Dr. Jian-Jun Wei
Department of Pathology
Department of Obstatrics and Gynecology
Feinberg School of Medicine
Northwestern University, USA
Email: jianjun-wei@northwestern.edu
Qualifications
1982-1985 M.D., Clinic Medicine, Huabei Coal Medical College, China
1977-1982 M.S., Medical Genetics, Shandong Medical University, China
Publications (Selected)
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STC2overexpression mediated byHMGA2is a
biomarker for aggressiveness of high-grade serous ovarian cancerJingjing Wu, Maode
Lai, Changshun Shao, Jian Wang and Jian-Jun Wei. Oncology Report. 2015
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Spontaneous
transformation of murine oviductal epithelial cells: A model system to
investigate the onset of fallopian-derived tumors MIchael P.
Endsley, Georgette Moyle-Heyrman, Subbulakshmi Karthikeyan, Daniel D. Lantvit,
David A. Davis, Jian-Jun Wei and Joanna E Burdette Frontier Oncology 2015
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Tumorigenesis and peritoneal colonization from fallopian
tube epithelium. Sharon L. Eddie, Suzanne M. Quartuccio, Eoghainin Ó.
hAinmhire, Georgette Moyle-Heyrman, Dan D. Lantvit, Jian-Jun Wei, Vanderhydenand Joanna E. BurdetteBarbara C. Oncotarget.
2015.
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Mutant p53 expression
in fallopian tube epithelium drives cell migration. Suzanne M. Quartuccio,
Subbulakshmi Karthikeyan, Sharon L. Eddie, Daniel D. Lantvit, Eoghain, O
Ainmhire, Dimple A. Modi, Jian-Jun Wei and Joanna E. Burdette. Internat J
Cancer 2015
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Differential
expression of miRNAs in uterine leiomyoma and adjacent myometrium of different
races Z Liu, H Guo, J Wu,S
Ghanny, H
Guo, E Marsh, S Bulun, J Zavadil, P Soteropoulos, JJ Wei*. Am J Gyn Oncol 2015
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LEF1
Targeting EMT in Prostate Cancer Invasion is Regulated by miR-34a. Liang J, Li
Y, Daniels G, Sfanos K, De Marzo A, Wei JJ, Li X, Cheng W, Wang J, Zhong X,
Melamed J, Zhao J, Lee P. Mol Cancer Res. 2015 Jan 13. pii:
molcanres.0503.2014. [Epub ahead of print] PubMed PMID: 25587085.
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Integrated
analysis of long noncoding RNAs and mRNAs reveals their potential roles in the
pathogenesis of uterine leiomyomas. Guo H, Zhang X, Dong R, Liu X, Li Y, Lu S,
Xu L, Wang Y, Wang X, Hou D, Wei JJ, Shao C, Liu Z. Oncotarget. 2014 Aug 16.
PubMed PMID: 25268745.
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Ovarian steroids, stem cells and uterine leiomyoma: Therapeutic
implications. Moravek MB, Yin P, Ono M, Coon VJS, Dyson MT, Navarro A, Marsh EE,
Chakravarti D, Julie Kim J, Wei J-J, Bulun SE. Human Reproduction Update. 2015
Jan;21(1):1-2. ISSN: 13554786
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Establishment of human patient-derived endometrial cancer xenografts in
NOD scid gamma mice for the study of invasion and metastasis. Unno K, Ono
M, Winder AD, Maniar KP, Paintal AS, Yu Y, Wei J-J, Lurain JR, Kim JJ. PLoS
ONE. 2014 Dec 26;9(12): ISSN: 19326203
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5-hydroxymethylcytosine promotes proliferation of human uterine
leiomyoma: A biological link to a new epigenetic modification in benign tumors. Navarro A,
Yin P, Ono M, Monsivais D, Moravek MB, Coon JSV, Dyson MT, Wei J-J, Bulun SE.
Journal of Clinical Endocrinology and Metabolism. 2014 Nov;99(11):E2437-E2445.
PMID:25057885ISSN: 0021972X
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A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4
Methylation on Histone H3 during Androgen Signaling and in Prostate CancerKim J-Y,
Banerjee T, Vinckevicius A, Luo Q, Parker JB, Baker MR, Radhakrishnan I, Wei
J-J, Barish GD, Chakravarti D. Molecular Cell. 2014 May 22;54(4):613-625. PMID:24793694PMCID: 24793694 ISSN: 10972765
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Inactivation of AKT induces cellular senescence in uterine leiomyomaXu X, Lu Z,
Qiang W, Vidimar V, Kong B, Kim JJ, Wei J-J*. Endocrinology. 2014 Apr;155(4):1510-1519.
