Share This Article:

Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma

Abstract Full-Text HTML Download Download as PDF (Size:137KB) PP. 589-594
DOI: 10.4236/jct.2012.35075    3,651 Downloads   5,755 Views  

ABSTRACT

Lactic acidosis is a rare complication of malignancies and is seen more frequently in high grade lymphoma and leukemia. Although, its pathogenesis is not well understood, it remains a surrogate of poor prognosis. Herein, we present a case of Burkitt-like lymphoma presenting with metabolic abnormalities including lactic acidosis and hypoglycemia along with atrial tachycardia. We will discuss the different mechanisms involved in these metabolic disturbances and we will provide insight on novel therapeutic strategies based on our understanding of the underlying pathophysiology.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

H. El-Osta, A. Abdulbaki, P. Peddi, A. Takalkar, J. Cotelingam, D. Veillon, A. Vargas, N. Akkus and G. C. Hildebrandt, "Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma," Journal of Cancer Therapy, Vol. 3 No. 5, 2012, pp. 589-594. doi: 10.4236/jct.2012.35075.

References

[1] E. M. Sillos, J. L. Shenep, G. A. Burghen, C. H. Pui, F. G. Behm and J. T. Sandlund, “Lactic Acidosis: A Metabolic Complication of Hematologic Malignancies: Case Report and Review of the Literature,” Cancer, Vol. 92, No. 9, 2001, pp. 2237-2246.doi:10.1002/1097-0142(20011101)92:9<2237::AID-CNCR1569>3.0.CO;2-9
[2] J. Block, W. Bronson and W. Bell, “Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant Effusion,” Annals of Internal Medicine, Vol. 65, No. 1, 1966, pp. 101-108.
[3] S. Sebastian and U. W. Kenkare, “Insulin-Like Growth Factor 1 Induces Tumor Hexokinase RNA Expression in Cancer Cell,” Biochemical and Biophysical Research Communications, Vol. 235, No. 2, 1997, pp. 389-393.doi:10.1006/bbrc.1997.6797
[4] S. P. Mathupala, A. Rempel, P. L. Pedersen, “Aberrant Glycolytic Metabolism of Cancer Cells: A Remarkable Coordination of Genetic, Transcriptional, Post-Translational, and Mutational Events that Lead to a Critical Role for Type II Hexokinase,” Journal of Bioenergetics and Biomembranes, Vol. 29, No. 4, 1997, pp. 339-343. doi:10.1023/A:1022494613613
[5] J. P. Ruiz, A. K. Singh and P. Hart, “Type B Lactic Acidosis Secondary to Malignancy: Case Report, Review of Published Cases, Insights into Pathogenesis, and Prospects for Therapy,” The Scientific World Journal, Vol. 11, 2011, pp. 1316-1324.doi:10.1100/tsw.2011.125
[6] S. Sariban-Sohraby, I. T. Magrath and R. S. Balaban, “Comparison of Energy Metabolism in Human Normal and Neoplastic (Burkitt’s Lymphoma) Lymphoid Cells,” Cancer Research, Vol. 43, No. 10, 1983, pp. 4662-4664.
[7] R. G. Narins, G. G. Krishna, J. Yee, et al., “The Metabolic Acidosis,” In: R. G. Narins, Ed., Maxwell & Kleeman’s Clinical Disorders of Fluid and Electrolyte Metabolism, 5th Edition, McGraw-Hill, Inc., New York, 1994. pp 769-825
[8] J. Svahn, M. Schiaffino, U. Caruso, M. Calvillo, G. Min- niti and C. Dufour, “Type B Lactic Acidosis Secondary to Malignancy: Case Report, Review of Published Cases, Insights into Pathogenesis, and Prospects for Therapy,” Journal of Pediatric Hematology/Oncology, Vol. 25, 2003, pp. 965-968.doi:10.1097/00043426-200312000-00012
[9] S. Osorio, C. Bernis and R. de La Camara, “Lactic Acidosis in Non-Hodgkin’s Lymphoma and Response to Chemotherapy,” Haematologica, Vol. 87, No. 2, 2002, p. 5
[10] A. S. Friedenberg, D. E. Brandoff and F. J. Schiffman, “Type B Lactic Acidosis as a Severe Metabolic Complication in Lymphoma and Leukemia: A Case Series from a Single Institution and Literature Review,” Medicine (Baltimore), Vol. 86, No. 4, 2007, pp. 225-232. doi:10.1097/MD.0b013e318125759a
[11] J. Durig, W. Fiedler, M. de Wit, M. Steffen and D. Hossfeld, “Lactic Acidosis and Hypoglycemia in a Patient with High-Grade Non-Hodgkin’s Lymphoma and Elevated Circulating TNF-a,” Annals of Hematology, Vol. 72, No. 2, 1996, pp. 97-99. doi:10.1007/BF00641317
[12] H. Werner and D. LeRoith, “The Role of the Insulin-Like Growth Factor System in Human Cancer,” Advances in Cancer Research, Vol. 68, 1996, pp. 183-223. doi:10.1016/S0065-230X(08)60354-1
