Spatial structure of beta-amyloid Aβ_1-40 in complex with a biological membrane model

Konstantin S. Usachev, Andrey V. Filippov, Oleg N. Antzutkin, Vladimir V. Klochkov

Kazan Federal University, Kazan, Russia.
Lule? University of Technology, Lule?, Sweden.

DOI: 10.4236/aad.2012.13004                

Abstract

The spatial structure of beta-amyloid Aβ_1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by ¹H-¹H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.

Keywords

¹H NMR; Two-Dimensional NMR (TOCSY, NOESY) Spectroscopy; Alzheimer’s Disease; Beta-Amyloid; Oligopeptides; Micelle

Conflicts of Interest

The authors declare no conflicts of interest.

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