Wuhan University School of Medicine, China

Email: zhangxiaolian@whu.edu.cn

Qualifications

1997 Ph.D., Hongkong University of Science and Technology, Hongkong, China

1989 M.S., Wuhan University, Wuhan, China

1986 B.S., Wuhan University, Wuhan, China

Publications (Selected)

1. Qu, H. R., Wang, C. Q., Sun, S. J., Zhang, W. W., Liu, C. H., Du, X. S., ... & Liu, M. (2025). Bioinformatics Identification of Lactate‐Associated Genes in Hepatocellular Carcinoma: G6PD's Role in Immune Modulation. Cancer Medicine, 14(6), e70801.
2. Guan, Q., Xiong, H., Song, X., Liu, S., Guang, Y., Nie, Q., ... & Zhang, X. L. (2025). Suppression of NLRP3 inflammasome by a small molecule targeting CK1α–β-catenin–NF-κB and CK1α–NRF2–mitochondrial OXPHOS pathways during mycobacterial infection. Frontiers in Immunology, 16, 1553093.
3. Li, Z. L., Xie, Y., Wang, Y., Wang, J., Zhou, X., & Zhang, X. L. (2025). NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication. Genomics, Proteomics & Bioinformatics, qzaf008.
4. Pan, Q., & Zhang, X. L. (2024). Roles of core fucosylation modification in immune system and diseases. Cell Insight, 100211.
5. Li, Z. L., Xie, Y., Xie, Y., Chen, H., Zhou, X., Liu, M., & Zhang, X. L. (2024). HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1. ACS Chemical Biology, 19(7), 1648-1660.
6. Jin, Y., Liu, J., Zhou, Y., Chen, R., Chen, H., Duan, W., ... & Zhang, X. L. (2024). CRDet: A circle representation detector for lung granulomas based on multi-scale attention features with center point calibration. Computerized Medical Imaging and Graphics, 113, 102354.
7. Wu, J., Luo, F. L., Xie, Y., Xiong, H., Gao, Y., Liu, G., & Zhang, X. L. (2022). EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway. Frontiers in Immunology, 13, 943174.
8. Dou, Y., Xie, Y., Zhang, L., Liu, S., Xu, D., Wei, Y., ... & Zhang, X. L. (2022). Host MKRN1-mediated mycobacterial PPE protein ubiquitination suppresses innate immune response. Frontiers in immunology, 13, 880315.
9. Yao, Q., Xie, Y., Xu, D., Qu, Z., Wu, J., Zhou, Y., ... & Zhang, X. L. (2022). Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3. Cellular & Molecular Immunology, 19(8), 883-897.
10. Kong, Y., Chen, H., Chen, M., Li, Y., Li, J., Liu, Q., ... & Zhang, X. L. (2022). Abnormal ECA-binding membrane glycans and galactosylated CAT and P4HB in lesion tissues as potential biomarkers for hepatocellular carcinoma diagnosis. Frontiers in Oncology, 12, 855952.
11. Kong, Y., Mao, C., Li, S., Xie, Y., Zhang, X. L., & Fu, B. (2022). A Novel Imidazolinone Derivative with 5‐Arylidene and 2‐Substituted Mercapto Group as Potent Anti‐Hepatitis C Virus Compound. Chemistry & Biodiversity, 19(2), e202100602.
12. Zhou, Y., Xiong, H., Chen, R., Wan, L., Kong, Y., Rao, J., ... & Zhang, X. L. (2021). Aptamer detection of mycobaterium tuberculosis mannose-capped lipoarabinomannan in lesion tissues for tuberculosis diagnosis. Frontiers in Cellular and Infection Microbiology, 11, 634915.
13. Xie, Y., Zhou, Y., Liu, S., & Zhang, X. L. (2021). PE_PGRS: Vital proteins in promoting mycobacterial survival and modulating host immunity and metabolism. Cellular Microbiology, 23(3), e13290.
14. Qu, Z., Zhou, J., Zhou, Y., Xie, Y., Jiang, Y., Wu, J., ... & Zhang, X. L. (2020). Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway. Science advances, 6(43), eaba4733.
15. Liu, C. G., Wang, Y., Liu, P., Yao, Q. L., Zhou, Y. Y., Li, C. F., ... & Zhang, X. L. (2020). Aptamer-T cell targeted therapy for tumor treatment using sugar metabolism and click chemistry. ACS Chemical Biology, 15(6), 1554-1565.
16. Liu, M., Chen, H. Y., Luo, L., Wang, Y., Zhang, D., Song, N., ... & Pan, Q. (2020). Neutralization of IL‐10 produced by B cells promotes protective immunity during persistent HCV infection in humanized mice. European Journal of Immunology, 50(9), 1350-1361.
17. Liu, S., Xie, Y., Luo, W., Dou, Y., Xiong, H., Xiao, Z., & Zhang, X. L. (2020). PE_PGRS31-S100A9 interaction promotes mycobacterial survival in macrophages through the regulation of NF-κB-TNF-α signaling and arachidonic acid metabolism. Frontiers in microbiology, 11, 845.

Profile Details

https://orcid.org/0000-0002-8283-9381

https://mri.whu.edu.cn/info/3531/30931.htm

https://loop.frontiersin.org/people/396256/overview

https://www.researchgate.net/profile/Xiao-Lian-Zhang