/S0022-5347(17)40079-6

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.