Author(s)

Laila M. Break¹, Mosselhi A. M. Mohamed^1,2*, Ohoud A. A. Al-Thubaiti¹, Fatma E. M. Eibaih³

¹Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, Taif, KSA.
²Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
³Department of Chemistry, Faculty of Science, King Saud University, Riyadh, KSA.

Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.

Synthesis, Nucleosides, Pyrimidines, Fused Pyrimidines Heterocycles, Biological Activity

Break, L. , Mohamed, M. , Al-Thubaiti, O. and Eibaih, F. (2019) Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity. International Journal of Organic Chemistry, 9, 107-120. doi: 10.4236/ijoc.2019.93010.