Family tree and population: Distinction and similarity of the analysis on example of hemophilia

Andrey N. Volobuev, Peter I. Romanchuk, Vladimir K. Malishev

Samara State Medical University, Samara, Russia.

DOI: 10.4236/ns.2013.59119                

Abstract

On the basis of Hardy-Weinberg law the distinction in the philosophy of the description of a family tree and a population is considered. With the help of introduction of the equivalent constant mutagen factor both in a family tree and in a population, the analysis of hemophilia is led. Influence of selection at presence of hemophilia is considered. On the basis of idea of Danforth and Haldane about the balance mutagenesis and selection at presence of hemophilia, the inter-relation of selection parameter and the equivalent constant mutagen factor is found. It is shown, that dynamics of development of hemophilia in a family tree and in population are similar.

Keywords

Alleles; Equivalent Constant Mutagen Factor; Family Tree; Population; Hemophilia;Balance of Selection and Mutagenesis

Conflicts of Interest

The authors declare no conflicts of interest.

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