Biography

Prof. Bing-wen Soong

National Yang-Ming University, Chinese Taipei


Email: bwsoong@vghtpe.gov.tw


Qualifications

1998 Professor of Neurology and Neurosciences, National Yang-Ming University, Taiwan


Publications (Selected)

  1. Hu HH, Teng MM, Hsu LC, Wong WJ, Wang LM, Luk YO, Chern CM, Soong BW, Sheng WY. A Pilot Study of a New Thrombolytic Agent for Acute Ischemic Stroke in Taiwan within A Five-Hour Window. Stroke 2006; 37: 918-9.
  2. Lee YC, Yang AH, Liu HC, Wong WJ, Lu YC, Chang MH, Soong BW.y. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy due to two novel mutations in the NOTCH3 gene. J Neurol Sci 2006; 246: 111-5.
  3. Soong BW.y, Nicholas Di Prosperos, Kenneth Fischbeck. Current Progress and Potential Therapeutic Strategies of Dominant Hereditary Ataxias. Curr Trends Neurol, 2006; 2: 87-103.
  4. Lee YC, Lu YC, Chang MH, Soong BW.y Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patient with adult-onset ataxia on Taiwan. J Neurol Sci 2007; 254: 65-8.
  5. Chiang MC, Chen HM, Lee YH, Chang HH, Wu YC, Soong BW, Chen CM, Wu YR, Liu CS, Niu DM, Wu JY, Chen YC, and Chern YJ. Dysregulation of C/EBPα by mutant Huntingtin causes the urea cycle deficiency in Huntington’s disease. Hum Mol Genet 2007; 16: 483-98.
  6. Wang PS, Liu RS, Yang BH, Soong BW.y. Topographic brain mapping of the international cooperative ataxia rating scale: A positron emission tomography study. J Neurology 2007; 254: 722-8.
  7. Wang PS, Liu RS, Yang BH, Soong BBW.y. Regional patterns of cerebral glucose metabolism in spinocerebellar ataxia type 2, 3 and 6: a voxel-based FDG-positron emission tomography analysis. J Neurol 2007; 254: 838-45.
  8. Liu YT, Lin KH, Soong BW, Liao KK, Lin KP. A novelABCD1 gene mutation in a Chinese-Taiwanese patient with adrenomyeloneuropathy. Pediatr Neurol 2007; 5: 348-50.
  9. Wang KC, Wang V, Sun MC, Chiueh TI, Soong BW, Shan DE. Polymorphism distribution of prion protein codon 117, 129 and 171 inTaiwan. Eur J Epidemiol 2007; 22: 257-61.
  10. Chen CM, Wu YR, Cheng ML, Liu JL, Lee YM, Lee PW, Soong BW, Chiu DT. Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients. Biochem Biophys Res Commun 2007; 359: 335-40.
  11. Chung CP, Hsu HY, Chao AC, Sheng WY, Soong BW, Hu HH. Transient global amnesia: cerebral venous outflow impairment— insight from the abnormal flow patterns of the internal jugular vein. Ultrasound in Med Biol. 2007; 33: 1727-35.
  12. Lai TH, Soong BW, Chen JT, Chen YY, Lai KL, Wu JA, Liao KK. Multimodal Evoked Potentials of Kennedy's Disease. Can J Neurol Sci. 2007; 34: 328-32.
  13. Martins S, Calafell F, Gaspar C, Wong VCN, Silveira I, Nicholson GA, Brunt ER, Tranebjaerg L, Stevanin G, Hsieh ML, Soong BW, Loureiro L, Du¨ rr A, Tsuji S, Watanabe M, Jardim LB, Giunti P, Riess O, Ranum LPW, Brice A, Rouleau GA, Coutinho P, Amorim A, Sequeiros J.Asian origin for the worldwide spread mutational event in Machado-Joseph disease. Arch Neurol 2007; 64: 1502-8.
  14. Hung CI, Wang PS, Soong BW, Teng S, Hsieh JC, Wu YT. Blind source separation of concurrent disease-related patterns from EEG in Creutzfeldt-Jakob disease for assisting early diagnosis. Ann Biomed Eng 2007; 35: 2168-79.
  15. Soong BW, Paulson H. Spinocerebellar ataxias: an update. Curr Op Neurol 2007; 20: 438-46.
  16. Lee YC, Yu CT, Lin KP, Chang MH, Hsu SL, Liu YF, Soong BW.y MPZ Mutation G123S characterization: evidence for a complex pathogenesis in CMT disease. Neurology 2008; 70: 273-7.
  17. Liu CS, Cheng WL, Kuo SJ, Li JY, Soong BW, Wei YH. Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases. J Neurol Sci 2008; 264: 18-21.
  18. Wang PS, Wu YT, Hung CI, Kwan SY, Teng S, Soong BW.y Early detection of periodic sharp wave complexes on EEG by independent component analysis in patients with Creutzfeldt-Jakob disease. J Clin Neurophysiol 2008;25:25-31.
  19. Craig K, Takiyama Y, Soong BW, Jardim LB, Saraiva-Pereira ML, Lythgow K, Morino H, Maruyama H, Kawakami H, Chinnery PF. Pathogenic expansions of the SCA6 locus are associated with a common CACNA1A haplotype across the globe: founder effect or predisposing chromosome? Eur J Hum Genet 2008; 16: 841-7.
  20. Wang PS, Soong BW.y. Early detection of periodic sharp wave complexes on EEG by independent component analysis in patients with Creutzfeldt-Jakob disease (Commentary). J Clin Neurophysiol 2008; 25: 239-40.
  21. Lu CF, Wang PS, Chou YC, Li HC, Soong BW, Wu YT. Segmentation of diffusion-weighted brain images using expectation maximization algorithm initialized by hierarchical clustering. Conf Proc IEEE Eng Med Biol Soc. 2008; 1: 5502-5.
  22. Wang V, Chuang TC, Soong BW, Shan DE, Kao MC. Octarepeat changes of prion protein in Parkinson's disease. Parkinsonism & Relat Disord 2009; 15: 53–8.
  23. Wu YR, Chen IC, Soong BW, Kao SH, Lee GC, Huang SY, Fung HC, Lee-Chen GJ, Chen CM. SCA8 repeat expansion: large CTA/CTG repeat alleles in neurological disorders and functional implications. Hum Genet 2009; 125: 437-44.
  24. Lee YC, Liu CS, Chang LB, Wang PS, Lu YC, Chang MH, Soong BW. y The “Hot cross bun” sign in the patients with spinocerebellar ataxia. Euro J Neurol, 2009;16:513-6.
  25. Lee YC, Liu CS, Chang MH, Lin KP, Fuh JL, Lu YC, Liu YF, Soong BW. y Population-specific spectrum of NOTCH3 mutations and MRI features of CADASIL in Chinese. J Neurol, 2009;256:249-55.
  26. Lee YC, Yang AH, Soong BW.y The remarkably variable expressivity of CADASIL: report of a minimally symptomatic gentleman at an advanced age. J Neurol 2009; 256: 1026-7.
  27. Wang ZY, Soong BW, Wang PS., Jao CW, Shyu KK, Wu YT. Quantifying brain atrophy of Multiple System Atrophy of the Cerebellar type (MSA-C) using fractal dimension analysis. IFMBE Proceedings 2009; 25: 940-943.
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