Gas Chromatography-Mass Spectrometry with Cold EI: Leading the Way to the Future of GC-MS
Gas chromatography-mass spectrometry (GC-MS) with supersonic molecular beams (SMB) (also named GC-MS with Cold EI) is based on GC and MS interface with a SMB and on the electron ionization (EI) of vibrationally cold analytes in the SMB (hence the name Cold EI) in a contact-free fly-through ion source. Cold EI improves all the central GC-MS performance aspects and brings a broad range of important benefits thereby leading the way to the future of GC-MS. Cold EI provides enhanced molecular ions combined with effective library-basedsample identification. Sample identification is further improved by the use of powerful TAMI software that is based on isotope abundance analysis and improved quadrupole mass accuracy for the provision of the sample elemental formula from its molecular ion group of isotopologues.
Components of the Book:
  • Head Page
  • Copyright
  • Abstract
  • Content
  • Chapter 1 Background
  • Chapter 2 Experimental—The GC-MS with Cold EI Systems
  • Chapter 3 Cold Electron Ionization (Cold EI)
  • Chapter 4 Sample Identification via Its Cold EI Mass Spectrum by the NIST Library
  • Chapter 5 Cold EI versus Low Electron Energy EI
  • Chapter 6 Classical EI with the SMB System
  • Chapter 7 Isotope Abundance Analysis (IAA) for the Provision of Elemental Formula from Cold EI Mass Spectra
  • Chapter 8 Isomer Mass Spectral Effects and Isomer Distribution Analysis
  • Chapter 9 Improved Sample Identification via Its Cold EI Mass Spectrum
  • Chapter 10 Cluster Chemical Ionization with SMB
  • Chapter 11 Extending the Range of Compounds Amenable for Analysis—Healing the Achilles Heel of GC‐MS
  • Chapter 12 Uniform Compound Independent Ion Source Response and Its Benefits
  • Chapter 13 Sensitivity and Limits of Detection
  • Chapter 14 Speed—Fast GC‐MS with Cold EI
  • Chapter 15 Pulsed Flow Modulation Comprehensive Two Dimensional GCxGC‐MS with Cold EI
  • Chapter 16 Enhancement Technologies for GC-MS with Cold EI
  • Chapter 17 Hyperthermal Surface Ionization
  • Chapter 18 ChromatoProbe Sample Introduction Device
  • Chapter 19 Low Thermal Mass Fast GC for Ultra-Fast GC-MS
  • Chapter 20 Open Probe Fast GC‐MS—Real Time Analysis with Separation and Library Identification
  • Chapter 21 Electron Ionization LC‐MS with Cold EI and GC‐MS and LC‐MS in One MS System
  • Chapter 22 GC‐MS‐MS with Cold EI
  • Chapter 23 Photoionization of Cold Molecules in SMB (Cold PI)
  • Chapter 24 GC-MS with Cold EI Maintenance, Flexibility, Ease of Use and Price
  • Chapter 25 Selected Applications of GC-MS with Cold EI
  • Chapter 26 Hydrocarbons Analysis
  • Chapter 27 Organic Chemistry Service Analysis
  • Chapter 28 Oil Analysis for Its Diglycerides and Triglycerides Content
  • Chapter 29 Lipids in Human Blood Analysis for Medical Diagnostics
  • Chapter 30 Beeswax Analysis and the Challenge of Material Identification
  • Chapter 31 Forensic and Homeland Security Explosives Analysis
  • Chapter 32 Cannabis and Cannabinoids Analysis
  • Chapter 33 Drugs Impurities Analysis
  • Chapter 34 Pesticides Analysis in Agricultural Products
  • Chapter 35 Nonoxinol‐9 Condom Spermicide Analysis
  • Chapter 36 Flavonoids in a Plant Extract Analysis
  • Chapter 37 Discussion and Conclusions
  • Acknowledgements
  • Epilogue
  • Bibliography
Readership: Students, academics, teachers and other people attending or interested in Gas Chromatography.
