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Efficacy of a triclosan/copolymer dentifrice and a toothbrush with tongue cleaner in the treatment of oral malodor: A monadic clinical trial

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DOI: 10.4236/ojst.2013.31012    2,724 Downloads   4,304 Views   Citations

ABSTRACT

Aim: Oral malodor (halitosis) is a widespread condition caused by oral bacteria, particularly sulfur compound-producing species. This study assessed the effect of a triclosan/copolymer-containing dentifrice and a novel toothbrush with attached tongue cleaner on oral malodor and on the bacteria colonizing the dorsal surface of the tongue. Materials and Methods: 14 adult subjects with oral malodor defined as organoleptic scores ≥ 3 (scale 0 - 5) and mouth air sulfur levels ≥ 250 ppb participated in this study. Subjects were examined at baseline and after 28 days use of the triclosan dentifrice and toothbrush/tongue cleaner for: 1) organoleptic assessment; 2) mouth air sulfur levels; 3) tongue coating; and, 4) dorsal tongue surface microorganisms. Total bacterial numbers were assayed by microscopy. Dot-blot hybridization was used to assess a panel of 20 oral bacteria. Results: After 28 days, all subjects had significantly reduced organoleptic scores and mouth air sulfur levels compared to baseline (p < 0.0001). There was >70% reduction in microbial numbers (p < 0.001) on the dorsal tongue and significant reductions in Enterococcus faecalis (p < 0.003), Neisseria sp. (p < 0.008), Peptostreptococcus micros (p < 0.0007), Prevotella melaninogenica (p < 0.02), Porphyromonas gingivalis (p < 0.0001), Solobacterium moorei (p < 0.04), and Streptococci sp. (p < 0.03). Conclusions: Oral malodor was successfully treated in all subjects following 28 days use of the triclosan/copolymer-containing dentifrice and toothbrush with a tongue cleaner as determined by significant reductions in clinical measures of halitosis and a corresponding reduction in microbiological measures including sulfur compound-producing oral bacteria.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sreenivasan, P. , Haraszthy, V. , Zambon, J. and DeVizio, W. (2013) Efficacy of a triclosan/copolymer dentifrice and a toothbrush with tongue cleaner in the treatment of oral malodor: A monadic clinical trial. Open Journal of Stomatology, 3, 63-69. doi: 10.4236/ojst.2013.31012.

