The Role of 5-Aminolevulinic Acid (5-ALA) and Sleep - International Journal of Clinical Medicine

IJCM > Vol.4 No.10, October 2013

International Journal of Clinical Medicine

Volume 4, Issue 10 (October 2013)

ISSN Print: 2158-284X ISSN Online: 2158-2882

Google-based Impact Factor: 0.52 Citations h5-index & Ranking

The Role of 5-Aminolevulinic Acid (5-ALA) and Sleep ()

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DOI: 10.4236/ijcm.2013.410A001 4,066 Downloads 6,115 Views Citations

Author(s)

Michael H. Perez, Terry T. Shintani, Beatriz L. Rodriguez, James Davis, Rosanne C. Harrigan

Affiliation(s)

Department of Complementary and Alternative Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, USA.
Department of Complementary and Alternative Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, USA;.
Department of Geriatric Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, USA.

ABSTRACT

Objective: To determine if there is a relationship between the administration of the dietary supplement containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: A double-blind, randomized parallel-group study was conducted. It was a 4-month study of 40 participants between the ages of 40 and 70. Males and females were recruited equally. There were 20 in each group who had existing sleep disorders. The tool used to measure participant sleep improvement included the Pittsburgh Insomnia Rating Scale-20 Question (PIRS-20). Improved sleep is reflected when the total PIRS-20 score is lower. Results: Improvement in sleep in the group taking 50 mg 5-ALA, compared to controls, was significant. The mean change, from baseline through week 6, was －5.67 units less on the sleep scale than the control group with a p value of 0.001. The mean change from week 6 to week 10 when the participant was no longer taking the supplement was 4.55 units higher than the control group with a p value of 0.062, which is of borderline significance. Conclusions: There is a relationship between the administration of dietary supplements containing 5-ALA and sleep. The results of this study suggest that 5-ALA is associated with improved sleep. The mechanism for sleep improvement needs to be explored. Further research is warranted.

KEYWORDS

Insomnia; Heme; Energy; Metabolism; 5-Aminolevulinic Acid; Sleep

Share and Cite:

M. Perez, T. Shintani, B. Rodriguez, J. Davis and R. Harrigan, "The Role of 5-Aminolevulinic Acid (5-ALA) and Sleep," International Journal of Clinical Medicine, Vol. 4 No. 10A, 2013, pp. 1-7. doi: 10.4236/ijcm.2013.410A001.

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