1
Head Page
Aviv Amirav
PDF (50 KB)
3
Copyright
Aviv Amirav
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4
Abstract
Aviv Amirav
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7
Content
Aviv Amirav
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Chapter 1 Background
Aviv Amirav
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19
Chapter 2 Experimental—The GC-MS with Cold EI Systems
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25
Chapter 3 Cold Electron Ionization (Cold EI)
Aviv Amirav
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Chapter 4 Sample Identification via Its Cold EI Mass Spectrum by the NIST Library
Aviv Amirav
PDF (273 KB)
35
Chapter 5 Cold EI versus Low Electron Energy EI
Aviv Amirav
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40
Chapter 6 Classical EI with the SMB System
Aviv Amirav
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Chapter 7 Isotope Abundance Analysis (IAA) for the Provision of Elemental Formula from Cold EI Mass Spectra
Aviv Amirav
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52
Chapter 8 Isomer Mass Spectral Effects and Isomer Distribution Analysis
Aviv Amirav
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Chapter 9 Improved Sample Identification via Its Cold EI Mass Spectrum
Aviv Amirav
PDF (134 KB)
60
Chapter 10 Cluster Chemical Ionization with SMB
Aviv Amirav
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65
Chapter 11 Extending the Range of Compounds Amenable for Analysis—Healing the Achilles Heel of GC‐MS
Aviv Amirav
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Chapter 12 Uniform Compound Independent Ion Source Response and Its Benefits
Aviv Amirav
PDF (385 KB)
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Chapter 13 Sensitivity and Limits of Detection
Aviv Amirav
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Chapter 14 Speed—Fast GC‐MS with Cold EI
Aviv Amirav
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103
Chapter 15 Pulsed Flow Modulation Comprehensive Two Dimensional GCxGC‐MS with Cold EI
Aviv Amirav
PDF (357 KB)
113
Chapter 16 Enhancement Technologies for GC-MS with Cold EI
Aviv Amirav
PDF (120 KB)
114
Chapter 17 Hyperthermal Surface Ionization
Aviv Amirav
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117
Chapter 18 ChromatoProbe Sample Introduction Device
Aviv Amirav
PDF (309 KB)
122
Chapter 19 Low Thermal Mass Fast GC for Ultra-Fast GC-MS
Aviv Amirav
PDF (162 KB)
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Chapter 20 Open Probe Fast GC‐MS—Real Time Analysis with Separation and Library Identification
Aviv Amirav
PDF (305 KB)
128
Chapter 21 Electron Ionization LC‐MS with Cold EI and GC‐MS and LC‐MS in One MS System
Aviv Amirav
PDF (692 KB)
134
Chapter 22 GC‐MS‐MS with Cold EI
Aviv Amirav
PDF (367 KB)
141
Chapter 23 Photoionization of Cold Molecules in SMB (Cold PI)
Aviv Amirav
PDF (354 KB)
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Chapter 24 GC-MS with Cold EI Maintenance, Flexibility, Ease of Use and Price
Aviv Amirav
PDF (652 KB)
159
Chapter 25 Selected Applications of GC-MS with Cold EI
Aviv Amirav
PDF (120 KB)
160
Chapter 26 Hydrocarbons Analysis
Aviv Amirav
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166
Chapter 27 Organic Chemistry Service Analysis
Aviv Amirav
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171
Chapter 28 Oil Analysis for Its Diglycerides and Triglycerides Content
Aviv Amirav
PDF (425 KB)
175
Chapter 29 Lipids in Human Blood Analysis for Medical Diagnostics
Aviv Amirav
PDF (554 KB)
181
Chapter 30 Beeswax Analysis and the Challenge of Material Identification
Aviv Amirav
PDF (353 KB)
185
Chapter 31 Forensic and Homeland Security Explosives Analysis
Aviv Amirav
PDF (412 KB)
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Chapter 32 Cannabis and Cannabinoids Analysis
Aviv Amirav
PDF (688 KB)
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Chapter 33 Drugs Impurities Analysis
Aviv Amirav
PDF (611 KB)
204
Chapter 34 Pesticides Analysis in Agricultural Products
Aviv Amirav
PDF (527 KB)
208
Chapter 35 Nonoxinol‐9 Condom Spermicide Analysis
Aviv Amirav
PDF (366 KB)
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Chapter 36 Flavonoids in a Plant Extract Analysis
Aviv Amirav
PDF (531 KB)
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Chapter 37 Discussion and Conclusions
Aviv Amirav
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Acknowledgements
Aviv Amirav
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Epilogue
Aviv Amirav
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228
Bibliography
Aviv Amirav
PDF (260 KB)
Aviv Amirav
School of Chemistry, Tel Aviv University, Tel Aviv 6997801, Israel.
Aviv Analytical Ltd. 24 Hanagar Street, Hod Hasharon 4527713 Israel.
Email: amirav@tau.ac.il (March 31, 2021)

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