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  • 347pp. Published July 2017
  • Scientific Research Publishing, Inc.,USA.
  • Category: Biomedical & Life Sciences
  • ISBN: 978-1-61896-424-3
  • (Hardcover) USD 109.00
  • ISBN: 978-1-61896-423-6
  • (Paperback) USD 89.00
Authors/Editors Price: 40% off
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Home > Books > Advances in GTPases
Advances in GTPases
  • Description
  • Author(s) Information

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases. The hydrolysis of the γ phosphate of GTP into guanosine diphosphate (GDP) and Pi, inorganic phosphate, occurs by the SN2 mechanism (see nucleophilic substitution) via a pentavalent intermediate state and is dependent on the magnesium ion Mg2+.

Components of the Book:
  • Chapter 1
    Regulation of mitochondrial trafficking, function and quality control by the mitochondrial GTPases Miro1 and Miro2
  • Chapter 2
    Increased expression of ARF GTPases in prostate cancer tissue
  • Chapter 3
    The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of life
  • Chapter 4
    A paneukaryotic genomic analysis of the small GTPase RABL2 underscores the significance of recurrent gene loss in eukaryote evolution
  • Chapter 5
    CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling
  • Chapter 6
    Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells
  • Chapter 7
    Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas
  • Chapter 8
    Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2
  • Chapter 10
    Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis
Readership: Students, academics, teachers and other people attending or interested in GTPases.
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