2D Numerical Simulation of Liver Cell Proliferation with Angiogenesis for Hepatic Lobule Formation

Katsuya Nagayama¹, Hiroto Tanaka¹, Yuki Oshiumi¹, Nana Shirakigawa², Hiroyuki Ijima²

¹Kyushu Institute of Technology, Fukuoka, Japan.
²Kyushu University, Fukuoka, Japan.

DOI: 10.4236/jbm.2016.43007                

Abstract

The liver has the ability to reform and regenerate in our body. However, the mechanisms of reformation or regeneration of the liver have not been elucidated. In this study, we propose an analysis model using a Particle Model to elucidate the mechanism of liver formation. The object of analysis is a hepatic lobule, which is the basic component of the liver. First, a 2-dimensional cell proliferation around one blood vessel was modeled. Second, angiogenesis was added and considered. And finally, the model was applied to the hepatic lobule and the 2D formation of the hepatic lobule was revealed. We used experimentally derived parameters such as diffusivity, oxygen concentration, and oxygen consumption of a cell. The model will be expected to facilitate in developing tissue-engineered liver using regenerative medicine technology.

Keywords

Particle Simulation, Liver Proliferation, Angiogenesis

Conflicts of Interest

The authors declare no conflicts of interest.

References

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