[13] T. A. Yap, D. Olmos, L. R. Molife and J. S. de Bono, “Targeting the Insulin-Like Growth Factor Signaling Pathway: Figitumumab and Other Novel Anticancer Strategies,” Expert Opinion Investigatinal Drugs, Vol. 20, No. 9, 2011, pp. 1293-1304. doi:10.1517/13543784.2011.602630
[14] J. J. Glasheen and M. D. Sorensen, “Burkitt’s Lymphoma Presenting with Lactic Acidosis and Hypoglycemia—A Case Presentation,” Leukemia & Lymphoma, Vol. 46, No. 2, 2005, pp. 281-283. doi:10.1080/10428190400016723
[15] M. López Rodríguez, E. Vázquez Munoz, J. Gómez Cerezo, B. Pagán Munoz, E. Ruiz Bravo-Burguillos, F. J. Barbado Hernández, “Lactic Acidosis, Severe Hypoglycemia and Hepatosplenomegaly,” Revista Clínica Espanola, Vol. 207, No. 10, 2007, pp. 521-522. doi:10.1157/13111552
[16] T. Révész, K. Obeid and C. Mpofu, “Severe Lactic Acidosis and Renal Involvement in a Patient with Relapsed Burkitt’s Lymphoma,” Journal of Pediatric Hematology/Oncology, Vol. 12, No. 3, 1995, pp. 283-288. doi:10.3109/08880019509029570
[17] C. Bergin, R. Pilkington, C. McCreary, F. Mulcahy and V. Crowley, “Lactic Acidosis, Non-Hodgkins Lymphoma and the Acquired Immunodeficiency Syndrome,” Genitourinary Medicine, Vol. 70, No. 2, 1994, pp. 148-149. doi:10.1136/sti.70.2.148
[18] B. Mégarbane, F. Bruneel, V. Andrieu, M. Wolff and B. Régnier, “The Last Voyage of a Globe-Trotter,” La Revue de Médecine Interne, Vol. 21, Suppl. 3, 2000, pp. 340s-342s. doi:10.1016/S0248-8663(00)89263-2
[19] P. Rouzet, H. Rubie, A. Robert, A. Dutour, J. P. Olives, C. Scipioni, J. Guitard and C. Régnier, “Severe Hyperlactacidemia in 2 Children Treated for Malignant Tumors. Role of Vitamin B1,” Archives Francaises de Pédiatrie, Vol. 48, No. 6, 1991, pp. 423-426.
[20] K. Kulkarni, S. Kaur, A. Sibal, N. Jerath and L. S. Arya, “Severe Lactic Acidosis, Hypertriglyceridemia, and Extensive Axial Skeleton Involvement in a Case of Disseminated Burkitt’s Lymphoma,” International Journal of Hematology, Vol. 91, No. 3, 2010, pp. 546-548.doi:10.1007/s12185-010-0534-8
[21] M. V. Rastogi, N. Desai and J. B. Quintos, “Non-Islet-Cell Tumor Hypoglycemia and Lactic Acidosis in a Child with Congenital HIV and Burkitt’s Lymphoma,” Journal of Pediatric Endocrinology & Metabolism, Vol. 21, No. 8, 2008, pp. 805-810. doi:10.1515/JPEM.2008.21.8.805
[22] D. Karantanis, J. M. Durski, V. J. Lowe, M. A. Nathan, B. P. Mullan, E. Georgiou, P. B. Johnston and G. A. Wiseman, “18F-FDG PET and PET/CT in Burkitt’s Lymphoma,” European Journal of Radiology, Vol. 75, No. 1, 2010, pp. e68-e73. doi:10.1016/j.ejrad.2009.07.035
[23] K. K. Poh, R. C. Cury, J. Solis, A. J. Fischman, M. J. Wood, “Images in Cardiovascular Medicine. Complementary Role of Multimodality Imaging in the Evaluation of Intracardiac Lymphoma in an HIV-Infected Man,” Circulation, Vol. 115, No. 12, 2007, pp. e339-e341.doi:10.1161/CIRCULATIONAHA.106.664177
[24] D. Mioulet, L. Braem, P. Heno, P. Paule, J. M. Peloni, D. Bonnet and L. Fourcade, “Cardiac Extension of a Non-Hodgkin Lymphoma Revealed by an Atrial Flutter,” Annales de Cardiologie et d’Angéiologie, Vol. 58, No. 2, 2009, pp. 117-121. doi:10.1016/j.ancard.2008.05.007
[25] E. Abinader and S. Rauchfleisch, “Left Atrial Myoma Presenting with Atrial Tachycardia,” Harefuah, Vol. 105, No. 9, 1983, pp. 263-264.
[26] M. Linhart, L. Lickfett, C. Hammerstingl, K. Tiemann, G. Nickenig and T.Lewalter, “Paroxysmal Atrial Flutter Caused by Cardiac Lymphoma,” Pacing and Clinical Electrophysiology, Vol. 29, No. 6, 2006, pp. 682-684.doi:10.1111/j.1540-8159.2006.00419.x
[27] M. A. Thompson, A. Harker-Murray, A. J. Lockets and P. Chareonthaitawee, “Unusual Lymphoma Manifestations: Case 2. Myocardial Lymphoma Presenting as Atrial Flutter,” Journal of Clinical Oncology, Vol. 22, No. 3, 2004, pp. 558-560. doi:10.1200/JCO.2004.12.100
[28] D.Hayes Jr, D. K. M. Liles and V. L. Sorrell, “An Unusual Cause of New-Onset Atrial Flutter: Primary Cardiac Lymphoma,” Southern Medical Journal, Vol. 96, No. 8, 2003, pp. 799-802. doi:10.1097/01.SMJ.0000054225.89526.BD

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.