[1]
|
Arthritis Foundation (2015) Osteoarthritis.
http://www.arthritis.org/conditions-treatments/disease-center/osteoarthritis/
|
[2]
|
Cross, M., Smith, E., Hoy, D., Nolte, S., Ackerman, I., Fransen, M., Bridgett, L., Williams, S., Guillemin, F., Hill, C.L., Laslett, L.L., Jones, G., Cicuttini, F., Osborne, R., Vos, T., Buchbinder, R., Woolf, A. and March, L. (2015) The Global Burden of Hip and Knee Osteoarthritis: Estimates from the Global Burden of Disease 2010 Study. Annals of the Rheumatic Diseases, 73, 1323-1330.
https://doi.org/10.1136/annrheumdis-2013-204763
|
[3]
|
Caron, J. and Genovese, R. (2003) Principles and Practices of Joint Disease Treatment. In: Diagnosis and Management of Lameness in the Horse. 2nd Edition, WB Saunders Co., Philadelphia, 746-664.
https://doi.org/10.1016/B978-0-7216-8342-3.50092-9
|
[4]
|
Neundorf, R.H., Lowerison, M.B., Cruz, A.M., Thomason, J.J., McEwen, B.J. and Hurtig, M.B. (2010) Determination of the Prevalence and Severity of Metacarpophalangeal Joint Osteoarthritis in Thoroughbred Racehorses via Quantitative Macroscopic Evaluation. American Journal of Veterinary Research, 71, 1284-1293.
https://doi.org/10.2460/ajvr.71.11.1284
|
[5]
|
McIlwraith, C.W., Frisbie, D.D. and Kawcak. (2012) The Horse as a Model of Naturally Occurring Osteoarthritis. Bone & Joint Research, 1, 297-309.
https://doi.org/10.1302/2046-3758.111.2000132
|
[6]
|
Malda, J., Benders, K.E.M., Klein, T.J., de Grauw, J.C., Kik, M.J., Hutmacher, DW., Saris, D.B., van Weeren, P.R. and Dhert, W.J. (2012) Comparative Study of Depth-Dependent Characteristics of Equine and Human Osteochondral Tissue from the Medial and Lateral Femoral Condyle. Osteoarthritis Cartilage, 20, 1147-1151.
https://doi.org/10.1016/j.joca.2012.06.005
|
[7]
|
Svala, E, LÖfgren, M., Sihlbom, C., Rüetschi, U., Lindahl, A., Ekman, S. and SkiÖldebrand, E. (2016) An Inflammatory Equine Model Demonstrates Dynamic Changes of Immune Response and Cartilage Matrix Molecule Degradation in vitro. Connective Tissue Research, 56, 315-325.
https://doi.org/10.3109/03008207.2015.1027340
|
[8]
|
Tung, J.T., Venta, P.J., Eberhart, S.W., Yuzbasiyan-Gurkan, V., Alexander, L., Caron, J. and Palda, J. (2002) Effects of Anti-Arthritis Preparations on Gene Expression and Enzyme Activity of Cyclooxygenase-2 in Cultured Equine Chondrocytes. American Journal of Veterinary Research, 63, 1134-1139.
https://doi.org/10.2460/ajvr.2002.63.1134
|
[9]
|
Heinecke, L.F., Grzanna, M.W., Au, A.Y., Mochal, C.A., Rashmir-Raven, A. and Frondoza, C.G. (2010) Inhibition of Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Chondrocytes by Avocado Soybean Unsaponifiables and Epigallocatechin Gallate. Osteoarthritis Cartilage, 18, 220-227.
https://doi.org/10.1016/j.joca.2009.08.015
|
[10]
|
Ownby, S.L., Fortuno, L.V., Au, A.Y., Grzanna, M.W., Rashmir-Raven, A.M. and Frondoza, C.G. (2014) Expression of Pro-Inflammatory Mediators Is Inhibited by an Avocado/Soybean Unsaponifiables and Epigallocatechin Gallate Combination. Journal of Inflammation (London), 11, 8. https://doi.org/10.1186/1476-9255-11-8
|
[11]
|
Frondoza, C.G., Fortuno, L.V., Grzanna, M.W., Ownby, S.L., Au, A.Y. and Rashmir-Raven, A.M. (2017) α-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures. Cartilage, 1-9.
https://doi.org/10.1177/1947603516686146
|
[12]
|
David, F., Farley, J., Huang, H., Lavoie, J.P, and Laverty, S. (2007) Cytokine and Chemokine Gene Expression of IL-1β Stimulated Equine Articular Chondrocytes. Veterinary Surgery, 36, 221-227. https://doi.org/10.1111/j.1532-950X.2007.00253.x
|
[13]
|
Bertone, A.L., Palmer, J.L. and Jones, J. (2001) Synovial Fluid Cytokines and Eicosanoids as Markers of Joint Disease in Horses. Veterinary Surgery, 30, 528-538.
