Dr. John Kolega

State University of New York, USA

Email: john.johnz@gmail.com

Qualifications

1984 Ph.D., Yale University, New Haven, USA
1981 M.Sc., Yale University, New Haven, USA
1978 B.Sc., Massachusetts Institute of Technology, USA

Publications (Selected)

1. H. Meng, E. Metaxa, L. Gao, N. Liaw, S. K. Natarajan, D. D. Swartz, A. H. Siddiqui, J. Kolega, J. Mocco. (2011) Progressive aneurysm development following hemodynamic insult.  J. Neurosurgery 114: 1095-1103.
2. Tanweer, E. Metaxa, N. Liaw, D. S. Sternberg, A. H. Siddiqui, J. Kolega, H. Meng. (2011) Inhibition of Stretch-activated Ion Channels on Endothelial Cells Disrupts Nitric Oxide-mediated Arterial Outward Remodeling. J. Biorheology 24: 77-83.
3. J. Dolan, H. Meng, S. Singh, R. Paluch, J. Kolega. (2011) High fluid shear stress and spatial shear stress gradients affect endothelial proliferation, survival and alignment. Ann. Biomed. Res. 39:1620-1631.
4. J. Kolega, L. Gao, M. Mandelbaum, J. Mocco, A. H. Siddiqui, S. K. Natarajan, H. Meng. (2011) Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model.  J. Vascular Res. 48:429-442.
5. M. Tremmel, J. Xiang, Y. Hoi, J. Kolega, A. H. Siddiqui, J. Mocco, H. Meng. (2010) Mapping vascular response to in vivo hemodynamics: application to increased flow at the basilar terminus. Biomech. Model Mechanobiol. 9:421-434.
6. E. Metaxa, M. Tremmel, S. K. Natarajan, J. Xiang, R. Paluch, M. Mandelbaum, A. H. Siddiqui, J. Kolega, J. Mocco, H. Meng. (2010) Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model. Stroke 41: 1774-1782.
7. C. N. Ionita, A. M. Paciorek, A. Dohatcu, K. R. Hoffman, D. R. Bednarik, J. Kolega, E. I. Levy, L. N. Hopkins, S. Rudin, J. D. Mocco. (2009) The Asymmetric Vascular Stent. Efficacy in a rabbit aneurysm model. Stroke 40:959-965.
8. Z. Wang, J. Kolega, Y. Hoi, L. Gao, D. D. Swartz, E. I. Levy, J. Mocco, H. Meng. (2009) Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation. Neurosurgery 65:169-178.
9. C. N. Ionita, A. M. Paciorek, K. R. Hoffman, D. R. Bednarik, J. Yamamoto, J. Kolega, E. I. Levy, L. N. Hopkins, S. Rudin, J. Mocco. (2008) Asymmetric Vascular Stent (AVS): Feasibility Study of a New Low-porosity Patch-containing Stent. Stroke 39:2105-2113.
10. L. Gao, Y. Hoi, D. D. Swartz, J. Kolega, A. Siddiqui, H. Meng (2008) Nascent aneurysm formation at basilar terminus induced by hemodynamics. Stroke 39:2085-2090.
11. E. Metaxa, H. Meng, S. Kuluvala, M. Szymanski, R. Paluch, J. Kolega. (2008) Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow. Amer. J. Physiol., Heart Circ Physiol 295:736-742.
12. M. P. Szymanski, E. Metaxa, H. Meng, J. Kolega. (2008) Endothelial cell layer subjected to impinging flow mimicking the apex of an arterial bifurcation. Ann. Biomed. Eng. 36:1681-1689.
13. H. Meng, Z. J. Wang, Y. Hoi, L. Gao, E. Metaxa, D. D. Swartz, J.  Kolega. (2007) Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 38:1924-1931.