Biography

Prof. Paul J. Higgins

Albany Medical College, USA

 

Email: HigginP@mail.amc.edu

 

Qualifications

 

1976  Ph.D., New York University, New York, NY

1973  M.S, Long Island University, Brooklyn, NY

1968  B.S., Iona College, New Rochelle, NY

 

Publications (Selected)

  1. Mondal, V., Higgins, P. J., & Samarakoon, R. (2024). Emerging role of Hippo-yap (yes-associated Protein)/TAZ (transcriptional coactivator with PDZ-Binding motif) pathway dysregulation in renal cell carcinoma progression. Cancers, 16(15), 2758.
  2. Czekay, R. P., Higgins, C. E., Aydin, H. B., Samarakoon, R., Subasi, N. B., Higgins, S. P., ... & Higgins, P. J. (2024). SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment. Cells, 13(10), 796.
  3. Mazumder, S., Higgins, P. J., & Samarakoon, R. (2023). Downstream targets of VHL/HIF-α signaling in renal clear cell carcinoma progression: mechanisms and therapeutic relevance. Cancers, 15(4), 1316.
  4. Mende, C. W., Samarakoon, R., & Higgins, P. J. (2023). Mineralocorticoid receptor-associated mechanisms in diabetic kidney disease and clinical significance of mineralocorticoid receptor antagonists. American Journal of Nephrology, 54(1-2), 50-61.
  5. Gifford, C. C., Meyerson, B., Goldschmeding, R., Samarakoon, R., & Higgins, P. J. (2022). Osteopontin Is a Key Orchestrator of Plasminogen Activator Inhibitor-1 (PAI-1) Induced Tubular Pathologies: TH-PO538. Journal of the American Society of Nephrology, 33(11S), 199.
  6. Overstreet, J. M., Gifford, C. C., Tang, J., Higgins, P. J., & Samarakoon, R. (2022). Emerging role of tumor suppressor p53 in acute and chronic kidney diseases. Cellular and Molecular Life Sciences, 79(9), 474.
  7. Heiserman, J. P., Nallanthighal, S., Gifford, C. C., Graham, K., Samarakoon, R., Gao, C., ... & Cheon, D. J. (2021). Heat shock protein 27, a novel downstream target of collagen type XI alpha 1, synergizes with fatty acid oxidation to confer cisplatin resistance in ovarian cancer cells. Cancers, 13(19), 4855.
  8. Donnelly, L., Tang, J., Lian, F., Higgins, P., & Samarakoon, R. (2021). MP29-02 SUSTAINED PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) EXPRESSION DURING OBSTRUCTIVE UROPATHY PROMOTES GLYCOLYTIC REPROGRAMMING AND RENAL FIBROSIS VIA RAC-GTPASE DEPENDENT MECHANISMS. Journal of Urology, 206(Supplement 3), e490.
  9. Higgins, C. E., Tang, J., Higgins, S. P., Gifford, C. C., Mian, B. M., Jones, D. M., ... & Higgins, P. J. (2021). The genomic response to TGF-β1 dictates failed repair and progression of fibrotic disease in the obstructed kidney. Frontiers in cell and developmental biology, 9, 678524.
  10. Gifford, C. C., Lian, F., Tang, J., Costello, A., Goldschmeding, R., Samarakoon, R., & Higgins, P. J. (2021). PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-β1-receptor signaling. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 35(7), e21725.
  11. Gifford, C. C., Tang, J., Costello, A., Khakoo, N. S., Nguyen, T. Q., Goldschmeding, R., ... & Samarakoon, R. (2021). Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities. Clinical science, 135(2), 275-303.
  12. Gifford, C. C., Lian, F., Tang, J., Costello, A., Goldschmeding, R., Samarakoon, R., & Higgins, P. J. (2020). Plasminogen Activator Inhibitor 1 (PAI-1) Induction During Kidney Injury Promotes Epithelial Dysfunction via TGF-β1 Receptor Signaling and Klotho Downregulation: PO2242. Journal of the American Society of Nephrology, 31(10S), 683-684.
