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Visualization of protein structure relationships using constrained twin kernel embedding

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DOI: 10.4236/jbise.2008.12022    3,980 Downloads   7,401 Views   Citations

ABSTRACT

In this paper, a recently proposed dimensional-ity reduction method called Twin Kernel Em-bedding (TKE) [10] is applied in 2-dimensional visualization of protein structure relationships. By matching the similarity measures of the input and the embedding spaces expressed by their respective kernels, TKE ensures that both local and global proximity information are preserved simultaneously. Experiments conducted on a subset of the Structural Classification Of Pro-tein (SCOP) database confirmed the effective-ness of TKE in preserving the original relation-ships among protein structures in the lower di-mensional embedding according to their simi-larities. This result is expected to benefit sub-sequent analyses of protein structures and their functions.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Guo, Y. , Gao, J. , Kwan, P. and Hou, X. (2008) Visualization of protein structure relationships using constrained twin kernel embedding. Journal of Biomedical Science and Engineering, 1, 133-140. doi: 10.4236/jbise.2008.12022.

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