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Role of HLA-A, HLA- B, HLA-DRB1 and HLADQB1 Alleles in HIV-1 Patients with Pulmonary Tuberculosis Co-Infection from Western India

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DOI: 10.4236/wja.2011.14019    5,181 Downloads   7,812 Views   Citations

ABSTRACT

We attempted to study the role of HLA HLA-A, B, DRB1 and DQB1 in HIV-1 patient’s co infected with pulmonary tuberculosis (PTB). A total of 102 HIV-1 + patients co-infected with pulmonary tuberculosis and 200 healthy controls were included in HLA analysis. HLA-A*, HLA-B* HLA-DRB1* and DQB1* typing was done molecularly by PCR- SSOP (Polymerase Chain reaction-Sequence Specific Oligonucleotide Probing) method using kit (Dynal Kit – Invitrogen). The frequencies of the HLA-A, B HLA-DRB,1 and DQB1 alleles were determined using standard software. The HLA alleles identified among HIV + ve/PTB + ve co-infected patients as compared with healthy controls showed a significantly increased frequency of HLA-B*08:01:01 in HIV + ve/PTB + ve co-infected patients when compared with healthy controls (p = 0.011, OR 3.335, 95% CI 1.35-8.18), Likewise HLA-DQB1*03:01:03 was significantly increased in HIV + ve/PTB + ve co-infected patients as against healthy controls (p < 0.0001, OR 107.5, 95% CI 6.195 - 1865.3). Similarly HLA-DQB*06:01:02 allele frequency was observed in HIV + ve/PTB + ve co-infected patients as against healthy controls (p = 0.003, OR 4.808, 95% CI 1.72-13.39), HLA-DQB1*03:01:01 (p = 0.045, OR 0.219, 95% CI 0.051 - 0.940), HLA-DQB1*06:01:01:01 (p = 0.012, OR 0.334, 95% CI 0.145 - 0.770), alleles in HIV + ve/PTB + ve co-infected patients when compared with healthy controls. We can be concluded that different HLA alleles may render susceptibility or protection to in different ethnic population.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

U. Shankarkumar and A. Shankarkumar, "Role of HLA-A, HLA- B, HLA-DRB1 and HLADQB1 Alleles in HIV-1 Patients with Pulmonary Tuberculosis Co-Infection from Western India," World Journal of AIDS, Vol. 1 No. 4, 2011, pp. 136-138. doi: 10.4236/wja.2011.14019.

References

[1] Ministry of Health and Family Welfare, “National AIDS Control Organization (NACO) Report 2008,” Government of India News Letter, 2008.
[2] V. Vijayalakshmi, S. R. Shilpa, B. Anuradha, et al., “Role of HLA-B51 and HLA-B52 in Susceptibility to Pulmonary Tuberculosis,” Infection, Genetics and Evolution, Vol. 6, No. 6, 2006, pp. 436-439. doi:10.1016/j.meegid.2006.02.002
[3] M. Carrington and S. J. O’Brien, “The Influence of HLA Genotype on AIDS,” Annual Review of Medicine, Vol. 54, 2003, pp. 535-551. doi:10.1146/annurev.med.54.101601.152346
[4] A. P. Achord, R. E. Lewis, M. N. Brackin, et al., “HIV-1 Disease Association with HLA-DQ Antigen in Africans Americans and Caucasians,” Pathobiology, Vol. 64, No. 4, 1996, pp. 204-208. doi:10.1159/000164049
[5] N. Odum, J. Georgsen, L. Fugger, et al., “HLA-DP Antigens in HIV Infected Individuals,” Disease Markers, Vol. 8, No. 3, 1990, pp. 113-116.
[6] J. Wang, C. Song and S. Wang, “Association of HLA- DRB1 Genes with Pulmonary Tuberculosis,” Chinese Journal of Tuberculosis and Respiratory Disease, Vol. 24, No. 5, 2001, pp. 302-305.
[7] P. Selvaraj, S. Ragavan, S. Swaminathan, et al., “HLA- DQB-1 and HLA-DPB-1 Allele Profile in HIV Patients Infected with or without Pulmonary Tuberculosis of South India,” Infection, Genetics and Evolution, Vol. 8, No. 5, 2008, pp. 664-671. doi:10.1016/j.meegid.2008.06.005
[8] M. Ravikumar, V. Dheenadhayalan, K. Rajaram, et al., “Associations of HLA-DRB1, DQB1 and DPB1 Alleles with Pulmonary Tuberculosis in South India,” Tubercle and Lung Disease, Vol. 79, No. 5, 1999, pp. 309-317. doi:10.1054/tuld.1999.0213
[9] A. Vyakarnam, D. Sidebottom, S. Murud, et al., “Possession of Human Leucocytes Antigen DQ6 Alleles and the Rate of CD4 T-Cell Decline in Human Immunodeficiency Virus-1 Infection,” Immunology, Vol. 112, No. 1, 2004, pp. 136-142. doi:10.1111/j.1365-2567.2004.01848.x
[10] A. Dubaniewicz, G. Moszhowska and Z. Szczerkowska, “Frequency of DRB1-DQB1 Two Locus Haplotypes in Tuberculosis: Preliminary Report,” Tuberculosis, Vol. 85, No. 4, 2005, pp. 259-267. doi:10.1016/j.tube.2004.12.003
[11] J. F. Fernando de castro, V. R. Maria de Lourdes, S. D. Neifi Hassam, et al., “HLA Profile in Patients with AIDS and Tuberculosis,” The Brazilian Journal of Infectious Diseases, Vol. 12, No. 4, 2008, pp. 278-280.
[12] M. Patricia, M. Karina, S. Adrian, et al., “Association of HLA-DQ and HLA-DR Alleles with Susceptibility or Resistance to HIV-1 Infection among Population of Chaco Province, Argentina,” Medicina, Vol. 62, No. 3, 2002, pp. 245-248.

  
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