Dr. Arumugam Radhakrishnan Jayakumar

University of Miami, USA

Email: avrj_2000@yahoo.com

Qualifications

1998  Ph.D., University of Madras, India

1992  M.Phil., University of Madras, India

1991  M.Sc., Bharathidasan University, India

Publications(Selected)

1. G. Bai, K. V. Rama Rao, Ch. R. K. Murthy, K. S. Panickar, A. R. Jayakumar and Norenberg M. D (2001). Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. Journal of Neuroscience Research. 66, 981-991.
2. N. Shyamaladevi, A. R. Jayakumar, R. Sujatha, V. Paul and E. H. Subramanian (2002). Evidence that nitric oxide production increases gamma aminobutyric acid permeability of blood-brain barrier. Brain Research Bulletin. 57(2), 321-326.
3. K. S. Panickar, A. R. Jayakumar, and M. D. Norenberg (2002). Differential response of neural cells to trauma-induced free radical production in vitro. Neurochemical Research.  27(1), 161-166.
4. A.R. Jayakumar, K. S. Panickar and M. D. Norenberg (2002). Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. Journal of Neurochemistry.  83(5), 1226-34.
5. K. V. Rama Rao, A. R. Jayakumar, and M. D. Norenberg (2003). Induction of the mitochondrial permeability transition in cultured astrocytes by Glutamine. Neurochemistry International, 1355, 1-7.
6. K. V. Rama Rao, A. R. Jayakumar, and M. D. Norenberg (2003). Ammonia neurotoxicity: Role of the mitochondrial permeability transition. Metabolic Brain Disease. 18(2), 113-127.
7. A.R. Jayakumar, K. V. Rama Rao, A. Schousboe and M. D. Norenberg (2004). Glutamine-induced free radical production in cultured astrocytes. Glia. 46, 296-301.
8. M. D. Norenberg, A. R. Jayakumar, and K. V. Rama Rao (2004). Oxidative stress in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease. 19(3/4), 309-325.
9. M. D. Norenberg, K. V. Rama Rao and A. R. Jayakumar (2004). Ammonia neurotoxicity and the mitochondrial permeability transition. Journal of Bioenergy and Biomembrane. 36(4), 303-307.
10. A.R. Jayakumar, K. V. Rama Rao, P. Kalaiselvi and M. D. Norenberg (2004). Combined effects of ammonia and manganese on astrocytes in culture. Neurochemical Research. 29(11), 2051-2056.
11. K. V. Rama Rao, A. R. Jayakumar, and M. D. Norenberg (2005). Differential response to glutamine on cultured neurons and astrocytes. Journal of Neuroscience Research. 79(1-2), 193-9.
12. R. Ramakrishnan, K. Prabhakaran, A. R. Jayakumar, P. Gunasekaran, R. Sheeladevi, and N. Suthanthirarajan. (2005). Changes in indolamines level correlated with CaMKII expression in rat brain during hyperglycemia and acidosis. Journal of Neuroscience Research. 80(4), 518-528.
13. M. D. Norenberg, K. V. Rama Rao and A. R. Jayakumar (2005). Mechanisms of ammonia-induced astrocyte swelling. Metabolic Brain Disease. 20(4), 303-318.
14. K. V. Rama Rao, A. R. Jayakumar and M. D. Norenberg (2005). Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes. Neurochemistry International. 47(1-2), 31-38.
15. R. Ramakrishnan, D. Kempuraj, K. Prabhakaran, A. R. Jayakumar, R. Sheeladevi, N.  Suthanthirarajan (2005). A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete areas of rat brain. Life Sciences. 77(15), 1825-1835.
16. K. V. Rama Rao, K. S. Panickar, A. R. Jayakumar and M. D. Norenberg (2005). Astrocytes protect neurons from ammonia toxicity.  Neurochemical Research. 30(10), 1311-1318.
17. A.R. Jayakumar, K. V. RamaRao and M. D. Norenberg (2006). Role of glutamine in the mechanism of ammonia-induced astrocyte swelling. Neurochemistry International. 48(6-7), 623-628.
