Author(s)

Takafumi Tezuka^1*, Atsunori Higashino¹, Mitsuo Akiba², Takashi Nakamura²

¹Graduate School of Information Science, Nagoya University, Nagoya, Japan.
²Asai Germanium Research Institute Co., Ltd., Hakodate, Japan.

Assays of stress enzymes related to active oxygen species were performed by using an in vitro preparation from the liver of a monkey (Japanese Macaque). Ge-132, an organic germanium compound, viz. poly-trans-[(2-carboxyethyl) germasesquioxane] [(GeCH₂CH₂COOH)₂O₃]_n, suppressed the activities of NADH-dependent oxidase and NADPH-dependent oxidase [NAD(P)H-OD] and xanthine oxidase (XOD) as superoxide-forming enzymes, while promoting the activities of superoxide dismutase (SOD) as a superoxide-scavenging enzyme and catalase (CAT) as an enzyme responsible for degradation of hydrogen peroxide (H₂O₂). The evidence suggests that the levels of active oxygen species such as and H₂O₂ would be reduced by Ge-132. The possible connection between Ge-132 and activities of stress enzymes is discussed on the basis of these results.

Active Oxygen Species, Stress Enzymes [CAT, NAD(P)H-OD, SOD, XOD], Ge-132 [(GeCH₂CH₂COOH)₂O₃]_n, Monkey Liver

Tezuka, T. , Higashino, A. , Akiba, M. and Nakamura, T. (2017) Organogermanium (Ge-132) Suppresses Activities of Stress Enzymes Responsible for Active Oxygen Species in Monkey Liver Preparation. Advances in Enzyme Research, 5, 13-23. doi: 10.4236/aer.2017.52002.