Author(s)

Antoine Tshimpi¹, Patrick de Jésus Ngoma-Kisoko^1,2,3, Aurore Beia¹, Tressy Kalenga-Ngomba¹, Jacqueline Nkondi¹, Fabrice Bokabanja¹, Heritier Mawalala¹, Trésor Monsere¹, Pitshou Kengibe¹, Mireille Nganga Nkanga⁴, Benjamin Longo-Mbenza^1,5

¹Department of Internal medicine, Cliniques Universitaires de Kinshasa, University of Kinshasa, Kinshasa, DR Congo.
²Foundation Aurore, Kinshasa, DR Congo.
³University Catholique of Bukavu, Bukavu, DR Congo.
⁴Department of Medical Biologie, Cliniques Universitaires de Kinshasa, University of Kinshasa, Kinshasa, DR Congo.
⁵Lomo University of Research, Kinshasa, DR Congo.

Introduction: Helicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its management poses a problem because of resistance to antibiotics. However, there are codified treatment protocols covering sequential and concomitant quadritherapy with regard to first-line probabilistic treatment. The objective of this study was to assess the therapeutic efficacy of these 2 treatment regimens in the management of Hp infection at Kinshasa. Methods: This was a mixed study, with documentary, descriptive and interventional approaches, carried out between September 1, 2018 and April 30, 2020. Results: Sixty-four patients were collected, including 36 men against 28 women with a sex ratio of 1H:1F; the mean age was 54 ± 16.5 years. There was an over-representation of senior patients (n = 29); an intermediate number of adult patients (n = 22) and a lower number of young patients (n = 13). 34 and 30 were respectively treated according to the concomitant and sequential regimens. Concomitant quadruple therapy offered an eradication rate of 91.2% compared to 56.7% for sequential quadruple therapy; concomitant treatment, advancing age and absence of risky behavior more quickly predicted the occurrence of eradication success. Conclusion: The present study showed superiority of concomitant quadruple therapy over sequential quadruple therapy in first-line treatment. Alcohol with active smoking had a negative influence, while concomitant quadruple therapy, advancement in age had a positive influence on the success of the eradication of Hp infection.

Helicobacter pylori, Concomitant Quadruple Therapy, Sequential Quadruple Therapy, Eradication, Kinshasa

Tshimpi, A. , Ngoma-Kisoko, P. , Beia, A. , Kalenga-Ngomba, T. , Nkondi, J. , Bokabanja, F. , Mawalala, H. , Monsere, T. , Kengibe, P. , Nkanga, M. and Longo-Mbenza, B. (2022) Assessing of the Therapeutic Efficacy of These 2 Treatment Regimens in the Management of Helicobacter pylori Infection at Kinshasa. Open Journal of Gastroenterology, 12, 71-87. doi: 10.4236/ojgas.2022.123008.