18. R. Jayakumar, K. S. Panickar, Murthy Ch R and M. D. Norenberg (2006). Oxidative stress and MAPK phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. Journal of Neuroscience  26(18), 4774-4784.
19. V. B. Pichili, K. V. Rama Rao, A. R. Jayakumar and M. D. Norenberg (2007). Inhibition of glutamine transport into mitochondria protects astrocytes from ammonia toxicity. Glia.  55(8), 801-809.
20. M. D. Norenberg, A. R. Jayakumar, K. V. Rama Rao and K. S. Panickar (2007). New concepts in the mechanism of ammonia-induced astrocyte swelling. Metabolic Brain Disease. 22(3-4), 219-234.
21. K. S. Panickar, A. R. Jayakumar, K. V. Rama Rao and M. D. Norenberg (2007). Downregulation of the 18 kDA translocator protein (TSPO): Effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes. Glia. 55(16), 1720-1727.
22. A.R. Jayakumar, K.V. Rama Rao, K. S. Panickar, M. Moriyama, P. V. B. Reddy and M. D. Norenberg (2008). Trauma-induced cell swelling in cultured astrocytes. Journal of Neuropathology and Experimental Neurology. 67(5), 417-427.
23. P. Sinke, A.R. Jayakumar, K. S. Panickar, M. Moriyama, P. V. B. Reddy and M. D. B in the mechanism of ammonia-induced astrocyte swellingkNorenberg (2008). NF- in culture. Journal of Neurochemistry. 106(6), 2302-2311.
24. R. Jayakumar, M. Liu, M. Moriyama, R. Ramakrishnan, P. V. B. Reddy, M. D. Norenberg (2008). Na-K-2Cl Cotransporter-1 in the Mechanism of Ammonia-Induced Astrocyte Swelling. Journal of Biological Chemistry. 283(49),33874-33882.
25. M. D. Norenberg, K. V. Rama Rao, A. R. Jayakumar (2009). Pathways and signaling in ammonia neurotoxicity. Metabolic Brain Disease. 24(1), 103-117.
26. A.R. Jayakumar, K. V. Rama Rao, X.Y.  Tong, M.D. Norenberg (2009). Calcium in the mechanism of cell swelling in cultured astrocytes. Journal of Neurochemistry. 109(s1), 252-257.
27. K. S. Panickar, A. R. Jayakumar; K. V. Rama Rao, M. D. Norenberg (2009). Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake. Neurochemistry International. 55(1-3), 98-105.
28. A.R. Jayakumar, M. D. Norenberg (2010). Na-K-2Cl Cotransporter-1 in the Mechanism of Astrocyte Swelling. Metabolic Brain Disease. 25(1):31-38.
29. M. Moriyama; A. R. Jayakumar; X. Y. Tong, M. D. Norenberg (2010). Role of MAPKs in the mechanism of oxidant-induced cell swelling in cultured astrocytes. Journal of Neuroscience Research. 88(11):2450-2458.
30. K.V. Rama Rao, A. R. Jayakumar, V. B. Pichili, X. Y. Tong, K.M. Curtis, M. D. Norenberg (2010) Manganese Increases Aquaporin-4 in Cultured Astrocytes: Role of Oxidative/Nitrosative Stress and Mitogen-Activated Protein Kinases. Glia. 58:1490-1499.
31. K. V. Rama Rao, A. R. Jayakumar, X. Y. Tong, K. M. Curtis, M. D. Norenberg (2010) Brain aquaporin-4 in experimental acute liver failure.  Journal of Neuropathology and Experimental Neurology. 69(9):869-879.
32. K. V. Rama Rao, A. R. Jayakumar, X. Y. Tong, V. M. Alvarez, M. D. Norenberg (2010) Synergism by Ammonia and Cytokines on Astrocyte Swelling in Culture. Journal of Neuroinflammation. 7:66.
33. A.R. Jayakumar, V. Valdes, M. D. Norenberg (2011). The Na-K-Cl cotransporter-1 in the brain edema of acute liver failure. Journal of Hepatology. 54(2):272-278.
34. R. B inkJayakumar, J. R. Bethea, X.Y. Tong, M. D. Norenberg (2011) NF- ammonia-induced astrocyte swelling and in brain edema in acute liver failure: studies in transgenic mice. Neurobiology of Disease 41(2):498-507.
35. R. Jayakumar, K. S. Panickar, K.M Kurtis, M. D. Norenberg (2011). Na-K-2Cl Cotransporter-1 in the mechanism of trauma-induced astrocyte swelling. Journal of Neurochemistry 117(3):437-448.