PMID:24476133PMCID: 24476133 ISSN: 00137227
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Down-regulation of miR-29b is essential for pathogenesis of uterine
leiomyomaQiang W, Liu Z, Serna VA, Druschitz SA, Liu Y, Espona-Fiedler M, Wei J-J*,
Kurita T. Endocrinology. 2014 Mar;155(3):663-669. PMID:24424054PMCID: 24424054 ISSN: 00137227
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Advances in serous tubal intraepithelial carcinoma: Correlation with high
grade serous carcinoma and ovarian carcinogenesisLi H-X, Lu
Z-H, Shen K, Cheng W-J, Malpica A, Zhang J, Wei J-J, Zhang Z-H, Liu J.
International Journal of Clinical and Experimental Pathology. 2014
Jan;7(3):848-857. PMID:24696706PMCID: 24696706 ISSN: 19362625
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Decreased expression of stromal estrogen receptor α and β in prostate
cancerDaniels G, Lin
Gellert L, Melamed J, Hatcher D, Li Y, Wei J, Wang J, Lee P. American Journal
of Translational Research. 2014 Jan;6(2):140-146. ISSN: 19438141
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Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: An
in vivo study in orthotopic xenografts of nude miceXu X, Ayub B,
Liu Z, Serna VA, Qiang W, Liu Y, Hernando E, Zabludoff S, Kurita T, Kong B, Wei
J-J*. Molecular Cancer Therapeutics. 2014 Jan;13(7):1729-1739.
MCT-13-0982.ISSN: 15357163
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Epithelial and stromal expression of miRNAs during prostate cancer
progressionRen Q, Liang J, Wei J, Basturk O, Wang J, Daniels G, Gellert LL, Li Y,
Osman I, Zhao J, Melamed J, Lee P. American Journal of Translational Research.
2014 Jan;6(4):329-339. ISSN: 19438141
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ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation
via Ras-like and estrogen-regulated growth inhibitor in endometriosisMonsivais D,
Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei
JJ, Pavone ME, Su E, Bulun SE. Molecular Endocrinology. 2014
Jan;28(8):1304-1315. ISSN: 08888809
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MED12 and HMGA2 mutations: Two independent genetic events in uterine
leiomyoma and leiomyosarcomaBertsch E, Qiang W, Zhang Q, Espona-Fiedler M, Druschitz
S, Liu Y, Mittal K, Kong B, Kurita T, Wei J-J*. Modern Pathology. 2014
Jan;27(8):1144-1153. ISSN: 08933952
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Molecular analyses of 6 different types of uterine smooth muscle tumors:
Emphasis in atypical leiomyomaZhang Q, Ubago J, Li L, Guo H, Liu Y, Qiang W, Kim JJ,
Kong B, Wei J-J*. Cancer. 2014 Jan;120(20):3165-3177. ISSN: 0008543X
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Integrated analysis of long noncoding RNAs and mRNAs reveals their
potential roles in the pathogenesis of uterine leiomyomasGuo H, Zhang
X, Dong R, Liu X, Li Y, Lu S, Xu L, Wang Y, Wang X, Hou D, Wei J-J, Shao C, Liu
Z. Oncotarget. 2014 Jan;5(18):8625-8636. ISSN: 19492553
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miR-145 inhibits tumor growth and metastasis by targeting metadherin in
high-grade serous ovarian carcinomaDong R, Liu X, Zhang Q, Jiang Z, Li Y,
Wei Y, Li Y, Yang Q, Liu J, Wei J-J, Shao C, Liu Z, Kong B. Oncotarget. 2014
Jan;5(21):10816-10829. ISSN: 19492553
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Histologic and immunohistochemical analyses of endometrial carcinomasWei J-J,
Paintal A, Keh P. Archives of Pathology and Laboratory Medicine. 2013
Nov;137(11):1574-1583. PMID:24168495ISSN: 00039985
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MK-2206, an AKT inhibitor, promotes caspase-independent cell death and
inhibits leiomyoma growthSefton EC, Qiang W, Serna V, Kurita T, Wei J-J,
Chakravarti D, Kim JJ. Endocrinology. 2013 Nov;154(11):4046-4057. PMID:24002033PMCID: 24002033 ISSN: 00137227
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MiR-106a represses the RB tumor suppressor p130 to regulate cellular
proliferation and differentiation in High-grade serous ovarian carcinomaLiu Z,
Gersbach E, Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C, Wei J-J*.
Molecular Cancer Research. 2013 Nov;11(11):1314-1325. PMID:24045973PMCID: 24045973 ISSN: 15417786
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HMGA2 and high-grade serous ovarian carcinomaWu J, Wei J-J*.
