Dr. Kambiz N. Alavian
School of Medicine
Section of Endocrinology and Metabolism
Department of Internal Medicine
Yale University, USA
Associate Research Scientist
Email: kambiz.alavian@yale.edu
Qualifications
2003-2006 Ph.D., University of Heidelberg, Neuroscience
2002-2003 M.S., Illinois Institute of Technology, Biology
1999-2001 B.S., University of Illinois at Chicago, Biology
Publications (selected)
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Thuret, S., Alavian, K.N., Gassmann, M., Lloyd, C.K., Smits, S.M., Smidt, M.P., Klein, R., Dyck, R.H. and Simon, H.H., The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem, 2004. 91(6): p. 1302-1311.
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Sgado, P., Alberi, L., Gherbassi, D., Galasso, S.L., Ramakers, G.M., Alavian, K.N., Smidt, M.P., Dyck, R.H. and Simon, H.H., Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A, 2006. 103(41): p. 15242-15247.
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Alavian, K.N., Scholz, C. and Simon, H.H., Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord, 2008. 23(3): p. 319-328. (review)
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Alavian, K.N., Sgado, P., Alberi, L., Subramaniam, S., and Simon, H.H., Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev, 2009. 4: p. 11.
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Alavian, K.N. and Simon, H.H., Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database. Mol Neurodegener, 2009. 4: p. 6.
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Pruszak, J., Ludwig, W., Blak, A., Alavian, K. and Isacson, O., CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells, 2009. 27(12): p. 2928-2940.
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Simon, H.H. and Alavian, K.N., Transcriptional regulation of their survival: the Engrailed homeobox genes. Adv Exp Med Biol, 2009. 651: p. 66-72. (book chapter)
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Chung, C.Y., Licznerski, P., Alavian, K.N., Simeone, A., Lin, Z., Martin, E., Vance, J. and Isacson, O., The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain, 2010. 133:2022-2031.
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Sanchez, C.E., Tierney, T.S., Gale, J.T., Alavian, K.N., Sahin, A., Lee, J.S., Mulligan, R.C. and Carter, B.S., Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg, 2010. 114(3): p. 672-680.
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Vahedi, S., Rajabian, M., Misaghian, A., Grbec, D., Simon, H.H. and Alavian, K.N., Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. J Biomed Sci, 2010. 17: p. 66.
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Alavian, K.N., Li, H., Collis, L., Bonanni, L., Zeng, L., Sacchetti, S., Lazrove, E., Nabili, P., Flaherty, B., Graham, M., Chen, Y., Messerli, S.M., Mariggio, M.A., Rahner, C., McNay, E., Shore, G.C., Smith, P.J., Hardwick, J.M. and Jonas, E.A., Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase. Nature Cell Biol, 2011. 13(10): p. 1224-1233.
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Chen, Y.B., Aon, M.A., Hsu, Y.T., Soane, L., Teng, X., McCaffery, J.M., Cheng, W.C., Qi, B., Li, H., Alavian, K.N., Dayhoff-Brannigan, M., Zou, S., Pineda, F.J., O'Rourke, B., Ko, Y.H., Pedersen, P.L., Kaczmarek, L.K., Jonas, E.A. and Hardwick, J.M., Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal of Cell Biology, 2011. 195(2), 263-276.
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Ofengeim, D., Chen, Y.-B., Miyawaki T, Li, H., Sacchetti, S., Flannery, R., Alavian, K.N., Pontarelli, F., Hickman, J.A., Hardwick, J.M., Zukin, R.S. and Jonas, E.A., N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neuroscience, 2012. 10.1038/nn.3054.
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Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Mangold, J., Signore, A., DeMarco, U., Damady, D., Smith, P.J.S., Gribkoff, V.K. and Jonas, E.A., Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Research, 2012. 10.1016/j.brainres.2012.01.046.
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Gray, J.P., Alavian, K.N., Jonas, E.A. and Heart, E.A. (2012). NAD kinase (NADK) regulates the size of NADPH pool and insulin secretion in pancreatic beta cells. Am J Physiol Endocrinol Metab. 2012. doi:10.1152/ajpendo.00465.2011.
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Li, H., Alavian, K.N., Lazrove, E., Mehta, N., Jones, A., Zhang, P., Licznerski, P., Graham, M., Uo, T., Duman, R.S., Morrison, R.S., Rahner, C. and Jonas, E.A., A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Under revision, Nature Cell Biology.
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Alavian, K.N., Lazrove, E., Nabili, P., Li, H. and Jonas, E.A., A non-selective ion channel within the C-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Submitted to Nature.
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Licznerski, P., Duric, V., Banasr, M., Alavian, K.N., Jonas, E.A. and Duman, R.S., Serum and glucocorticoid-induced Kinase- (SGK) in post-traumatic stress disorder and depression. Under revision for Science.
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Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Mangold, J., Signore, A., DeMarco, U., Damady, D., Smith, P.J.S., Gribkoff, V.K., Jonas, E.A. Dexpramipexole (KNS-760704) inhibits stress-induced mitochondrial membrane conductance and improves cellular bioenergetic efficiency. Under revision.
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Alavian, K.N., Lazrove, E. and Jonas E.A. DJ1 regulates neuronal metabolic efficiency through modulation of the mitochondrial inner membrane potional. In preparation.
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Jonas. E.A., Chatterjee, G., Zhang, P., Alavian, K.N., Carrithers, L.M. and Carrithers, M.D., Electrophysiological Characterization of an Endosomal Macrophage Splice Variant of the Human SCN5A Sodium Channel. In preparation.
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Alavian, K.N., Tierney T.S., Pruszak, J., Ludwig, W., Hargus, G., Astradsson, A. and Isacson, O. P53-mediated cell cycle arrest prevents tumorigenesis in human embryonic stem cell-derived dopaminergic grafts. In preparation.
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