  13. Gao, C., Higgins, P. J., & Zhang, W. (2020). AQP2: mutations associated with congenital nephrogenic diabetes insipidus and regulation by post-translational modifications and protein-protein interactions. Cells, 9(10), 2172.
  14. Zhang, L., Chen, L., Gao, C., Chen, E., Lightle, A. R., Foulke, L., ... & Zhang, W. (2020). Loss of histone H3 K79 methyltransferase Dot1l facilitates kidney fibrosis by upregulating endothelin 1 through histone deacetylase 2. Journal of the American Society of Nephrology, 31(2), 337-349.
  15. Samarakoon, R., Higgins, S. P., Higgins, C. E., & Higgins, P. J. (2019). The TGF-β1/p53/PAI-1 signaling axis in vascular senescence: Role of caveolin-1. Biomolecules, 9(8), 341.
  16. Higgins, C. E., Tang, J., Mian, B. M., Higgins, S. P., Gifford, C. C., Conti, D. J., ... & Higgins, P. J. (2019). TGF-β1–p53 cooperativity regulates a profibrotic genomic program in the kidney: Molecular mechanisms and clinical implications. The FASEB Journal, 33(10), 10596.
  17. Patel, S., Tang, J., Overstreet, J. M., Anorga, S., Lian, F., Arnouk, A., ... & Samarakoon, R. (2019). Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways. The FASEB Journal, 33(9), 9797.
  18. Salter, E., Tang, J., Higgins, P., & Samarakoon, R. (2019). MP71-07 HIPPO/YAP PATHWAY IN OBSTRUCTIVE UROPATHY: A NOVEL CONTRIBUTOR AND PROMISING THERAPEUTIC TARGET. Journal of Urology, 201, e1048.
  19. Tang, J., Gifford, C. C., Samarakoon, R., & Higgins, P. J. (2018). Deregulation of negative controls on TGF-β1 signaling in tumor progression. Cancers, 10(6), 159.
  20. Lian, F., Tang, J., Arnouk, A., Samarakoon, R., & Higgins, P. (2018). MP10-02 PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) EXPRESSION PROMOTES FIBROTIC RENAL TUBULAR DYSFUNCTION. The Journal of Urology, 199(4S), e115-e115.
  21. Anorga, S., Overstreet, J. M., Falke, L. L., Tang, J., Goldschmeding, R. G., Higgins, P. J., & Samarakoon, R. (2018). Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype. The FASEB Journal, 32(5), 2644.
  22. Higgins, S. P., Tang, Y., Higgins, C. E., Mian, B., Zhang, W., Czekay, R. P., ... & Higgins, P. J. (2018). TGF-β1/p53 signaling in renal fibrogenesis. Cellular signalling, 43, 1-10.
  23. Arnouk, A., Goldschmeding, R., Higgins, P., & Samarakoon, R. (2017). CONNECTIVE TISSUE GROWTH FACTOR INDUCTION PROMOTES EPITHELIAL MALADAPTIVE REPAIR IN RENAL FIBROSIS: PD12-09. Journal of Urology, 197(4), e268-e269.
  24. Ferreira, R. B., Wang, M., Law, M. E., Davis, B. J., Bartley, A. N., Higgins, P. J., ... & Law, B. K. (2017). Disulfide bond disrupting agents activate the unfolded protein response in EGFR-and HER2-positive breast tumor cells. Oncotarget, 8(17), 28971.
  25. Samarakoon, R., & Higgins, P. J. (2018). The cytoskeletal network regulates expression of the profibrotic genes PAI-1 and CTGF in vascular smooth muscle cells. Advances in Pharmacology, 81, 79-94.


Profile Details

https://scholar.google.com/citations?hl=zh-CN&user=YluIi_YAAAAJ

https://www.researchgate.net/profile/Paul-Higgins

https://www.amc.edu/researcher/paul-j-higgins-phd/

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