https://doi.org/10.1053/jvet.2001.28430
|
[14]
|
Attur, M., Al-Mussawir, H.E., Patel, J., Kitay, A., Dave, M., Palmer, G., Pillinger, M.H. and Abramson, S.B. (2008) Prostaglandin E2 Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor. Journal of Immunology, 181, 5082-5088.
|
[15]
|
Goldring, M.B. and Otero, M. (2011) Inflammation in Osteoarthritis. Current Opinion in Rheumatology, 23, 471-478.
https://doi.org/10.1097/BOR.0b013e328349c2b1
|
[16]
|
Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.P. and Fahmi, H. (2011) Role of Pro-Inflammatory Cytokines in the Pathophysiology of Osteoarthritis. Nature Reviews Rheumatology, 7, 33-32. https://doi.org/10.1038/nrrheum.2010.196
|
[17]
|
Yuan, G.H., Masuko-Hongo, K., Sakata, M., Tsuruha, J., Onuma, H., Nakamura, H., Aoki, H., Kato, T. and Nishioka, K. (2001) The Role of C-C Chemokines and Their Receptors in Osteoarthritis. Arthritis & Rheumatology, 44, 1056-1570.
https://doi.org/10.1002/1529-0131(200105)44:5<1056::AID-ANR186>3.0.CO;2-U
|
[18]
|
Borzì, R.M., Mazzetti, I., Cattini, L., Uguccioni, M., Baggiolini, M. and Facchini, A. (2000) Human Chondrocytes Express Functional Chemokine Receptors and Release Matrix-Degrading Enzymes in Response to C-X-C and C-C Chemokines. Arthritis & Rheumatology, 43, 1734-1741.
https://doi.org/10.1002/1529-0131(200008)43:8<1734::AID-ANR9>3.0.CO;2-B
|
[19]
|
Sandell, L.J., Xing, X., Franz, C., Davies, S., Chang, L.W. and Patra, D. (2008) Exuberant Expression of Chemokine Genes by Adult Human Articular Chondrocytes in Response to IL-1β. Osteoarthritis Cartilage, 16, 1560-1571.
https://doi.org/10.1016/j.joca.2008.04.027
|
[20]
|
Eitner, A., Hofmann, G.O. and Schaible, H.G. (2017) Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models. Frontiers in Molecular Neuroscience, 10, 349. https://doi.org/10.3389/fnmol.2017.00349
|
[21]
|
Abbadie, C., Lindia, J.A., Cumiskey, A.M., Peterson, L.B., Mudgett, J.S., Bayne, E.K., DeMartino, J.A., MacIntyre, D.E. and Forrest, M.J. (2003) Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2. Proceedings of the National Academy of Sciences, 100, 7947-7952.
https://doi.org/10.1073/pnas.1331358100
|
[22]
|
White, F.A., Sun, J., Waters, S.M., Ma, C., Ren, D., Ripsch, M., Steflik, J., Cortright, D.N., Lamotte, R.H. and Miller, R.J. (2005) Excitatory Monocyte Chemoattractant Protein-1 Signaling Is Up-Regulated in Sensory Neurons after Chronic Compression of the Dorsal Root Ganglion. Proceedings of the National Academy of Sciences, 102, 14092-14097. https://doi.org/10.1073/pnas.0503496102
|
[23]
|
Jung, H., Toth, P.T., White, F.A. and Miller, R.J. (2008) Monocyte Chemoattractant Protein-1 Functions as a Neuromodulator in the Dorsal Root Ganglia Neurons. Journal of Neurochemistry, 104, 254-263.
|
[24]
|
Lee, A.S., Ellman, M.B., Yan, D., Kroin, J.S., Cole, B.J., van Wijnen, A.J. and Im, H.J. (2013) Current Review of Molecular Mechanisms Regarding Osteoarthritis and Pain. Gene, 527, 440-447. https://doi.org/10.1016/j.gene.2013.05.069
|
[25]
|
Miller, R.E., Miller, R.J. and Malfait, A.M. (2014) Osteoarthritis Joint Pain: The Cytokine Connection. Cytokine, 70, 185-193.
https://doi.org/10.1016/j.cyto.2014.06.019
|
[26]
|
Scanzello, C.R. (2017) Chemokines and Inflammation in Osteoarthritis: Insights from Patients and Animal Models. Journal of Orthopaedic Research, 35, 735-739.
https://doi.org/10.1002/jor.23471
|
[27]
|
Loveless, M.S. and Fry, A.L. (2016) Pharmacologic Therapies in Musculoskeletal Conditions. Medical Clinics of North America, 10, 869-890.