Journal of Molecular Medicine. 2013 Oct;91(10):1155-1165. PMID:23686260ISSN: 09462716
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Dual Pten/Tp53 suppression promotes sarcoma progression by activating
Notch signalingGuijarro MV, Dahiya S, Danielson LS, Segura MF,
Vales-Lara FM, Menendez S, Popiolek D, Mittal K, Wei JJ, Zavadil J,
Cordon-Cardo C, Pandolfi PP, Hernando E. American Journal of Pathology. 2013
Jun;182(6):2015-2027. PMID:23708211PMCID: 23708211 ISSN: 00029440
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Functional Domains of Androgen Receptor Coactivator p44/Mep50/WDR77and
Its Interaction with Smad1Li Y, Tian L, Ligr M, Daniels G, Peng Y, Wu X, Singh M, Wei
J, Shao Y, Lepor H, Xu R, Chang Z, Wang Z, Lee P. PLoS ONE. 2013 May
29;8(5):doi:10.1371/journal.pone. 0064663. PMID:23734213PMCID: 23734213 ISSN: 19326203
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Expression analysis of MIR182 and its associated target genes in advanced
ovarian carcinomaMcMillen BD, Aponte MM, Liu Z, Helenowski IB, Scholtens
DM, Buttin BM, Wei J-J*. Modern Pathology. 2012 Dec;25(12):1644-1653. PMID:22790015ISSN: 08933952
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MiR-182 overexpression in tumourigenesis of high-grade serous ovarian
carcinomaLiu Z, Liu J, Segura MF, Shao C, Lee P, Gong Y, Hernando E, Wei J-J*.
Journal of Pathology. 2012 Oct;228(2):204-215. PMID:22322863ISSN: 00223417
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Mucinous adenocarcinoma developed from human fallopian tube epithelial
cells through defined genetic modificationsShan W, Mercado-Uribe I, Zhang J,
Rosen D, Zhang S, Wei J, Liu J. Cell Cycle. 2012 Jun;11(11):2107-2113. PMID:22592533PMCID: 22592533 ISSN: 15384101
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USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating
Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic
DevelopmentLin Z, Yang H, Kong Q, Li J, Lee S-M, Gao B, Dong H, Wei J, Song J, Zhang
DD, Fang D. Molecular Cell. 2012 May 25;46(4):484-494. PMID:22542455ISSN: 10972765
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A transcriptional regulatory role of the THAP11-HCF-1 complex in colon
cancer cell functionParker JB, Palchaudhuri S, Yin H, Wei J, Chakravarti D.
Molecular and Cellular Biology. 2012 May;32(9):1654-1670. PMID:22371484PMCID: 22371484 ISSN: 02707306
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Genome-wide DNA methylation indicates silencing of tumor suppressor genes
in uterine leiomyomaNavarro A, Yin P, Monsivais D, Lin SM, Du P, Wei J-J,
Bulun SE. PLoS ONE. 2012 Mar 13;7(3):doi:10.1371/journal.pone.0033284. PMID:22428009PMCID: 22428009 ISSN: 19326203
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Increased activation of the PI3K/AKT pathway compromises decidualization
of stromal cells from endometriosisYin X, Pavone ME, Lu Z, Wei J, Kim JJ.
Journal of Clinical Endocrinology and Metabolism. 2012 Jan;97(1):E35-E43. PMID:22072736PMCID: 22072736 ISSN: 0021972X
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Endometriosis and ovarian cancer: A review of clinical, pathologic, and
molecular aspectsWei J-J*, William J, Bulun S.
International Journal of Gynecological Pathology. 2011 Nov;30(6):553-568. PMID:21979592PMCID: 21979592 ISSN: 02771691
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Expression and function of androgen receptor coactivator p44/MEP50/WDR77
in ovarian cancerLigr M, Patwa RR, Daniels G, Pan L, Wu X, Li Y, Tian L,
Wang Z, Xu R, Wu J, Chen F, Liu J, Wei J-J, Lee P. PLoS ONE. 2011 Oct 13;6(10):
PMID:22022581PMCID: 22022581 ISSN: 19326203
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Local lymph node micrometastasis in a patient with negative sentinel
lymph node biopsies after lymphatic mapping with wide local excision of primary
melanoma on the head/neck areaQuerfeld C, Wayne JD, Wei J-J, Abdul-Nabi A, Gerami P.
American Journal of Dermatopathology. 2011 Oct;33(7):745-748. PMID:21946765ISSN: 01931091
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Distinct function of androgen receptor coactivator ARA70α and ARA70β in
mammary gland development, and in breast cancerWu X, Chen F, Sahin A, Albarracin C,
Pei Z, Zou X, Singh B, Xu R, Daniels G, Li Y, Wei J, Blake M, Schneider RJ,
Cowin P, Lee P. Breast Cancer Research and Treatment. 2011 Jul;128(2):391-400.
PMID:20814820ISSN: 01676806
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Regulation of HMGA1 expression by MicroRNA-296 affects prostate cancer
growth and invasionWei J-J, Wu X, Peng Y, Shi G, Olca B, Yang X, Daniels G,
Osman I, Ouyang J, Hernando E, Pellicer A, Rhim JS, Melamed J, Lee P. Clinical
Cancer Research. 2011 Mar 15;17(6):1297-1305.
PMID:21138859PMCID: 21138859 ISSN: 10780432