Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents - International Journal of Organic Chemistry

IJOC > Vol.12 No.2, June 2022

International Journal of Organic Chemistry

Volume 12, Issue 2 (June 2022)

ISSN Print: 2161-4687 ISSN Online: 2161-4695

Google-based Impact Factor: 1.26 Citations

Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents ()

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Download as PDF (Size: 502KB) PP. 53-63

DOI: 10.4236/ijoc.2022.122005 45 Downloads 201 Views

Author(s)

Greeshma P. Kumpati^1,2, Michael J. Williams¹, Srinidhi Mereddy³, Joseph L. Johnson^2*, Shirisha Jonnalagadda^1,2*

Affiliation(s)

¹Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN, USA.
²Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN, USA.
³Department of Biology, University of Washington, Seattle, WA, USA.

ABSTRACT

Several quinolino-benzoxaborole derivatives have been prepared to start from aminobenzoxaboroles. These derivatives have been evaluated for their anti-cancer activity on human and murine cancer cell lines and based on their relative non-toxicity, these compounds were further evaluated for their antibacterial activity against E. coli, B. subtilis, and M. smegmatis. The synthesized compounds were also evaluated for antifungal activity in C. albicans and C. neoformans.

KEYWORDS

Benzoxaboroles, Aminobenzoxaboroles, Quinolino-Benzoxaboroles, Anti-Microbial Agents

Share and Cite:

P. Kumpati, G. , Williams, M. , Mereddy, S. , Johnson, J. and Jonnalagadda, S. (2022) Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents. International Journal of Organic Chemistry, 12, 53-63. doi: 10.4236/ijoc.2022.122005.

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