Author(s)

Kun-I Lin¹, Li-Wu Chiang¹, Cheng-Tse Pan¹, Ho-Lien Huang¹, Yuan-Hsiao Su¹, Shui-Tein Chen², Ying-Cheng Huang³, Chung-Shan Yu^4*

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu City.
²Institute of Biological Chemistry, Academia Sinica, Taipei City.
³Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan City.
⁴Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taoyuan City.

6-azidogalactosyl imidate has been used as a donor to generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library extension from the azido group.

Glycosylation; Chemoselective; Imidate; Building Block; Lactoside

K. Lin, L. Chiang, C. Pan, H. Huang, Y. Su, S. Chen, Y. Huang and C. Yu, "6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 74-86. doi: 10.4236/ojmc.2013.33010.