TITLE:
Metabolic Syndrome in People with HIV/AIDS
AUTHORS:
Ana Paula Werberich, Juliana Ceren, Jayder Lucas Hotts Romancini, Giuliano Gomes de Assis Pimentel, Miguel Spack Junior, Áurea Regina Telles Pupulin
KEYWORDS:
HIV/AIDS; Metabolic Syndrome; Metabolic Abnormalities; Brazil
JOURNAL NAME:
World Journal of AIDS,
Vol.3 No.4,
December
2,
2013
ABSTRACT:
Background: Highly Active Antiretroviral Therapy
(HAART) has changed the clinical picture of HIV infection by reducing morbidity
and mortality rates in the population. However, alterations in lipid metabolism
leading to hypertriglyceridemia, hypercholesterolemia, insulin resistance,
hyperglycemia and redistribution of body fat, which are risk factors for
cardiovascular diseases, have emerged. Metabolic Syndrome (MS) is a complex
disorder represented by a set of cardiovascular risk factors commonly
associated with central adiposity and insulin resistance. Aim: Current paper evaluates the prevalence of MS in patients with
HIV/AIDS using HAART from a reference Center in southern Brazil. Methods: Samples comprised patients who had the
infection for at least five years and were undergoing antiretroviral therapy.
Metabolic syndrome was identified according to the National Cholesterol
Education Program Expert Panel on Detection, Evaluation, and Treatment of High
Blood Cholesterol in Adults (NCEP-ATPIII). A physical examination was performed by evaluating
percentage of body fat by bio-impedance and measuring blood pressure,
determination of Body Mass Index and Waist-Hip Ratio, glycaemia, total
cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: 184 patients were evaluated.
MS prevalence was 30% (55 patients), with 30 (16.3%) males and 25 (13.7%)
females. Conclusions: Brazil was
among the first country profoundly impacted by the HIV/AIDS epidemic but today,
Brazil has less than 1% adult HIV prevalence, implemented treatment and
prevention programs early in the epidemic. Whereas there is currently a
significant increase in the survival of HIV patients by HAART, the patients
reveal a higher prevalence of Metabolic Syndrome in this specific population
requiring political strategy of care to this population.