Dr. Xianxin Hua

University of Pennsylvania, USA

Email: huax@mail.med.upenn.edu

Qualifications

1995 Ph.D., University of Texas Southwestern Medical Center, USA

1986 M.S., Hubei Medical College, China

1983 M.D., Hubei Medical College, China

Publications (Selected)

1. Wu, T., Zhang, X., Huang, X., Yang, Y. and Hua, X. Regulation of cyclin B2 expression and G2/M transition by menin. Journal of Biological Chemistry. Jun 1,; 85(24):18291-300. 2010.
2. Zi-Jie Feng, Shu-Bin Gao, Yuan Wu, Xiang-Fan Xu, Xianxin Hua, Guang-Hui Jin. Lung cancer cell migration is regulated via repressing growth factor PTN/ RPTP β/ζ signaling by menin. Oncogene. 2010, 9;28(46):4095-104.
3. Aggarwal P, Pontano Vaites L, Kim JK, Mellert H, Gurang B, Hua X, Nakagawa H, Herlyn M, Rustgi AK, McMahon SB and Diehl JA. Nuclear Cyclin D1/CDK4 Kinase Regulates Cul4 Expression and Tumorigenesis via Activation of the PRMT5 Methyltransferase. Cancer Cell. 2010. Cancer Cell. Oct 19; 18(4):329-40. 2010.
4. Yang, Y., Gurung, B., Wu, T., Wang, H., Stoffers, D. A. and Hua, X. Reversal of pre-existing hyperglycemia in diabetic mice by acute deletion of Men1. Proc Natl Acad Sci U S A. Nov 23; 107(47):20358-63. 2010.
5. Maillard I, Chen YX, Friedman A, Yang Y, Tubbs AT, Shestova O, Pear WS, Hua, X. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood. Feb 19;113(8):1661-9. 2009.
6. J Yan, Y Yang, H Zhang, C King, HM Kan, Y Cai, CX Yuan, GS Bloom, and X Hua. Menin Interacts with IQGAP1 to Enhance Intercellular Adhesion of beta Cells. Oncogene.Feb 19;28(7):973-82. 2009.
7. Gao, SB., Feng, ZJ., Xu, B., Wu, Y., Yin, P.,  Yang, Y., Hua, X., Jin, GH. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 19;28(46):4095-104.2009.
8. Manabu Hashimoto, Satoru Kyo, Xianxin Hua, Hidetoshi Tahara, Miki Nakajima, Masahiro Takakura, Junko Sakaguchi, Yoshiko Maida, Mitsuhiro Nakamura, Tomomi Ikoma, Yasunari Mizumoto and Masako Inoue. Role of menin in the regulation of telomerase activity in normal and cancer cells. Int J Oncol. 33(2):333-40. 2008.
9. Gao, S, Hua, X and Jin G. Menin Regulates Endocrine Diseases by Controlling Histone Modification and Gene Transcription. Ann of Endocrinology (France). Nov;69(5):426-32. Epub 2008 Aug 26. Review. 2008.
10. Wu, X. and Hua, X.  Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and Perspective. Current Molecular Medicine. Dec; 8(8):805-15. Review. 2008.
11. Yang, Y. and Hua, X.  In search of the function of tumor suppressor menin. Molecular and  Cellular Endocrinology. Feb;265-266:34-41. Epub 2007 Jan 11. 2007.
12. Wu XJ and Hua X. Targeting ROS: Selective Killing of Cancer Cells by a Cruciferous Vegetable Derived Pro-Oxidant Compound. Cancer Biol Ther. May; 6(5):646-7. Epub 2007 Mar 1. 2007.
13. Ping La, Yuqing Yang, Satyajit K. Karnik, Albert C. Silva, Robert W. Schnepp, Seung K. Kim and Hua X.. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem. Oct 26; 282(43):31332-40. 2007.
14. Claudia D. Andl, Brenton B. Fargnoli, Takaomi Okawa , Mark Bowser, Munenori Takaoka, Hiroshi Nakagawa, Andres Klein-Szanto, Xianxin Hua, Meenhard Herlyn and Anil K. Rustgi.  Coordinated functions of E-cadherin and TGF receptor II in vitro and in vivo. Cancer Research. Oct 15; 66(20):9897-85. 2006.
15. Jizhou Yan, Angela Desmond, Albert Silva, Ya-Xiong Chen, Yuqing Yang, Haoren Wang, and Hua, X. Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. PLoS ONE. Dec 20;1:e47. 2006.