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Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum

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DOI: 10.4236/health.2012.49106    3,156 Downloads   4,664 Views   Citations


To test if stabilizing Ampicillin trihydrate (AT) with Aluminium-Magnesium Silicate (AMS) can enhance its antibacterial activities, different concentrations of AT solution and of a formulation of AT in the AMS, were made and used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg/Kg (AT), 10 mg/Kg (AT in AMS), 7.5 mg/Kg (AT), 7.5 mg/Kg (AT in AMS). Mean diameter of inhibition zone, 28.39 ± 2.07 mm produced by AT did not vary significantly (P > 0.05) from 26.36 ± 2.05 mm produced by AT in AMS. However, mean Salmonella gallinarum culture forming units per ml of bile, 17.6 ± 11 × 105of the untreated chicks and 3.4 ± 0.81 × 105(80.58% reduction), 2.4 ± 0.67 × 105(85.70% reduction), 5.4 ± 1.93 × 105(69.20% reduction ) and 0.38 ± 0.13 × 105(97.80% reduction ) of the respective treated groups, showed AMS significantly (P < 0.01) improved AT’s ability to clear S. gallinarum infection, in vivo.

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The authors declare no conflicts of interest.

Cite this paper

Ezeibe, M. , Anosa, G. , Okorie, O. , Elendu-Eleke, N. , Okoroafor, O. , Ngene, A. and Chikelu, O. (2012) Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum. Health, 4, 675-678. doi: 10.4236/health.2012.49106.


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