Overview of Multidrug-Resistant Pseudomonas aeruginosa and Novel Therapeutic Approaches

Marilyn Porras-Gómez, José Vega-Baudrit, Santiago Núñez-Corrales

e-Science Research Program, Instituto Tecnológico de Costa Rica TEC, Cartago, Costa Rica.
Laboratorio Nacional de Nanotecnología LANOTEC, Centro Nacional de Alta Tecnología CeNAT, San José, Costa Rica.

DOI: 10.4236/jbnb.2012.324053                

Abstract

Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized patients, contributing to their morbidity and mortality due to its multiple resistance mechanisms. Therefore, as therapeutic options become restricted, the search for new agents is a priority. Latterly an accelerated increase in frequency of multidrug-resistant clinical strains has severely limited the availability of therapeutic options. Several in vitro and in vitro studies evaluating the efficacy of different antimicrobials agents and development of vaccines against P. aeruginosa have been reported as novel approaches, such as inhibition of virulence factor expression or inhibition of their metabolic pathways.

Keywords

Bacilli; Gram-Negative; Pseudomonas aeruginosa; Multidrug Resistance; Pathogen; Resistance Mechanisms

Conflicts of Interest

The authors declare no conflicts of interest.

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