Ataga, K., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T., Madden, J., Alvarez, O., Gordeuk, V., Gualando, S., Colella, M., Smith, W., Rollins, S., Stocker, J. and Rother, R. (2017) Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease. The New England Journal of Medicine, 376, 429-439.
https://doi.org/10.1056/NEJMoa1611770

has been cited by the following article:

• TITLE: The Anti-Sickling Properties of Medicinal Plants, Insights in Botanical Medicine*

  AUTHORS: Ioannis Krasias

  KEYWORDS: “Anti-Sickling”, “Medicinal Plants”, “Alternative Medicine”, “Haemoglobinopathies”, “Sickle Cell Anaemia*/Disease*”, “Clinical Haematology”, “Aloe Vera Extract”, “Plant* Extract*” and “Sickle*/Cell*”

  JOURNAL NAME: American Journal of Molecular Biology, Vol.11 No.4, October 29, 2021

  ABSTRACT: SCD is one of the most prevailing homogeneous inherited haemoglobinopathies causing a plethora of various clinical complications to the patients. The high mortality and morbidity severely concern the Western community, where numerous clinical trials and research for a cure are in process. In order to alleviate patients from the severe symptoms of the disease, avoiding the side effects, Botanical Medicine exhibits concrete evidence, as a gold candidate, to be the salvation to the problem. The Preferred Reporting Items for Systematic Review (PRISMA) protocol has been used to achieve extensive research on the topic, focusing on the identification and evaluation of the phytochemical properties of common medicinal plants. Meta-analysis has also been implemented on the results of published literature. Forest plots have been plotted, comparing and evaluating the results’ validity and significance. The meta-analysis results have undoubtedly demonstrated the importance and significance of the medicinal plants and their properties against various clinical complications, focusing on the pathogenicity of SCD. Surprisingly, their effectiveness to suppress haemoglobin polymerisation and increase the Fe2+/Fe3+ ratio in patients, enhanced the normal morphological erythrocytes’ appearance by suppressing the sickle shape of drepanocytes. Research made on the epidemiology of SCD associates the disease with the geographical frequency of malaria infection. Based on the natural selection theory of Charles Darwin, nature aids in the population’s survival by the endemicity of various medicinal plants in areas with increased SCD patients. Limitations to the medicinal plants’ consumptions and further therapeutic options have been discussed.