Melanin, the main photoreceptor in living organics, is largely abundant in pigmented hair tissues. Its promising properties have been widely studied in order to fully explore the corresponding applications. However, the photodegradating and aggregating natures of melanin, to some extent, restrict the development of this eco-friendly biomaterial. This study is conducted to overcome both disadvantages by a mature method that coating the original melanin nanoparticles with silica as shells. The results revealed that the aggregation of the melanin/silica nanoparticles (MSNP) was decreased obviously by a 5 h coating and appeared a uniformly mono-dispersed solution. The MSNP that coated for 20 h provided an efficient protection on the photodegradation of the melanin with a 50% maintenance of the melanin content compared with 16% of original melanin and 2% of MSNP-5 h.