Mitochondrial Activity and Cell Damage after Application of Acmella oleracea Leaf Extract - American Journal of Plant Sciences

AJPS > Vol.7 No.17, December 2016

Mitochondrial Activity and Cell Damage after Application of Acmella oleracea Leaf Extract ()

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Download as PDF (Size: 1037KB) PP. 2498-2504

DOI: 10.4236/ajps.2016.717217 1,460 Downloads 2,305 Views Citations

Author(s)

Carlos Augusto Priante da Silva^1*, Cristina Pacheco Soares¹, Walderez Moreira Joaquim², Renato Farina Menegon³

Affiliation(s)

¹Instituto de Pesquisa e Desenvolvimento (IP & D), Laboratório de Dinamica de Compartimentos Celulares, Universidade do Vale do Paraíba (Univap), Sao José dos Campos, Brazil.
²Instituto de Pesquisa e Desenvolvimento (IP & D), Laboratório de Fotoacústica Aplicada a Sistemas Biológicos, Universidade do Vale do Paraíba (Univap), Sao José dos Campos, Brazil.
³Laboratório de Insumos Naturais e Sintéticos, Universidade Federal de Sao Paulo (Unifesp), Diadema, Brazil.

ABSTRACT

Acmella oleracea is a plant species belonging to the Asteraceae family, native to the Amazon that has broad therapeutic and culinary use. Several secondary metabolites and your bioactive component spilanthol have been associated with its medicinal effects. This study aims to evaluate the leaf extract of A. oleracea for therapeutic purposes. When applied to both cell cultures HEp-2 neoplastic cells and L929 fibroblast cells, the increasing extract concentrations yielded a significant reduction in cell viability using ANOVA test with Significance of P ≤ 0.05 (*), Very Significant P ≤ 0.01 (***) and Extremely Significant P ≤ 0.001 (****), causing visible damage to cytoskeleton actin filaments. The cytotoxicity of the A. oleracea leaf extract may be associated with other components, including flavonoids. Thus, A. oleracea has a great cytotoxic activity on tumoral cells and can be considered for future antitumor therapy. However, because of its toxicity to non-tumoral cells, it is essential to evaluate the efficacy of each extract sub-fraction compound, alerting the population for the traditional use of the plant that can cause damage for the consumer.

KEYWORDS

Acmella oleracea, Jambú, Cytoskeleton, Nuclei, Cytotoxicity

Share and Cite:

da Silva, C. , Soares, C. , Joaquim, W. and Menegon, R. (2016) Mitochondrial Activity and Cell Damage after Application of Acmella oleracea Leaf Extract. American Journal of Plant Sciences, 7, 2498-2504. doi: 10.4236/ajps.2016.717217.

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