Advances in Antimicrobial Peptides
Antimicrobial peptides (AMPs), also called host defence peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between prokaryotic and eukaryotic cells that may represent targets for antimicrobial peptides. These peptides are potent, broad spectrum antimicrobials which demonstrate potential as novel therapeutic agents. Antimicrobial peptides have been demonstrated to kill Gram negative and Gram positive bacteria, enveloped viruses, fungi and even transformed or cancerous cells. Unlike the majority of conventional antibiotics it appears that antimicrobial peptides frequently destabilize biological membranes, can form transmembrane channels, and may also have the ability to enhance immunity by functioning as immunomodulators.
In the present book, ten typical literatures about antimicrobial peptides published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on antimicrobial peptides. We hope this book can demonstrate advances in antimicrobial peptides as well as give references to the researchers, students and other related people.
Sample Chapter(s)
Preface (179 KB)
Components of the Book:
  • Chapter 1
    Enhancing the Antimicrobial Properties of Peptides through Cell-Penetrating Peptide Conjugation A Comprehensive Assessment
  • Chapter 2
    Combating Gram-negative infections: The role of antimicrobial peptides and nanotechnology in overcoming antibiotic resistance
  • Chapter 3
    Modified CLEC3A-Derived Antimicrobial Peptides Lead to Enhanced Antimicrobial Activity against Drug-Resistant Bacteria
  • Chapter 4
    Exploring the Antimicrobial and Antiviral Properties of Cryptic Peptides from Human Fibrinogen
  • Chapter 5
    Membrane Modification and Adaptation of Metabolism by Acinetobacter baumannii Prompts Resistance to Antimicrobial Activity of Outer Membrane Perturbing Peptide L8
  • Chapter 6
    Advances in antimicrobial peptides: From mechanistic insights to chemical modifications
  • Chapter 7
    Dimer Is Not Double The Unexpected Behavior of Two-Floor Peptide Nanosponge
  • Chapter 8
    Antimicrobial peptides in nematode secretions – Unveiling biotechnological opportunities for therapeutics and beyond
  • Chapter 9
    A dual-mechanism antimicrobial peptide with antimutagenic activity targets the replisome and induces cell envelope stress
  • Chapter 10
    Cubosome lipid nanocarriers for delivery of ultra-short antimicrobial peptides
Readership: Students, academics, teachers and other people attending or interested in a antimicrobial p eptides.
Hélder A. Santos
Department of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, Groningen, 9713 AV, the Netherlands

Denise Meinberger
Institute for Clinical Chemistry, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany

Felix Paulussen
Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands

and more...
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