RNA therapeutics are a new class of medications based on ribonucleic acid (RNA). Research has been working on clinical use since the 1990s, with significant success in cancer therapy in the early 2010s. In 2020 and 2021, mRNA vaccines have been developed globally for use in combating the coronavirus disease (COVID-19 pandemic). The Pfizer–BioNTech COVID-19 vaccine was the first mRNA vaccine approved by a medicines regulator, followed by the Moderna COVID-19 vaccine, and others. The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers.

In the present book, ten typical literatures about RNA therapeutics published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on RNA therapeutics. We hope this book can demonstrate advances in RNA therapeutics as well as give references to the researchers, students and other related people.