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Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD

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DOI: 10.4236/ojpsych.2014.42019    3,160 Downloads   4,301 Views  

ABSTRACT

The objective of this study was to examine whether stimulants impact pubertal development in adolescent Attention Deficit Hyperactivity Disorder (ADHD), an understudied subject. Pubertal staging data were collected during a 2-year open study of extended release methylphenidate in adolescents (N = 111) with ADHD. Tanner stages were compared to national estimates. The sample was primarily male, Caucasian, and a mean age of 14.8 years at baseline. The baseline Tanner stage for 70% of subjects was consistent with chronological age. For the majority of subjects who reached 12 - 20 months (N = 25) or 24 months (N = 21) endpoints, the Tanner stage at respective endpoints was consistent with age. We found that progression in Tanner stage was not associated with OROS MPH duration or dose (p > 0.10). Long-term treatment with extended release methylphenidate did not appear to adversely impact pubertal development in this sample of adolescents with ADHD.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Hammerness, P. , Geller, D. , Joshi, G. , Georgiopoulos, A. , Doyle, R. , Spencer, T. , Petty, C. , Mahoney, L. and Biederman, J. (2014) Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD. Open Journal of Psychiatry, 4, 147-152. doi: 10.4236/ojpsych.2014.42019.

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