https://doi.org/10.1016/j.mcna.2016.03.015
|
[28]
|
Geusens, P., Emans, P.J., de Jong, J.J. and van den Bergh, J. (2013) NSAIDs and Fracture Healing. Current Opinion in Rheumatology, 25, 524-531.
https://doi.org/10.1097/BOR.0b013e32836200b8
|
[29]
|
Wixted, J.J., Fanning, P.F., Rothkopf, I., Stein, G. and Lian, J. (2010) Arachidonic Acid, Eicosanoids, and Fracture Repair. Journal of Orthopaedic Trauma, 24, 539-542.
|
[30]
|
Kalish, B.T., Kieran, M.W., Puder, M. and Panigrahy, D. (2013) The Growing Role of Eicosanoids in Tissue Regeneration, Repair, and Wound Healing. Prostaglandins & Other Lipid Mediators, 104-105, 130-138.
https://doi.org/10.1016/j.prostaglandins.2013.05.002
|
[31]
|
Henrotin, Y.E., Sanchez, C., Deberg, M.A., Piccardi, N., Guillou, G.B., Msika, P. and Reginster, J.Y. (2003) Avocado/Soybean Unsaponifiables Increase Aggrecan Synthesis and Reduce Catabolic and Proinflammatory Mediator Production by Human Osteoarthritic Chondrocytes. The Journal of Rheumatology, 30, 1825-1834.
|
[32]
|
Au, R.Y., Al-Talib, T.K., Au, A.Y., Phan, P.V. and Frondoza, C.G. (2007) Avocado Soybean Unsaponifiables (ASU) Suppress TNF-α, IL-1ß, COX-2, and i-NOS Gene Expression, and Prostaglandin E2 and Nitric Oxide Production in Articular Chondrocytes and Monocyte/Macrophages. Osteoarthritis Cartilage, 15, 1249-1255.
https://doi.org/10.1016/j.joca.2007.07.009
|
[33]
|
Gabay, O., Gosset, M., Lev, A., Salvat, C., Sanchez, C., Pigenet, A., Sautet, A., Jacques, C. and Berenbaum, F. (2008) Stress-Induced Signaling Pathways in Hyalin Chondrocytes: Inhibition by Avocado-Soybean Unsaponifiables (ASU). Osteoarthritis and Cartilage, 16, 373-384. https://doi.org/10.1016/j.joca.2007.06.016
|
[34]
|
Lippiello, L., Nardo, J.V., Harlan, R. and Chiou, T. (2008) Metabolic Effects of Avocado/Soy Unsaponifiables on Articular Chondrocytes. Evidence-Based Complementary Alternative Medicine, 5, 191-197. https://doi.org/10.1093/ecam/nem132
|
[35]
|
Du Souich, P., Garcia, A.G., Verges, J. and Montell, E. (2009) Immunomodulatory and Anti-Inflammatory Effects of Chondroitin Sulphate. Journal of Cellular and Molecular Medicine, 13, 1451-1463.
https://doi.org/10.1111/j.1582-4934.2009.00826.x
|
[36]
|
Chan, P.S., Caron, J.P. and Orth, M.W. (2005) Effect of Glucosamine and Chondroitin Sulfate on Regulation of Gene Expression of Proteolytic Enzymes and Their Inhibitors in Interleukin-1-Challanged Bovine Articular Cartilage Explants. American Journal of Veterinary Research, 66, 1870-1876.
https://doi.org/10.2460/ajvr.2005.66.1870
|
[37]
|
Grzanna, M.W., Ownby, S.L., Heinecke, L.F., Au, A.Y. and Frondoza, C.G. (2010) Inhibition of Cytokine Expression and Prostaglandin E2 Production in Monocyte/Macrophage-Like Cells by Avocado Soybean Unsaponifiables and Chondroitin Sulfate. Journal of Complementary and Integrative Medicine, 7, Article 10.
https://doi.org/10.2202/1553-3840.1338
|
[38]
|
Frondoza, C.G., Heinecke, L.F., Grzanna, M.W., Au, A.Y. and Ownby, S.L. (2011) Modulation of Cytokine-Induced Prostaglandin E2 Production in Cultures of Articular Chondrocytes Obtained from Carpal Joints of Camels (Camelus dromedarius). American Journal of Veterinary Research, 72, 51-58.
https://doi.org/10.2460/ajvr.72.1.51
|
[39]
|
Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C. and Chiotelli, E. (2011) Nutraceuticals: Do They Represent a New Era in the Management of Osteoarthritis? A Narrative Review from the Lessons Taken with Five Products. Osteoarthritis Cartilage, 19, 1-21. https://doi.org/10.1016/j.joca.2010.10.017
|
[40]
|
Leffler, C.T., Philippi, A.F., Leffler, S.G., Mosure, J.C. and Kim, P.D. (1999) Glucosamine, Chondroitin, and Manganese Ascorbate for Degenerative Joint Disease of the Knee or Low Back: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Military Medicine, 164, 85-91.