References

[1] Scully, C. and Greenman, J. (2008) Halitosis (breath odor). Periodontology, 48, 66-75. doi:10.1111/j.1600-0757.2008.00266.x
[2] Roldán, S., Herrera, D. and Sanz, M. (2003) Biofilms and the tongue: Therapeutical approaches for the control of halitosis. Clinical Oral Investigations, 7, 189-197. doi:10.1007/s00784-003-0214-7
[3] Amiraian, D.E. and Sobal, J. (2009) Dating and eating: Beliefs about dating foods among university students. Appetite, 53, 226-232. doi:10.1016/j.appet.2009.06.012
[4] Rayman, S. and Almas, K. (2008) Halitosis among racially diverse populations: An update. International Journal of Dental Hygiene, 6, 2-7. doi:10.1111/j.1601-5037.2007.00274.x
[5] Quirynen, M., Dadamio, J., Van den Velde, S., De Smit, M., Dekeyser, C., Van Tornout, M. and Vandekerckhove, B. (2009) Characteristics of 2000 patients who visited a halitosis clinic. Journal of Clinical Periodontology, 36, 970-975. doi:10.1111/j.1600-051X.2009.01478.x
[6] Krespi, Y.P., Shrime, M.G. and Kacker, A. (2006) The relationship between oral malodor and volatile sulfur compound-producing bacteria. Otolaryngology-Head and Neck Surgery, 135, 671-676. doi:10.1016/j.otohns.2005.09.036
[7] Porter, S.R. and Scully, C. (2006) Oral malodour (halitosis). British Medical Journal, 333, 632-635. doi:10.1136/bmj.38954.631968.AE
[8] Bornstein, M.M., Kislig, K., Hoti, B.B., Seemann, R. and Lussi, A. (2009) Prevalence of halitosis in the population of the city of Bern, Switzerland: A study comparing selfreported and clinical data. European Journal of Oral Sciences, 117, 261-267. doi:10.1111/j.1600-0722.2009.00630.x
[9] Van den Broek, A.M., Feenstra, L. and de Baat, C. (2008) A review of the current literature on management of halitosis. Oral Diseases, 14, 30-39.
[10] Haraszthy, V.I., Zambon, J.J., Sreenivasan, P.K., Zambon, M.M., Gerber, D., Rego, R. and Parker, C. (2007) Identification of oral bacterial species associated with halitosis. Journal of the American Dental Association, 138, 1113-1120.
[11] Kazor, C.E., Mitchell, P.M., Lee, A.M., Stokes, L.N., Loesche, W.J., Dewhirst, F.E. and Paster, B.J. (2003) Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. Journal of Clinical Microbiology, 41, 558-563. doi:10.1128/JCM.41.2.558-563.2003
[12] Riggio, M.P., Lennon, A., Rolph, H.J., Hodge, P.J., Donaldson, A., Maxwell, A.J. and Bagg, J. (2008) Molecular identification of bacteria on the tongue dorsum of subjects with and without halitosis. Oral Diseases, 14, 251-258. doi:10.1111/j.1601-0825.2007.01371.x
[13] Blinkhorn, A., Bartold, P.M., Cullinan, M.P., Madden, T.E., Marshall, R.I., Raphael, S.L. and Seymour, G.J. (2009) Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease? British Dental Journal, 207, 117-125. doi:10.1038/sj.bdj.2009.669
[14] Gunsolley, J.C. (2006) A meta-analysis of six-month studies of antiplaque and antigingivitis agents. Journal of the American Dental Association, 137, 1649-1657.
[15] Fine, D.H., Furgang, D., Markowitz, K., Sreenivasan, P.K., Klimpel, K. and De Vizio, W. (2006) The anti microbial effect of a triclosan/copolymer dentifrice on oral microorganisms in vivo. Journal of the American Dental Association, 137, 1406-1413.
[16] Rosenberg, M. and McCulloch, C.A.G. (1992) Measurement of oral malodor: Current methods and future prospects. Journal of Periodontology, 63, 776-782. doi:10.1902/jop.1992.63.9.776
[17] Danser, M.M., Gómez, S.M. and Van der Weijden, G.A. (2003) Tongue coating and tongue brushing: A literature review. International Journal of Dental Hygiene, 1, 151-158. doi:10.1034/j.1601-5037.2003.00034.x
[18] Zambon, J.J., Reynolds, H.S., Dunford, R.G., DeVizio, W., Volpe, A.R., Berta, R., Tempro, J.P. and Bonta, Y. (1995) Microbial alterations in supragingival dental plaque in response to a triclosan-containing dentifrice. Oral Microbiology and Immunology, 10, 247-255. doi:10.1111/j.1399-302X.1995.tb00150.x
[19] Hatt, H. (2004) Molecular and cellular basis of human olfaction. Chemistry & Biodiversity, 1, 1857-1869. doi:10.1002/cbdv.200490142
[20] Vandekerckhove, B., Van den Velde, S., De Smit, M., Dadamio, J., Teughels, W., Van Tornout, M. and Quirynen, M. (2009) Clinical reliability of non-organoleptic oral malodour measurements. Journal of Clinical Periodontology, 36, 964-969.
[21] Furne, J., Majerus, G., Lenton, P., Springfield, J., Levitt, D.G. and Levitt, M.D. (2002) Comparison of volatile sulfur compound concentrations measured with a sulfide detector vs. gas chromatography. Journal of Dental Research, 81, 140-143. doi:10.1177/154405910208100211
[22] Nalcaci, R. and Baran, I. (2008) Oral malodor and removable complete dentures in the elderly. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 105, e5-e9. doi:10.1016/j.tripleo.2008.02.016
[23] Yaegaki, K. and Sanada, K. (1992) Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. Journal of Periodontal Research, 27, 233-238. doi:10.1111/j.1600-0765.1992.tb01673.x
[24] DeBoever, E.H. and Loesche, W.J. (1995) Assessing the contribution of anaerobic microflora of the tongue to oral malodor. Journal of the American Dental Association, 126, 1384-1393.
[25] Seemann, R. (2006) Tongue scrapers may reduce halitosis in adults. Evidence-Based Dentistry, 7, 78. doi:10.1038/sj.ebd.6400433
[26] Haraszthy, V.I., Gerber, D., Clark, B., Moses, P., Parker, C., Sreenivasan, P.K. and Zambon, J.J. (2008) Characterization and prevalence of Solobacteriummoorei associated with oral halitosis. Journal of Breath Research, 2, Article ID: 017002. doi:10.1088/1752-7155/2/1/017002

  
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