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The Prognostic Importance of EGFR and COX-2 Expression in Cervix Cancer Stages IIb-IVa

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DOI: 10.4236/jct.2011.21002    5,167 Downloads   10,621 Views   Citations

ABSTRACT

Objectives. Locally advanced cervix cancer represents a therapeutic challenge with a delicate balance between effect and toxicity. Consequently, there is an obvious need for new prognostic parameters with a perspective of a more individualized treatment. The aim of the present study was to evaluate the possible prognostic importance of epidermal growth factor receptor and cyclooxygenase-2 expression in locally advanced cervix cancer. Methods. The study included 91 patients with cervix cancer, FIGO stages IIb-IVa, and were treated with curative intent according to the Nordic Cervix Cancer protocol (NOCECA). The median observation time was 7 years. Epidermal growth factor receptor and cyclooxygenase-2 expression was evaluated by immunohistochemistry using commercially available antibodies. The tumor marker expression was evaluated according to a semi-quantitative scoring system with a positive score when more than 10% of the tumor cells were moderately or strongly stained. Results. Epidermal growth factor receptor and cyclooxygenase-2 over-expression was found in 22% and 18% of the patients, respectively. The survival differed according to epidermal growth factor receptor and cyclooxygenase-2 over-expression as calculated by Kaplan-Meier plots and log-rank test (p = 0.0002 and p = 0.0084 respectively). A multivariate Cox Regression analysis identified each tumor marker as an independent prognostic factor. Conclusion. The results clearly indicate epidermal growth factor receptor and cyclooxygenase-2 hold important prognostic information, markedly appearing with a long-term observation. We found that both parameters were independent prognostic factors, and to further clarify this matter our retrospective analysis should be confirmed in a prospective study with more patients.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

P. Adimi, K. Steffensen, D. Schledermann, E. Rasmussen and A. Jakobsen, "The Prognostic Importance of EGFR and COX-2 Expression in Cervix Cancer Stages IIb-IVa," Journal of Cancer Therapy, Vol. 2 No. 1, 2011, pp. 9-15. doi: 10.4236/jct.2011.21002.

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