|
[41]
|
Das, A. and Hammad, T.A. (2000) Efficacy of a Combination of FCHG49 Glucosamine Hydrochloride, TRH122 Low Molecular Weight Sodium Chondroitin Sulfate and Manganese Ascorbate in the Management of Knee Osteoarthritis. Osteoarthritis Cartilage, 8, 343-350. https://doi.org/10.1053/joca.1999.0308
|
[42]
|
Provenza, J.R., Shinjo, S.K. and Silva, J.M. (2015) Combined Glucosamine and Chondroitin Sulfate, Once or Three Times Daily, Provides Clinically Relevant Analgesia in Knee Osteoarthritis. Clinical Rheumatology, 34, 1455-14620.
https://doi.org/10.1007/s10067-014-2757-1
|
[43]
|
Navarro, S.L., White, E. and Kantor, E.D. (2015) Randomized Trial of Glucosamine and Chondroitin Supplementation on Inflammation and Oxidative Stress Biomarkers and Plasma Proteomics Profiles in Healthy Humans. PLoS ONE, 10, e0117534.
https://doi.org/10.1371/journal.pone.0117534
|
[44]
|
Chen, A.L., Robbins, M.I. and Zhang, Z. (2017) The Effects of FCHG49 Glucosamine-TRH122, Chondroitin Sulfate-NMX1000 Avocado Soybean Unsaponifiables on Symptomatic Chondral Defects in Elite Ski Jumpers. Journal of Preventive Medicine & Public Health, 1, 1017.
|
[45]
|
Hochberg, M.C., Martel-Pelletier, J., Monfort, J., MÖller, I., Castillo, J.R., Arden, N., Berenbaum, F., Blanco, F.J., Conaghan, P.G., Doménech, G., Henrotin, Y., Pap, T., Richette, P., Sawitzke, A., du Souich, P. and Pelletier, J.P. (2016) Combined Chondroitin Sulfate and Glucosamine for Painful Knee Osteoarthritis: A Multicentre, Randomised, Double-Blind, Non-Inferiority Trial versus Celecoxib. Annals of the Rheumatic Diseases, 75, 37-44. https://doi.org/10.1136/annrheumdis-2014-206792
|
[46]
|
Wildi, L.M., Raynauld, J.P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M. and Pelletier, J.P. (2011) Chondroitin Sulphate Reduces Both Cartilage Volume Loss and Bone Marrow Lesions in Knee Osteoarthritis Patients Starting as Early as 6 Months after Initiation of Therapy: A Randomised, Double-Blind, Placebo-Controlled Pilot Study Using MRI. Annals of the Rheumatic Diseases, 70, 982-989. https://doi.org/10.1136/ard.2010.140848
|
[47]
|
Beinke, S. and Ley, S.C. (2004) Functions of NF-kB1 and NF-kB2 in Immune Cell Biology. Biochemical Journal, 382. 393-409. https://doi.org/10.1042/BJ20040544
|
[48]
|
Berenbaum, F. (2004) Signaling Transduction: Target in Osteoarthritis. Current Opinion in Rheumatology, 16, 616-622.
https://doi.org/10.1097/01.bor.0000133663.37352.4a
|
[49]
|
Jomphe, C., Gabriac, M., Hale, T.M., Héroux, L., Trudeau, L.E., Deblois, D., Montell, E., Vergés, J. and du Souich, P. (2008) Chondroitin Sulfate Inhibits the Nuclear Translocation of Nuclear Factor-κB in Interleukin-1β-Stimulated Chondrocytes. Basic & Clinical Pharmacology & Toxicology, 102, 59-65.
|
[50]
|
Largo, R., Alvarez-Soria, M.A., Díez-Ortego, I., Calvo, E., Sánchez-Pernaute, O., Egido, J. and Herrero-Beaumont, G. (2003) Glucosamine Inhibits IL-1β-Induced NFκB Activation in Human Osteoarthritic Chondrocytes. Osteoarthritis Cartilage, 11, 290-298. https://doi.org/10.1016/S1063-4584(03)00028-1
|
[51]
|
Dalirfardouei, R., Karimi, G. and Jamialahmadi, K. (2016) Molecular Mechanisms and Biomedical Applications of Glucosamine as a Potential Multifunctional Therapeutic Agent. Life Sciences, 152, 21-29. https://doi.org/10.1016/j.lfs.2016.03.028
|
[52]
|
Goodrich, L.R. and Nixon, A. (2006) Medical Treatment of Osteoarthritis in the Horse—A Review. The Veterinary Journal, 171, 51-69.
https://doi.org/10.1016/j.tvjl.2004.07.008
|