Share This Article:

A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease

Abstract Full-Text HTML XML Download Download as PDF (Size:275KB) PP. 62-69
DOI: 10.4236/alc.2013.23008    5,313 Downloads   10,686 Views  

ABSTRACT

Chronic obstructive pulmonary disease is an inflammatory condition with increased risk of lung cancer. We hypothesized that curcumin/ bioperine (CB), which has anti-inflammatory effects, may reduce cytological abnormalities in the sputum of patients with COPD. We conducted a 3-month, three-to-one randomized, doubleblind, pilot trial of escalating doses of CB in patients with moderate or worse COPD who were capable of producing sputum. The primary efficacy endpoint was changed in sputum cytology. We also explored changes in fluorescence in situ hybridization (FISH). We obtained sputum samples for cytology and chromosome abnormalities at baseline and each monthly follow-up visit. We enrolled 57 participants, with 35 completing the study. The participants’ mean age (standard deviation [SD]) was 66.6 (8.2) years, and they were mainly male (91.2%), with an average of 63.8 pack-years of smoking history. Also, 42.1% of participants were active smokers and the mean (SD) FEV1 was 37% (13%). At baseline, 13 subjects had moderate or worse dysplasia (22.8%). Subjects with moderate to severe sputum dysplasia had more chromosome abnormalities in epithelial cells and neutrophils, as measured by deletion and aneuploidy in 10q22.3. The changes in sputum cytology and chromosome abnormalities did not differ between the active and placebo arms. CB was well tolerated at the bid doses of 1, 1.5, and 2 gm of curcumin and 5 mg of bioperine, with minor side effects related to the gastrointestinal tract. In this short pilot trial, CB compared to placebo did not alter cytological and chromosomal abnormalities seen in sputum of patients with COPD.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sharafkhaneh, A. , Lee, J. , Liu, D. , Katz, R. , Caraway, N. , Acosta, C. , Wistuba, I. , Aggarwal, B. , Dickey, B. , Moghaddam, S. , Hanania, N. , Newman, R. , Abdel-Monem, H. , Nguyen, N. , Farhangfar, C. , Hong, W. and Kurie, J. (2013) A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease. Advances in Lung Cancer, 2, 62-69. doi: 10.4236/alc.2013.23008.

References

[1] Rabe, K.F., Hurd, S., Anzueto, A., et al. (2007) Global strategy for the diagnosis, management, and prevention of COPD—2006 update. American Journal of Respiratory and Critical Care Medicine, 176, 532-555.
[2] Hogg, J.C., Chu, F., Utokaparch, S., et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. The New England Journal of Medicine, 350, 2645-2653. doi:10.1056/NEJMoa032158
[3] Hogg, J.C., Macklem, P.T. and Thurlbeck, W.M. (1968) Site and nature of airway obstruction in chronic obstructive lung disease. The New England Journal of Medicine, 278, 1355-1360. doi:10.1056/NEJM196806202782501
[4] Hogg, J.C., Chu, F.S., Tan, W.C., et al. (2007) Survival after lung volume reduction in chronic obstructive pulmonary disease: Insights from small airway pathology. American Journal of Respiratory and Critical Care Medicine, 176, 454-459. doi:10.1164/rccm.200612-1772OC
[5] Omenn, G.S., Goodman, G.E., Thornquist, M.D., et al. (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. The New England Journal of Medicine, 334, 1150-1155. doi:10.1056/NEJM199605023341802
[6] Moghaddam, S.J., Barta, P., Mirabolfathinejad, S.G., et al. (2009) Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis, 30, 1949-1956. doi:10.1093/carcin/bgp229
[7] Gupta, S.C., Kim, J.H., Prasad, S., et al. (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Reviews, 29, 405-435. doi:10.1007/s10555-010-9235-2
[8] Gupta, S.C., Kim, J.H., Kannappan, R., et al. (2011) Role of nuclear factor kappaB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Experimental Biology and Medicine (Maywood), 236, 658-671. doi:10.1258/ebm.2011.011028
[9] Goel, A. and Aggarwal, B.B. (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutrition and Cancer, 62, 919-930. doi:10.1080/01635581.2010.509835
[10] Sharma, R.A., McLelland, H.R., Hill, K.A., et al. (2001) Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clinical Cancer Research, 7, 1894-1900.
[11] Cruz-Correa, M., Shoskes, D.A., Sanchez, P., et al. (2006) Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clinical Gastroenterology and Hepatology, 4, 1035-1038. doi:10.1016/j.cgh.2006.03.020
[12] Shoba, G., Joy, D., Joseph, T., et al. (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64, 353-356. doi:10.1055/s-2006-957450
[13] (2005) ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. American Journal of Respiratory and Critical Care Medicine, 171, 912-930. doi:10.1164/rccm.200406-710ST
[14] (2002) ATS statement: Guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, 166, 111-117. doi:10.1164/ajrccm.166.1.at1102
[15] Katz, R.L., Zaidi, T.M., Fernandez, R.L., et al. (2008)Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancer. Modern Pathology, 21, 950-960. doi:10.1038/modpathol.2008.71

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.