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Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report

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DOI: 10.4236/ijcm.2012.36092    4,679 Downloads   6,767 Views  

ABSTRACT

Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

H. Binnenmars, H. Idzerda, H. Tan and G. Linssen, "Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report," International Journal of Clinical Medicine, Vol. 3 No. 6, 2012, pp. 513-517. doi: 10.4236/ijcm.2012.36092.

References

[1] S. Nishino, “Narcolepsy: Pathophysiology and Pharmacology,” Journal of Clinical Psychiatry, Vol. 68, Suppl. 13, 2007, pp. 9-15.
[2] I. Morrison and R. L. Riha, “Excessive Daytime Sleepiness and Narcolepsy—An Approach to Investigation and Management,” European Journal of Internal Medicine, Vol. 23, No. 2, 2012, pp. 110-117. doi:10.1016/j.ejim.2011.09.005
[3] B. K. Madras, Z. Xie, Z. Lin, A. Jassen, H. Panas, L. Lynch, R. Johnson, E. Livni, T. J. Spencer, A. A. Bonab, G. M. Miller and A. J. Fischman, “Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro,” Journal of Pharmacology and Experimental Therapeutics, Vol. 319, No. 2, 2006, pp. 561-569. doi:10.1124/jpet.106.106583
[4] M. J. Minzenberg and C. S. Carter, “Modafinil: A Review of Neurochemical Actions and Effects on Cognition,” Neuropsychopharmacology, Vol. 33, No. 7, 2008, pp. 1477-1502. doi:10.1038/sj.npp.1301534
[5] R. Kumar, “Approved and Investigational Uses of Modafinil: An Evidence-Based Review,” Drugs, Vol. 68, No. 13, 2008, pp. 1803-1839. doi:10.2165/00003495-200868130-00003
[6] W. M. Qu, Z. L. Huang, X. H. Xu, N. Matsumoto and Y. Urade, “Dopaminergic D1 and D2 Receptors Are Essential for the Arousal Effect of Modafinil,” Journal of Neuroscience, Vol. 28, No. 34, 2008, pp. 8462-8469. doi:10.1523/JNEUROSCI.1819-08.2008
[7] N. Oskooilar, “A Case of Premature Ventricular Contractions with Modafinil,” American Journal of Psychiatry, Vol. 162, No. 10, 2005, pp. 1983-1984. doi:10.1176/appi.ajp.162.10.1983-a

  
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