Mechanisms of C-reactive protein, interleukin-6 and soluble CD40L blood concentration changes after coronary stent implantation

Alvaro Merino, Javier Calvo, Antoni Gayá, Ignacio Segura, Cristina Imízcoz

Fundació Banc de Sang i Teixits de Les Illes Balears, Palma de Mallorca, Spain.
Institut Cardiologic, Clínica Rotger, Palma de Mallorca, Spain.
nstitut Cardiologic, Clínica Rotger, Palma de Mallorca, Spain.

DOI: 10.4236/wjcd.2012.24038                

Abstract

Background: The pathway linking inflammation and thrombosis has been extensively studied. Experimental data support that arterial thrombosis also induces a detectable inflammatory response, which in turn, activates prothrombotic pathways closing a vicious circle that interconnects inflammation and thrombosis. Aim: We designed this study to investigate the causes of inflammatory markers increase after coronary angioplasty. Methods: We analyzed the interrelationship of thrombotic and inflammatory markers and the effect of blocking thrombus formation on the inflammatory response in 50 patients undergoing high thrombotic risk coronary angioplasty. The relationship of platelet number to soluble CD40 Ligand, Interleukin-6 and C-reactive protein blood levels was studied. Half of the study population was treated with standard antithrombotic drugs and the other half with the standard therapy plus platelet GP IIb-IIIa receptor inhibitor Eptifibatide. Results: There was a clear correlation between basal platelet count and sCD40L basal levels, post-angioplasty sCD40L increase and post-angioplasty IL-6 levels and post-angioplasty IL-6 levels with post-angioplasty CRP levels. Postangioplasty CRP, IL-6 and sCD40L blood levels were influenced by GP IIb-IIIa treatment in patients with angiographic thrombus. Conclusion: Platelet aggregation induces a proinflammatory response which is blocked by a GP IIb-IIIa inhibitor agent, particularly in patients with patent angiographic thrombus.

Keywords

Angioplasty; Inflammation; C-Reactive Protein; Interleukin-6; CD40 Ligand

Conflicts of Interest

The authors declare no conflicts of interest.

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