Study of Photoinduced Interaction between Calf Thymus-DNA and
Bovine Serum Albumin Protein with H2Ti3O7 Nanotubes 467
4. Conclusion
Study of photoinduced interaction between HTO and CT
DNA using UV and fluorescence spectroscopic tools
established that the interaction is quite strong which is
also revealed by the high binding constant. The present
work may be helpful in understanding the interaction
between various photosensitizers and DNA. Clinical ap-
plication of the existing photosensitizer is associated with
some problems such as aggregation of photosensitizers in
aqueous medium, decrease in quantum yield due to ag-
gregation, toxicity etc. HTO nano particles can overcome
all the above mentioned problems. This observation can
also be considered with importance to investigate such
interaction between nanotubes and DNA for future ap-
plication in photodynamic therapy. This study of interac-
tion of HTO with physiologically important BSA protein
will provide some necessary information for the design
and application of new drugs. ultrasensitive detection of
proteins, clinical diagnostics etc.
5. Acknowledgements
Financial assistance from UGC-DAE Center for Scien-
tific Research, Kolkata is gratefully acknowledged. The
authors are obliged to Prof. P. Ayyub of Department of
Condensed Matter Physics and Material Sciences, Tata
Institute of Fundamental Research for providing TEM
and SEM facilities.
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