Comparison of Lipid Peroxidation and Anti-Oxidant Ac-tivities in Pre-Eclamptic & Normal Pregnancies in Nigerian Population - International Journal of Clinical Medicine

IJCM > Vol.4 No.5, May 2013

Comparison of Lipid Peroxidation and Anti-Oxidant Ac-tivities in Pre-Eclamptic & Normal Pregnancies in Nigerian Population ()

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DOI: 10.4236/ijcm.2013.45042 3,145 Downloads 4,826 Views Citations

Author(s)

Adetunji O. Adeniji, Dolapo P. Oparinde

Affiliation(s)

Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria..
Department of Obstetrics & Gynaecology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.

ABSTRACT

Purpose: To compare the serum malondialdehyde (MDA) and total antioxidant status in women with preeclampsia and normal pregnancy in our environment. Materials & Methods: This was a 3-year, cross-sectional, case control study of 100 preeclamptic and 200 normotensive pregnant women at Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol was reviewed and approved by our Institutional Ethical Review Committee and all participants gave their consent. The fasting serum of recruited patients were analysed for Malondialdehyde (MDA) with rapid, sensitive and specific Thiobarbituric Acid (TBA) assay, while the Total Antioxidant status (TAS) was determined using the capacity of the biological fluids to inhibit the production of thiobarbituric acid reactive substances (TBARS) from sodium benzoate under the influence of the free oxygen radicals derived from Fenton’s reaction. Results: The mean serum MDA was significantly higher in the preeclamptic group (2.96 nmol/ mL) than the value recorded (1.23 nmol/mL) in the control group (P = 0.0001). Conversely, significantly lower mean TAS (0.46 nmol/mL vs 0.62 nmol/mL) was noticed in the preeclamptic group (P = 0.0001). Conclusion: The study showed significant increase in lipid peroxidation and failure of compensatory antioxidant functions in preeclamptic pregnant Nigerian women.

KEYWORDS

Lipid Peroxidation; Anti-Oxidant Status; Preeclampsia; Malondialdehyde

Share and Cite:

A. Adeniji and D. Oparinde, "Comparison of Lipid Peroxidation and Anti-Oxidant Ac-tivities in Pre-Eclamptic & Normal Pregnancies in Nigerian Population," International Journal of Clinical Medicine, Vol. 4 No. 5, 2013, pp. 239-243. doi: 10.4236/ijcm.2013.45042.

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