Author(s)

Miyako Mochizuki¹, Emi Hayashi², Atsushi Yoshimura³, Yuko Toyoda³, Lin Mei⁴, Noboru Hasegawa⁵

¹Kyoto Bunkyo Junior College, Kyoto, Japan.
²Department of Health and Nutrition, Gifu Women’s University, Gifu, Japan.
³Material Science and Engineering, Nagoya Institutes of Technology, Nagoya, Japan.
⁴School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
⁵Department of Health and Medical Sciences, Ishikawa Prefectural Nursing University, Ishikawa, Japan.

We studied the effects of exercise on muscle mitochondria, and lipid and glycogen content in non-alcoholic steatohepatitis (NASH) model rats. Male Sprague-Dawley rats were randomly separated into 3 groups: the control group was fed standard chow; the NASH group was fed a methionine-choline-deficient high-fat diet (MCD); the NASH-exercise group was fed the MCD and exercised three times a week. Exercise training consisted of continuous running for thirty minutes at a 13 m/min, 6° slope on a motor-driven rodent treadmill for 6 weeks. Mitochondria content in NASH group decreased in the both fiber types compared with those of the control group. As compared between the NASH and NASH-exercise groups, however, exercise not only promoted significant improvements in liver fibrosis and cirrhosis and triglyceride (TG) content but also increased mitochondria content in type I muscle fiber in particular. These data suggest that exercise improved hepatic steatosis in NASH model rats and can prevent the progression of NASH.

Metabolic Disease, Non-Alcoholic Steatohepatitis, Intramuscular Lipid, Triglyceride, Glycogen, Histopathological, Fiber Types, Aerobic Exercise

Mochizuki, M. , Hayashi, E. , Yoshimura, A. , Toyoda, Y. , Mei, L. and Hasegawa, N. (2015) Effects of Aerobic Exercise on the Intramuscular Lipid and Glycogen Content of Fiber Types in Soleus Muscles of Non-Alcoholic Steatohepatitis Model Rats. Open Journal of Endocrine and Metabolic Diseases, 5, 131-137. doi: 10.4236/ojemd.2015.510017.