Genetic variation may play a crucial role in non-coding RNA biogenesis

Jeyalakshmi Kandhavelu¹, Meenakshisundaram Kandhavelu^2*

¹School of Veterinary Medicine, University of Camerino, Camerino, Italy.
²Department of Signal Processing, Tampere University of Technology, Tampere, Finland.

DOI: 10.4236/ajmb.2012.24040                

Abstract

Transcription, post-transcriptional modification, translation, post-translational modification, DNA replication, and signaling interaction of intra- and extra- cellular components are the relevant mechanisms in gene regulation. Transcription is one of the most important mechanisms in the control of gene expression. Further, post-transcriptional modifications play a crucial role after transcription which determine whether the transcribed gene is coding or non-coding RNA (ncRNAs). Genome-wide analysis of RNAs provides information about the coding RNAs, whereas the status of ncRNAs are still at large and must be discussed in detail as variations in the ncRNAs can lead to different phenotypes. In this short article, we discuss the role of genetic variation in ncRNA genes and how this variation may play a crucial role in ncRNA biogenesis that eventually leads to phenotypic variation and thus speciation.

Keywords

Genome Wide Analysis; Bioinformatics; Genetic Variation; Non-Coding RNA Biogenesis; RNA Structure; Speciation

Conflicts of Interest

The authors declare no conflicts of interest.

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