Email: joao.fernandes@unifesp.br

Qualifications
2012 Ph.D., University of São Paulo, Medicinal Chemistry

2006 M.Sc., University of São Paulo, Medicinal Chemistry
2003 B.Pharm., Guarulhos University, Pharmacy

Publications (Selected)

1. Brito, I. A., Levatti, E. V. C., Regasini, L. O., Ferreira, E. A., Lopes, F. B., Fernandes, J. P. S., ... & Lago, J. H. G. (2025). Homologous acetylenic acetogenins from Porcelia macrocarpa RE (Fries) displayed potent activity against amastigotes from Trypanosoma cruzi. Phytochemistry, 231, 114360.
2. Lustoza, F. D., & Fernandes, J. P. S. (2025). Assessing the impact of clinically relevant medicinal chemistry teaching: Learning gains from case study approach. Brazilian Journal of Pharmaceutical Sciences, 61, e24499.
3. Lopes, F. B., Fernandes, J. P. S., & Uliassi, E. (2024). Tackling Neuroinflammation in Cognitive Disorders with Single-targeted and Multi-targeted Histamine H3 Receptor Modulators. Current Topics in Medicinal Chemistry, 24(28), 2421-2430.
4. Roquini, D. B., Lemes, B. L., Kreutz, A. L., Spoladore, S. C., Amaro, M. C., Lopes, F. B., ... & de Moraes, J. (2024). Antihistamines H1 as potential anthelmintic agents against the zoonotic parasite Angiostrongylus cantonensis. ACS omega, 9(28), 31159-31165.
5. Ospital, I. A., Delgado, M. A. T., Nicoud, M. B., Corrêa, M. F., Fernandes, G. A. B., Andrade, I. W., ... & Medina, V. A. (2024). Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer. Biomedicine & Pharmacotherapy, 174, 116527.
6. Varela, M. T., de Castro Levatti, E. V., Tempone, A. G., & Fernandes, J. P. S. (2023). Investigation of Structure–Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors. ACS omega, 8(46), 44265-44275.
7. Varela, M. T., Romanelli, M., Amaral, M., Tempone, A. G., & Fernandes, J. P. S. (2023). Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity. Saudi Pharmaceutical Journal, 31(7), 1265-1273.
8. Mengarda, A. C., Silva, T. C., Silva, A. S., Roquini, D. B., Fernandes, J. P. S., & de Moraes, J. (2023). Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments. European Journal of Medicinal Chemistry, 251, 115268.
9. de Castro Levatti, E. V., Costa-Silva, T. A., Morais, T. R., Fernandes, J. P. S., Lago, J. H. G., & Tempone, A. G. (2023). Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism. Biochimie, 208, 141-150.
10. Aranha, C. M., Reiner-Link, D., Leitzbach, L. R., Lopes, F. B., Stark, H., & Fernandes, J. P. S. (2023). Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors. Bioorganic & Medicinal Chemistry, 78, 117132.
11. Carmo-Martins, J. I., Gonzatti, M. B., Varela, M. T., Sousa, M. E. P., Costa, L. V., Rodrigues, E. G., ... & Keller, A. C. (2023). Esterification of p-coumaric acid improves the control over melanoma cell growth. Biomedicines, 11(1), 196.
12. Dos Santos, L. A., Dos Santos, G. S., Fernandes, G. A. B., Corrêa, M. F., de Faria Almeida, C. A., Fernandes, L., ... & Garcia, R. C. T. (2022). Neurotoxicity assessment of 1-[(2, 3-Dihydro-1-Benzofuran-2-yl) Methyl] Piperazine (LINS01 Series) derivatives and their protective effect on cocaine-induced neurotoxicity model in SH-SY5Y cell culture. Neurotoxicity Research, 40(6), 1653-1663.
13. Lopes, F. B., Aranha, C. M., Corrêa, M. F., Fernandes, G. A., Okamoto, D. N., Simões, L. P., ... & Fernandes, J. P. S. (2022). Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies. Chemical Biology & Drug Design, 100(5), 722-729.
14. Varela, M. T., Amaral, M., Romanelli, M. M., de Castro Levatti, E. V., Tempone, A. G., & Fernandes, J. P. S. (2022). Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi. European Journal of Pharmaceutical Sciences, 171, 106114.
15. Waller, S. B., Cleff, M. B., Ripoll, M. K., Meireles, M. C. A., Ferrarini, M., Varela, M. T., & Fernandes, J. P. S. (2022). Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis. Chemical Biology & Drug Design, 99(3), 391-397.
16. Lopes, F. B., Aranha, C. M., & Fernandes, J. P. S. (2021). Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands. Chemical Biology & Drug Design, 98(2), 212-225.

Profile Details

Web of Science ResearcherID: H-3617-2012

https://orcid.org/0000-0002-9089-273X

https://scholar.google.com.hk/citations?hl=zh-CN&user=X6qx6xAAAAAJ

https://www.researchgate.net/profile/Joao-Fernandes-43