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Melanoma of the vulva: A retrospective study of 46 cases from Queensland

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DOI: 10.4236/ojog.2012.22023    3,560 Downloads   5,804 Views   Citations

ABSTRACT

Objective: To review the records of cases of vulvar melanoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between 1986 and 2009 recognising the high incidence of cutaneous melanoma in Queensland. Methods: Vulvar melanoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: Of the 46 cases 22 died of their disease, nine died of other diseases, ten are still alive and five lost to follow up. The mean age at diagnosis was 65.5 years for nodular melanoma and 69 years for superficial spreading melanoma. All cases were Caucasian. Time from on-set of symptoms to diagnosis averaged 3.2 months. In all 46 cases diagnosis was confirmed histologically. Presenting symptoms included lumps, itch, stinging, bleeding and pain. The most common presenting complaint was a lump. The initial treatment was surgical without a trend to a less radical approach to management. Conclusions: Vulvar melanoma prognosis remains guarded. Increased tumor size, depth of invasion, mitotic rate, groin lymph node positivity and status of disease at the margins of surgical specimens reliably equate to long term outcome. The incidence of vulvar melanoma was not increased in Queensland.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

S. C. Jones, I. , Crandon, A. and Sanday, K. (2012) Melanoma of the vulva: A retrospective study of 46 cases from Queensland. Open Journal of Obstetrics and Gynecology, 2, 120-126. doi: 10.4236/ojog.2012.22023.

References

[1] Incidence of cutaneous melanoma in Queensland 19822007. http://www.cancerqld.org.au/f/QCSOL/View/Incidence_(Diagnosis)/Trends_Over_Time/Melanoma/By_Sex
[2] Coory, M., Baade, P., Aitken, J., Smithers, M., McLeod, G.R.C. and Ring, I. (2006) Trends for in situ and invasive melanoma in Queensland, Australia, 1982-2002. Cancer Causes and Control, 17, 21-27. doi:10.1007/s10552-005-3637-4
[3] Wechter, M.E., Gruber, S.B., Haefner, H.K., Lowe, L., Schwartz, J.L., Reynolds, K.R., Johnston, C.M. and Johnson, T.M. (2004) Vulvar melanoma: A report of 20 cases and a review of the literature. Journal of the American Academy of Dermatology, 50, 554-562. doi:10.1016/j.jaad.2003.07.026
[4] Rollason, T.P. (1992) Malignant melanoma and related lesions of the lower female genital tract. In: Lowe, D. and H., Fox, Eds., Advances in Gynaecological Pathology, Churchill Livingstone, Edinburgh, 119-143.
[5] Curtin, J.P. and Morrow, C.P. (1992) Melanoma of the lower female genital tract. In: Coppleson, M., Ed., Gynecologic Oncology, 2nd Edition, Churchill Livingstone, Edinbrugh, 1059-1068.
[6] Ridley, C.M. (2009) The vulva. Neill, S. and Lewis, F. Eds., 3rd Edition, Wiley-Blackwell, Oxford, 211.
[7] de Hullu, J., Hollema, H., Hoeekstra, H.J., Piers, D.A., Mouritis, M.J.E., Aalders, J.G. and van der Zee, A.G.J. (2002) Vulvar melanoma: Is there a role for sentinel lymph node biopsy? Cancer, 94, 486-491. doi:10.1002/cncr.10230
[8] Verschraegen, C.F., Benjapibal, M., Supakarapongkul, W., Levy, L.B., Ross, M., Atkinson, E.N., Bodurka-Bevers, D., Kavanagh, J.J., Kudelka, A.P. and Legha, S.S. (2001) Vulvar melanoma at the M.D. Anderson cancer center: 25 years later. International Journal of Gynecological Cancer, 11, 359-364. doi:10.1046/j.1525-1438.2001.01043.x
[9] Lloyd, J. and Flanagan, A.M. (2000) Mammary and extramammary Paget’s disease. Journal of Clinical Pathology, 53, 742-749. doi:10.1136/jcp.53.10.742
[10] Balch, C.M., Gershenwald, J.E., Soong, S., et al. (2009) Final version of 2009 AJCC melanoma staging and classification. Journal of Clinical Oncology, 27, 6199-6206. doi:10.1200/JCO.2009.23.4799
[11] Look, K.Y., Roth, L.M. and Sutton, G.P. (1993) Vulvar melanoma reconsidered. Cancer, 72, 143-146. doi:10.1002/1097-0142(19930701)72:1<143::AID-CNCR2820720127>3.0.CO;2-M
[12] Dunton, C.J., Kautzy, M. and Hanau, C. (1995) Maligant melanoma of the vulva: A review. Obstetrics and Gynecology Survey, 50, 739-746.
[13] de Hullu, J., Oonk, M. and van dar Zee, A. (2004) Modern management of vulvar cancer. Current Opinion in Obstetrics & Gynecology, 16, 65-72. doi:10.1097/00001703-200402000-00012
[14] Bouma, J., Weening, J.J. and Elders, A. (1982) Malignant melanoma of the vulva: Report of 18 cases. European Journal of Obstetrics & Gynecology and Reproductive Biology, 13, 237-251. doi:10.1016/0028-2243(82)90105-8
[15] Podratz, K.C., Gaffey, T.A., Symmonds, R.E., et al. (1983) Melanoma of the vulva: An update. Gynecologic Oncology, 16, 153-168. doi:10.1016/0090-8258(83)90090-2
[16] Bradgate, M.J., Rollason, T.P., McConkey, C. and Powell, J. (1990) Malignant melanoma of the vulva: A clinico-pathological study of 30 women. British Journal of Obstetrics and Gynaecology, 97, 124-133. doi:10.1111/j.1471-0528.1990.tb01737.x
[17] Miller, B.J., Rutherford, L.F., McLeod, G.R.C. and Cohen, J.R. (2008) Where the sun never shines: Anorectal melanoma. ANZ Journal of Surgery, 67, 846-848. doi:10.1111/j.1445-2197.1997.tb07609.x

  
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